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GDNF recombinant protein :: Glial cell line-derived neurotrophic factor protein (GDNF) Recombinant Protein

Scan QR to view Datasheet Catalog #    MBS969406 GDNF recombinant protein
Unit / Price
0.002 mg  /  $115 +1 FREE 8GB USB
0.01 mg  /  $205 +1 FREE 8GB USB
0.1 mg  /  $720 +1 FREE 8GB USB
0.25 mg  /  $1,230 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Glial cell line-derived neurotrophic factor protein (GDNF), Recombinant Protein

★Popular Item★
 Also Known As   

Recombinant Human Glial cell line-derived neurotrophic factor protein (GDNF) (Active)

 Product Synonym Names    hGDNF; ATF
 Product Gene Name   

GDNF recombinant protein

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Sequence Positions    78-211aa, Full Length of Mature Protein
 Sequence    SPDKQMAVLP RRERNRQAAA ANPENSRGKG RRGQRGKNRG CVLTAIHLNV TDLGLGYETK EELIFRYCSG SCDAAETTYD KILKNLSRNR RLVSDKVGQA CCRPIAFDDD LSFLDDNLVY HILRKHSAKR CGCI
 OMIM    L19063,  3D Structure    ModBase 3D Structure for P39905
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 Host    E Coli
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 Purity/Purification    >=97% as determined by SDS-PAGE and HPLC. (lot specific)
 Form/Format    Liquid containing glycerol
 Tag Information    This protein contains an N-terminal tag and may also contain a C-terminal tag. Tag types are determined by various factors including tag-protein stability, please inquire for tag information.
 Sterility    Sterile filter available upon request.
 Endotoxin    Low endotoxin available upon request.
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 Species    Homo sapiens (Human)
 Biological Activity    Fully biologically active when compared to standard. The ED50 as determined by a cell proliferation assay using rat C6 cells is less than 0.1 ng/ml, corresponding to a specific activity of > 5.0 × 107 IU/mg.
 Storage Buffer    0.2 m filtered 1 x PBS, pH 7.4, with 0.05 % Tween-20,lyophilized
 Endotoxin    Less than 1.0 EU/ug as determined by LAL method.
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 Preparation and Storage    Generally, the shelf life of liquid form is 6 months at -20/-80 degree C. The shelf life of lyophilized form is 12 months at -20/-80 degree C.
 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Other Notes    Small volumes of GDNF recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for GDNF recombinant protein

   Neurotrophic factor that enhances survival and morphological differentiation of dopaminergic neurons and increases their high-affinity dopamine uptake. {ECO:0000269|PubMed:8493557}.
 Product Categories/Family for GDNF recombinant protein    Biological Active Protein; Neuroscience ; Growth Factor
NCBI/Uniprot data below describe general gene information for GDNF. It may not necessarily be applicable to this product.
 NCBI GI #    4503975
 NCBI GeneID    2668
 NCBI Accession #    NP_000505.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_000514.3 [Other Products]
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 UniProt Primary Accession #    P39905 [Other Products]
 UniProt Secondary Accession #    O95448; O95449; O95986; Q6FH33; Q96L44; Q9UD32; Q9UD33; Q9UMV2; Q9UP67; Q9UP97; B7WPK7 [Other Products]
 UniProt Related Accession #    P39905; AAB33493; AAB33494 [Other Products]
 Molecular Weight    30.1 kDa
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 NCBI Official Full Name    glial cell line-derived neurotrophic factor isoform 1 preproprotein
 NCBI Official Synonym Full Names    glial cell derived neurotrophic factor
 NCBI Official Symbol    GDNF [Similar Products]
 NCBI Official Synonym Symbols   
ATF; ATF1; ATF2; HSCR3; HFB1-GDNF
[Similar Products]
 NCBI Protein Information    glial cell line-derived neurotrophic factor
 UniProt Protein Name    Glial cell line-derived neurotrophic factor
 UniProt Synonym Protein Names   
Astrocyte-derived trophic factor; ATF
 Protein Family    Glial cell line-derived neurotrophic factor
 UniProt Gene Name    GDNF [Similar Products]
 UniProt Synonym Gene Names    hGDNF; ATF [Similar Products]
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 NCBI Summary for GDNF    This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate each subunit of the disulfide-linked homodimer. The recombinant form of this protein, a highly conserved neurotrophic factor, was shown to promote the survival and differentiation of dopaminergic neurons in culture, and was able to prevent apoptosis of motor neurons induced by axotomy. This protein is a ligand for the product of the RET (rearranged during transfection) protooncogene. Mutations in this gene may be associated with Hirschsprung disease and Tourette syndrome. This gene encodes multiple protein isoforms that may undergo similar proteolytic processing. [provided by RefSeq, Aug 2016]
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 UniProt Comments for GDNF    GDNF: Neurotrophic factor that enhances survival and morphological differentiation of dopaminergic neurons and increases their high-affinity dopamine uptake. Defects in GDNF may be a cause of Hirschsprung disease type 3 (HSCR3). In association with mutations of RET gene, defects in GDNF may be involved in Hirschsprung disease. This genetic disorder of neural crest development is characterized by the absence of intramural ganglion cells in the hindgut, often resulting in intestinal obstruction. Defects in GDNF are a cause of congenital central hypoventilation syndrome (CCHS); also known as congenital failure of autonomic control or Ondine curse. CCHS is a rare disorder characterized by abnormal control of respiration in the absence of neuromuscular or lung disease, or an identifiable brain stem lesion. A deficiency in autonomic control of respiration results in inadequate or negligible ventilatory and arousal responses to hypercapnia and hypoxemia. Belongs to the TGF-beta family. GDNF subfamily. 5 isoforms of the human protein are produced by alternative splicing.

