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GCGR recombinant protein :: Glucagon receptor (GCGR) Recombinant Protein

Scan QR to view Datasheet Catalog #    MBS966020 GCGR recombinant protein
Unit / Price
0.05 mg (E-Coli)  /  $505 +1 FREE 8GB USB
0.2 mg (E-Coli)  /  $670 +1 FREE 8GB USB
0.05 mg (Yeast)  /  $675 +1 FREE 8GB USB
0.5 mg (E-Coli)  /  $740 +1 FREE 8GB USB
0.05 mg (Baculovirus)  /  $830 +1 FREE 8GB USB
0.2 mg (Yeast)  /  $910 +1 FREE 8GB USB
0.5 mg (Yeast)  /  $1,020 +1 FREE 8GB USB
1 mg (E-Coli)  /  $1,040 +1 FREE 8GB USB
0.1 mg (Baculovirus)  /  $1,040 +1 FREE 8GB USB
0.05 mg (Mammalian-Cell)  /  $1,065 +1 FREE 8GB USB
0.5 mg (Baculovirus)  /  $1,515 +1 FREE 8GB USB
1 mg (Yeast)  /  $1,550 +1 FREE 8GB USB
0.1 mg (Mammalian-Cell)  /  $1,630 +2 FREE 8GB USB
1 mg (Baculovirus)  /  $2,030 +2 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Glucagon receptor (GCGR), Recombinant Protein

 Also Known As   

Recombinant Human Glucagon receptor (GCGR)

 Product Synonym Names    Recombinant Glucagon receptor (GCGR); Glucagon receptor; GL-R
 Product Gene Name   

GCGR recombinant protein

[Similar Products]
 Product Synonym Gene Name    GCGR [Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Sequence Positions    26-136. Partial, provide the complete extracellular domain.
 Sequence    AQVMDFLFEK WKLYGDQCHH NLSLLPPPTE LVCNRTFDKY SCWPDTPANT TANISCPWYL PWHHKVQHRF VFKRCGPDGQ WVRGPRGQPW RDASQCQMDG EEIEVQKEVA K
 Chromosome Location    Chromosome: 17; NC_000017.10 (79762010..79771889). Location: 17q25
 OMIM    138033
 3D Structure    ModBase 3D Structure for P47871
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 Host    E Coli or Yeast or Baculovirus or Mammalian Cell
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 Purity/Purification    >=90% (lot specific)
 Form/Format    Liquid containing glycerol
 Tag Information    This protein contains an N-terminal tag and may also contain a C-terminal Myc-tag. N-terminal host tags may vary (His, His-SUMO, His-B2M, GST). Tag types are determined by various factors including tag-protein stability and, therefore, are subject to change; please inquire for tag information.
 Sterility    Sterile filter available upon request.
 Endotoxin    Low endotoxin available upon request.
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 Species    Homo sapiens (Human)
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 Preparation and Storage    Store at -20 degree C. For extended storage, store at -20 or -80 degree C.
 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Other Notes    Small volumes of GCGR recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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NCBI/Uniprot data below describe general gene information for GCGR. It may not necessarily be applicable to this product.
 NCBI GI #    4503947
 NCBI GeneID    2642
 NCBI Accession #    NP_000151.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_000160.3 [Other Products]
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 UniProt Primary Accession #    P47871 [Other Products]
 UniProt Secondary Accession #    Q2M3M5 [Other Products]
 UniProt Related Accession #    P47871 [Other Products]
 Molecular Weight    54,009 Da [Similar Products]
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 NCBI Official Full Name    glucagon receptor
 NCBI Official Synonym Full Names    glucagon receptor
 NCBI Official Symbol    GCGR [Similar Products]
 NCBI Official Synonym Symbols   
GGR
[Similar Products]
 NCBI Protein Information    glucagon receptor; GL-R
 UniProt Protein Name    Glucagon receptor
 Protein Family    Glucagon receptor
 UniProt Gene Name    GCGR [Similar Products]
 UniProt Synonym Gene Names    GL-R [Similar Products]
 UniProt Entry Name    GLR_HUMAN
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 NCBI Summary for GCGR    The protein encoded by this gene is a glucagon receptor that is important in controlling blood glucose levels. Defects in this gene are a cause of non-insulin-dependent diabetes mellitus (NIDDM).[provided by RefSeq, Jan 2010]
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 UniProt Comments for GCGR    GCGR: This is a receptor for glucagon which plays a central role in regulating the level of blood glucose by controlling the rate of hepatic glucose production and insulin secretion. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase and also a phosphatidylinositol-calcium second messenger system. Belongs to the G-protein coupled receptor 2 family.

