NP_417904.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
Molecular Weight
61,768 Da
NCBI Official Full Name
gamma-glutamyltranspeptidase
NCBI Protein Information
gamma-glutamyltranspeptidase
UniProt Protein Name
Glutathione hydrolase proenzyme
UniProt Synonym Protein Names
Gamma-glutamyltranspeptidase proenzyme
UniProt Synonym Gene Names
NCBI Summary for ggt
Small subunit is residues 26-390; large subunit is residues 391-580. [More information is available at EcoGene: EG10374]. The ggt gene encodes -glutamyltranspeptidase . [More information is available at EcoCyc: EG10374].
UniProt Comments for ggt
Cleaves the gamma-glutamyl bond of periplasmic glutathione (gamma-Glu-Cys-Gly), glutathione conjugates, and other gamma-glutamyl compounds. The metabolism of glutathione releases free glutamate and the dipeptide cysteinyl-glycine, which is hydrolyzed to cysteine and glycine by dipeptidases; it may function in amino acid uptake/salvage, or possibly in peptidoglycan linkage. Catalyzes the hydrolysis and transpeptidation of many gamma-glutamyl compounds (including some D-gamma-glutamyl substrates), with a preference for basic and aromatic amino acids as acceptors (PubMed:2877974). The KM values for gamma-glutamyl acceptors are so high that it has been proposed transpeptidation is not the physiological role in E.coli (PubMed:2877974, PubMed:8104180).
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Products associated with ggt recombinant protein
Pathways associated with ggt recombinant protein
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