Protein type: Secreted; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 5p13.2

Cellular Component: extracellular region

Molecular Function: protein binding; protein homodimerization activity; Ras guanyl-nucleotide exchange factor activity; receptor binding

Biological Process: adult locomotory behavior; axon guidance; enteric nervous system development; MAPKKK cascade; metanephros development; mRNA stabilization; negative regulation of apoptosis; negative regulation of neuron apoptosis; nervous system development; neural crest cell migration; neurite development; peristalsis; positive regulation of cell differentiation; positive regulation of cell proliferation; positive regulation of dopamine secretion; positive regulation of monooxygenase activity; positive regulation of transcription from RNA polymerase II promoter; postganglionic parasympathetic nervous system development; regulation of dopamine uptake; regulation of gene expression; signal transduction; sympathetic nervous system development; ureteric bud branching

Disease: Central Hypoventilation Syndrome, Congenital; Hirschsprung Disease, Susceptibility To, 3; Pheochromocytoma
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 Research Articles on GDNF    1. there is a decrease in epidermal GDNF and GFRalpha-1 protein expression in normal human skin with ageing
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with GDNF recombinant proteinPathways associated with GDNF recombinant protein
 Reference Product  PubMed Publications
 RET recombinant protein  >1014 publications with GDNF and RET
 GFRA1 recombinant protein  >323 publications with GDNF and GFRA1
 SRC recombinant protein  >51 publications with GDNF and SRC
 GRB2 recombinant protein  >13 publications with GDNF and GRB2
 SHC1 recombinant protein  >11 publications with GDNF and SHC1
 CREB1 recombinant protein  >5 publications with GDNF and CREB1
 MAPK8 recombinant protein  >4 publications with GDNF and MAPK8
 DOK6 recombinant protein  >2 publications with GDNF and DOK6
 PXN recombinant protein  >2 publications with GDNF and PXN
 Products by Pathway  Pathway Diagram
 Axon Guidance Pathway antibodies  Axon Guidance Pathway Diagram
 Developmental Biology Pathway antibodies  Developmental Biology Pathway Diagram
 NCAM Signaling For Neurite Out-growth Pathway antibodies  NCAM Signaling For Neurite Out-growth Pathway Diagram
 NCAM1 Interactions Pathway antibodies  NCAM1 Interactions Pathway Diagram
 Signaling Events Regulated By Ret Tyrosine Kinase Pathway antibodies  Signaling Events Regulated By Ret Tyrosine Kinase Pathway Diagram
 Spinal Cord Injury Pathway antibodies  Spinal Cord Injury Pathway Diagram
Diseases associated with GDNF recombinant proteinOrgans/Tissues associated with GDNF recombinant protein
 Disease Name  Pubmed Publications
 Neurodegenerative Diseases Antibodies  >663 publications with GDNF and Neurodegenerative Diseases
 Disease Models, Animal Antibodies  >630 publications with GDNF and Disease Models, Animal
 Movement Disorders Antibodies  >583 publications with GDNF and Movement Disorders
 Parkinsonian Disorders Antibodies  >547 publications with GDNF and Parkinsonian Disorders
 Parkinson Disease Antibodies  >489 publications with GDNF and Parkinson Disease
 Nerve Degeneration Antibodies  >290 publications with GDNF and Nerve Degeneration
 Neurologic Manifestations Antibodies  >214 publications with GDNF and Neurologic Manifestations
 Inflammation Antibodies  >192 publications with GDNF and Inflammation
 Brain Injuries Antibodies  >165 publications with GDNF and Brain Injuries
 Hirschsprung Disease Antibodies  >126 publications with GDNF and Hirschsprung Disease
 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >2164 publications with GDNF and Brain
 Embryonic Tissue Antibodies  >386 publications with GDNF and Embryonic Tissue
 Muscle Antibodies  >297 publications with GDNF and Muscle
 Bone Antibodies  >225 publications with GDNF and Bone
 Skin Antibodies  >78 publications with GDNF and Skin
 Ovary Antibodies  >21 publications with GDNF and Ovary
 Placenta Antibodies  >5 publications with GDNF and Placenta
 Uncharacterized Tissue Antibodies  >2 publications with GDNF and Uncharacterized Tissue
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