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GCG recombinant protein :: Glucagon Recombinant Protein

Scan QR to view Datasheet Catalog #    MBS142631 GCG recombinant protein
Unit / Price
0.1 mg  /  $140 +1 FREE 8GB USB
0.5 mg  /  $205 +1 FREE 8GB USB
1 mg  /  $305 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Glucagon (GCG), Recombinant Protein

★Popular Item★
 Also Known As   

Recombinant Human Glucagon

 Product Synonym Names    Glucagon Human; Glucagon Human Recombinant; GLP1; GLP2; GRPP; Glucagon
 Product Gene Name   

GCG recombinant protein

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Sequence    The sequence of the first five N-terminal amino acids was determined and was found to be His-Ser-Gl n-Gly-Thr
 OMIM    138030
 3D Structure    ModBase 3D Structure for P01275
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 Purity/Purification    Greater than 98.0% as determined by:
(a) Analysis by RP-HPLC.
(b) Analysis by SDS-PAGE.
 Form/Format    Each mg of recombinant Glucagon was formulated with 100mg of lactose.
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 Source    E Coli
 Physical Appearance    Sterile Filtered White lyophilized (freeze-dried) powder.
 Solubility    It is recommended to reconstitute the lyophilized Glucagon sterile 18M Omega -cm H2O not less than 100 ug/ml, which can then be further diluted to other aqueous solutions.
 Biological Activity    The activity is determind by comparing, under certain conditions, the hyperglycemic effect it produces with that produced by the international standard or by reference preparation calibrated in IU and is found to be 1 IU/mg.
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 Preparation and Storage    Lyophilized Glucagon although stable at room temperature for 3 weeks, should be stored at 4C.For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).
 Other Notes    Small volumes of GCG recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for GCG recombinant protein

   Description: Glucagon Human Recombinant produced in E Coli is a single, non-glycosylated, polypeptide chain containing 29 amino acids and having a molecular mass of 3483 Dalton. The Glucagon is purified by proprietary chromatographic techniques.

Introduction: Glucagon is an important hormone involved in carbohydrate metabolism. The hormone is synthesized and secreted from alpha cells (?-cells) of the islets of Langerhans, which are located in the endocrine portion of the pancreas. Glucagon is released when the glucose level in the blood is low (hypoglycemia), causing the liver to convert stored glycogen into glucose and release it into the bloodstream. The action of glucagon is thus opposite to that of insulin, which instructs the body's cells to take in glucose from the blood in times of satiation.Glucagon is beneficial for the culture of some cell types. It has been used in some biochemical regulation studies of glycogenolysis in hepatocytes. It has been also been found to induce DNA replication in primary cultures of adult rat hepatocytes when used in combinations with EGF and Insulin. Glucagon increases the blood glucose concentration by promoting rapid breakdown of liver glycogen, and also acts to relax smooth muscle such as the gastrointestinal tract.
 Product Categories/Family for GCG recombinant protein    HORMONES; Hormones; Glucagon
NCBI/Uniprot data below describe general gene information for GCG. It may not necessarily be applicable to this product.
 NCBI GI #    4503945
 NCBI GeneID    2641
 NCBI Accession #    NP_002045.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_002054.4 [Other Products]
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 UniProt Primary Accession #    P01275 [Other Products]
 UniProt Secondary Accession #    Q53TP6; A6NN65 [Other Products]
 UniProt Related Accession #    P01275 [Other Products]
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 NCBI Official Full Name    glucagon preproprotein
 NCBI Official Synonym Full Names    glucagon
 NCBI Official Symbol    GCG [Similar Products]
 NCBI Official Synonym Symbols   
GLP1; GLP2; GRPP
[Similar Products]
 NCBI Protein Information    glucagon; glicentin-related polypeptide; glucagon-like peptide 1; glucagon-like peptide 2; preproglucagon
 UniProt Protein Name    Glucagon
 UniProt Synonym Protein Names   
Incretin hormone
 Protein Family    Glucagon
 UniProt Gene Name    GCG [Similar Products]
 UniProt Synonym Gene Names    GRPP; OXM; OXY; GLP-1; GLP-1(7-37); GLP-1(7-36); GLP-2 [Similar Products]
 UniProt Entry Name    GLUC_HUMAN
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 NCBI Summary for GCG    The protein encoded by this gene is actually a preproprotein that is cleaved into four distinct mature peptides. One of these, glucagon, is a pancreatic hormone that counteracts the glucose-lowering action of insulin by stimulating glycogenolysis and gluconeogenesis. Glucagon is a ligand for a specific G-protein linked receptor whose signalling pathway controls cell proliferation. Two of the other peptides are secreted from gut endocrine cells and promote nutrient absorption through distinct mechanisms. Finally, the fourth peptide is similar to glicentin, an active enteroglucagon. [provided by RefSeq, Jul 2008]
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 UniProt Comments for GCG    GCG: Glucagon plays a key role in glucose metabolism and homeostasis. Regulates blood glucose by increasing gluconeogenesis and decreasing glycolysis. A counterregulatory hormone of insulin, raises plasma glucose levels in response to insulin-induced hypoglycemia. Plays an important role in initiating and maintaining hyperglycemic conditions in diabetes. Glucagon release is stimulated by hypoglycemia and inhibited by hyperglycemia, insulin, and somatostatin. GLP-1 and GLP-2 are induced in response to nutrient ingestion. Glucagon is secreted in the A cells of the islets of Langerhans. GLP-1, GLP-2, oxyntomodulin and glicentin are secreted from enteroendocrine cells throughout the gastrointestinal tract. GLP1 and GLP2 are also secreted in selected neurons in the brain. Belongs to the glucagon family.