Protein type: GPCR, family 2; Receptor, GPCR; Membrane protein, multi-pass; Membrane protein, integral

Chromosomal Location of Human Ortholog: 17q25

Cellular Component: integral to plasma membrane; integral to membrane; plasma membrane; endosome

Molecular Function: guanyl-nucleotide exchange factor activity; peptide hormone binding; glucagon receptor activity

Biological Process: G-protein signaling, coupled to cAMP nucleotide second messenger; response to starvation; generation of precursor metabolites and energy; exocytosis; hormone-mediated signaling; regulation of blood pressure; energy reserve metabolic process; glucose homeostasis; G-protein signaling, adenylate cyclase activating pathway; response to nutrient; positive regulation of GTPase activity

Disease: Diabetes Mellitus, Noninsulin-dependent
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 Research Articles on GCGR    1. in addition to activation of the classic cAMP/protein kinase A (PKA) pathway, activation of GCGR also induced beta-catenin stabilization and activated beta-catenin-mediated transcription
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with GCGR recombinant proteinPathways associated with GCGR recombinant protein
 Reference Product  PubMed Publications
 GCG recombinant protein  >2 publications with GCGR and GCG
 Products by Pathway  Pathway Diagram
 Class B/2 (Secretin Family Receptors) Pathway antibodies  Class B/2 (Secretin Family Receptors) Pathway Diagram
 G Alpha (q) Signalling Events Pathway antibodies  G Alpha (q) Signalling Events Pathway Diagram
 G Alpha (s) Signalling Events Pathway antibodies  G Alpha (s) Signalling Events Pathway Diagram
 GPCR Downstream Signaling Pathway antibodies  GPCR Downstream Signaling Pathway Diagram
 GPCR Ligand Binding Pathway antibodies  GPCR Ligand Binding Pathway Diagram
 GPCRs, Class B Secretin-like Pathway antibodies  GPCRs, Class B Secretin-like Pathway Diagram
 Gastrin-CREB Signalling Pathway Via PKC And MAPK antibodies  Gastrin-CREB Signalling Pathway Via PKC And MAPK Diagram
 Glucagon Signaling In Metabolic Regulation Pathway antibodies  Glucagon Signaling In Metabolic Regulation Pathway Diagram
 Glucagon-type Ligand Receptors Pathway antibodies  Glucagon-type Ligand Receptors Pathway Diagram
 Integration Of Energy Metabolism Pathway antibodies  Integration Of Energy Metabolism Pathway Diagram
Diseases associated with GCGR recombinant proteinOrgans/Tissues associated with GCGR recombinant protein
 Disease Name  Pubmed Publications
 Hyperplasia Antibodies  >12 publications with GCGR and Hyperplasia
 Diabetes Mellitus, Type 2 Antibodies  >8 publications with GCGR and Diabetes Mellitus, Type 2
 Vascular Diseases Antibodies  >5 publications with GCGR and Vascular Diseases
 Fatty Liver Antibodies  >4 publications with GCGR and Fatty Liver
 Hypertension Antibodies  >4 publications with GCGR and Hypertension
 Weight Loss Antibodies  >4 publications with GCGR and Weight Loss
 Liver Diseases Antibodies  >2 publications with GCGR and Liver Diseases
 Retinal Degeneration Antibodies  >2 publications with GCGR and Retinal Degeneration
 Hypertrophy Antibodies  >2 publications with GCGR and Hypertrophy
 Kidney Neoplasms Antibodies  >1 publications with GCGR and Kidney Neoplasms
 Organ/Tissue Name  Pubmed Publications
 Pancreas Antibodies  >16 publications with GCGR and Pancreas
 Liver Antibodies  >16 publications with GCGR and Liver
 Kidney Antibodies  >3 publications with GCGR and Kidney
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