Protein type: Hormone; Secreted, signal peptide; Secreted

Chromosomal Location of Human Ortholog: 2q36-q37

Cellular Component: extracellular space; endoplasmic reticulum lumen; plasma membrane; extracellular region

Molecular Function: identical protein binding; protein binding; hormone activity; glucagon receptor binding; receptor binding

Biological Process: positive regulation of protein binding; positive regulation of histone H3-K4 methylation; signal transduction; positive regulation of peptidyl-serine phosphorylation; G-protein signaling, coupled to cAMP nucleotide second messenger; response to starvation; G-protein coupled receptor protein signaling pathway; cell proliferation; cellular protein metabolic process; positive regulation of protein kinase activity; positive regulation of cAMP biosynthetic process; energy reserve metabolic process; feeding behavior; regulation of insulin secretion; negative regulation of apoptosis
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 Research Articles on GCG    1. Data suggest that short-term fasting (severe caloric restriction) dramatically down-regulates plasma glucose, insulin, and C-peptide in men with type 2 diabetes; this occurs without a significant change in plasma glucagon.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with GCG recombinant proteinPathways associated with GCG recombinant protein
 Reference Product  PubMed Publications
 INS recombinant protein  >13 publications with GCG and INS
 GLP1R recombinant protein  >7 publications with GCG and GLP1R
 SST recombinant protein  >5 publications with GCG and SST
 GCGR recombinant protein  >5 publications with GCG and GCGR
 GIPR recombinant protein  >2 publications with GCG and GIPR
 SCT recombinant protein  >2 publications with GCG and SCT
 FOXA2 recombinant protein  >2 publications with GCG and FOXA2
 Products by Pathway  Pathway Diagram
 Class B/2 (Secretin Family Receptors) Pathway antibodies  Class B/2 (Secretin Family Receptors) Pathway Diagram
 Defective ACTH Causes Obesity And Pro-opiomelanocortinin Deficiency (POMCD) Pathway antibodies  Defective ACTH Causes Obesity And Pro-opiomelanocortinin Deficiency (POMCD) Pathway Diagram
 Disease Pathway antibodies  Disease Pathway Diagram
 FOXA1 Transcription Factor Network Pathway antibodies  FOXA1 Transcription Factor Network Pathway Diagram
 G Alpha (q) Signalling Events Pathway antibodies  G Alpha (q) Signalling Events Pathway Diagram
 G Alpha (s) Signalling Events Pathway antibodies  G Alpha (s) Signalling Events Pathway Diagram
 GPCR Downstream Signaling Pathway antibodies  GPCR Downstream Signaling Pathway Diagram
 GPCR Ligand Binding Pathway antibodies  GPCR Ligand Binding Pathway Diagram
 Gastrin-CREB Signalling Pathway Via PKC And MAPK antibodies  Gastrin-CREB Signalling Pathway Via PKC And MAPK Diagram
 Glucagon Signaling In Metabolic Regulation Pathway antibodies  Glucagon Signaling In Metabolic Regulation Pathway Diagram
Diseases associated with GCG recombinant proteinOrgans/Tissues associated with GCG recombinant protein
 Disease Name  Pubmed Publications
 Muscular Diseases Antibodies  >72 publications with GCG and Muscular Diseases
 Diabetes Mellitus, Type 2 Antibodies  >25 publications with GCG and Diabetes Mellitus, Type 2
 Obesity Antibodies  >18 publications with GCG and Obesity
 Vascular Diseases Antibodies  >15 publications with GCG and Vascular Diseases
 Insulin Resistance Antibodies  >12 publications with GCG and Insulin Resistance
 Hyperglycemia Antibodies  >11 publications with GCG and Hyperglycemia
 Kidney Diseases Antibodies  >11 publications with GCG and Kidney Diseases
 Hyperinsulinism Antibodies  >9 publications with GCG and Hyperinsulinism
 Inflammation Antibodies  >8 publications with GCG and Inflammation
 Heart Diseases Antibodies  >8 publications with GCG and Heart Diseases
 Organ/Tissue Name  Pubmed Publications
 Pancreas Antibodies  >39 publications with GCG and Pancreas
 Liver Antibodies  >20 publications with GCG and Liver
 Intestine Antibodies  >19 publications with GCG and Intestine
 Connective Tissue Antibodies  >13 publications with GCG and Connective Tissue
 Stomach Antibodies  >7 publications with GCG and Stomach
 Embryonic Tissue Antibodies  >6 publications with GCG and Embryonic Tissue
 Uterus Antibodies  >1 publications with GCG and Uterus
 Uncharacterized Tissue Antibodies  >1 publications with GCG and Uncharacterized Tissue
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