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Gpi recombinant protein :: Glucose-6-phosphate isomerase Recombinant Protein

Scan QR to view Datasheet Catalog #    MBS955811
SDS-Page
Unit / Price
0.01 mg (E-Coli)  /  $110 +1 FREE 8GB USB
0.05 mg (E-Coli)  /  $190 +1 FREE 8GB USB
0.1 mg (E-Coli)  /  $285 +1 FREE 8GB USB
0.2 mg (E-Coli)  /  $460 +1 FREE 8GB USB
0.5 mg (E-Coli)  /  $750 +1 FREE 8GB USB
0.05 mg (Yeast)  /  $1,045 +1 FREE 8GB USB
0.05 mg (Baculovirus)  /  $1,170 +1 FREE 8GB USB
1 mg (E-Coli)  /  $1,180 +1 FREE 8GB USB
0.2 mg (Yeast)  /  $1,415 +1 FREE 8GB USB
0.05 mg (Mammalian-Cell)  /  $1,420 +1 FREE 8GB USB
0.1 mg (Baculovirus)  /  $1,485 +1 FREE 8GB USB
0.5 mg (Yeast)  /  $1,605 +2 FREE 8GB USB
0.5 mg (Baculovirus)  /  $2,130 +2 FREE 8GB USB
0.1 mg (Mammalian-Cell)  /  $2,140 +2 FREE 8GB USB
1 mg (Yeast)  /  $2,440 +3 FREE 8GB USB
1 mg (Baculovirus)  /  $2,795 +3 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Glucose-6-phosphate isomerase (Gpi), Recombinant Protein

★Popular Item★
 Also Known As   

Recombinant Mouse Glucose-6-phosphate isomerase

 Product Synonym Names    Autocrine motility factor; AMF; Neuroleukin; NLK; Phosphoglucose isomerase; PGI; Phosphohexose isomerase; PHI
 Product Gene Name   

Gpi recombinant protein

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Sequence Positions    2-558aa; Full Length
 Sequence    AALTRNPQFQ KLLEWHRANS ANLKLRELFE ADPERFNNFS LNLNTNHGHI LVDYSKNLVN KEVMQMLVEL AKSRGVEAAR DNMFSGSKIN YTENRAVLHV ALRNRSNTPI KVDGKDVMPE VNRVLDKMKS FCQRVRSGDW KGYTGKSITD IINIGIGGSD LGPLMVTEAL KPYSKGGPRV WFVSNIDGTH IAKTLASLSP ETSLFIIASK TFTTQETITN AETAKEWFLE AAKDPSAVAK HFVALSTNTA KVKEFGIDPQ NMFEFWDWVG GRYSLWSAIG LSIALHVGFD HFEQLLSGAH WMDQHFLKTP LEKNAPVLLA LLGIWYINCY GCETHALLPY DQYMHRFAAY FQQGDMESNG KYITKSGARV DHQTGPIVWG EPGTNGQHAF YQLIHQGTKM IPCDFLIPVQ TQHPIRKGLH HKILLANFLA QTEALMKGKL PEEARKELQA AGKSPEDLEK LLPHKVFEGN RPTNSIVFTK LTPFILGALI AMYEHKIFVQ GIMWDINSFD QWGVELGKQL AKKIEPELEG SSAVTSHDSS TNGLISFIKQ QRDTKLE
 3D Structure    ModBase 3D Structure for P06745
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 Host    E Coli or Yeast or Baculovirus or Mammalian Cell
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 Purity/Purification    Greater than 90% as determined by SDS-PAGE. (lot specific)
 Form/Format    Liquid containing glycerol
 Tag Information    This protein contains an N-terminal tag and may also contain a C-terminal tag. Tag types are determined by various factors including tag-protein stability, please inquire for tag information.
 Sterility    Sterile filter available upon request.
 Endotoxin    Low endotoxin available upon request.
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 Preparation and Storage    Store at -20 degree C, for extended storage, conserve at -20 degree C or -80 degree C.
 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Other Notes    Small volumes of Gpi recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for Gpi recombinant protein

   Besides it's role as a glycolytic enzyme, mammalian GPI can function as a tumor-secreted cytokine and an angiogenic factor (AMF) that stimulates endothelial cell motility. GPI is also a neurotrophic factor (Neuroleukin) for spinal and sensory neurons.
 Product Categories/Family for Gpi recombinant protein    Neuroscience
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 SDS-Page of Gpi recombinant protein    Gpi recombinant protein SDS-Page image
(Note: Representative image, actual molecular weight may vary depending on Tag type and expression host)
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NCBI/Uniprot data below describe general gene information for Gpi. It may not necessarily be applicable to this product.
 NCBI GeneID    14751
 NCBI Accession #    NP_032181.2 [Other Products]
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 UniProt Primary Accession #    P06745 [Other Products]
 UniProt Secondary Accession #    O89062; Q3TEE7; Q3TW50; Q3UUX1; Q3UY84; Q3UZJ1; Q5RJI3; Q8C675; Q9JM07 [Other Products]
 UniProt Related Accession #    P06745 [Other Products]
 Molecular Weight    64.6kD
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 NCBI Official Synonym Full Names    glucose phosphate isomerase 1
 NCBI Official Symbol    Gpi1 [Similar Products]
 NCBI Official Synonym Symbols   
MF; NK; Amf; Gpi; Nlk; Org; Pgi; Phi; Gpi-1; Gpi1s; Gpi-1r; Gpi-1s; Gpi-1t; Gpi1-r; Gpi1-s; Gpi1-t; NK/GPI
[Similar Products]
 NCBI Protein Information    glucose-6-phosphate isomerase
 UniProt Protein Name    Glucose-6-phosphate isomerase
 UniProt Synonym Protein Names   
Autocrine motility factor; AMF; Neuroleukin; NLK; Phosphoglucose isomerase; PGI; Phosphohexose isomerase; PHI
 Protein Family    Glucose-6-phosphate isomerase
 UniProt Gene Name    Gpi [Similar Products]
 UniProt Synonym Gene Names    Gpi1; GPI; AMF; NLK; PGI; PHI [Similar Products]
 UniProt Entry Name    G6PI_MOUSE
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 NCBI Summary for Gpi    This gene encodes a member of the glucose phosphate isomerase protein family. The encoded protein has been identified as a moonlighting protein based on its ability to perform mechanistically distinct functions. In the cytoplasm, the gene product functions as a glycolytic enzyme (glucose-6-phosphate isomerase) that interconverts glucose-6-phophsate and fructose-6-phosphate. Extracellularly, the encoded protein (also referred to as neuroleukin) functions as a neurotrophic factor that promotes survival of skeletal motor neurons and sensory neurons, and as a lymphokine that induces immunoglobulin secretion. The encoded protein is also referred to as autocrine motility factor based on an additional function as a tumor-secreted cytokine and angiogenic factor. [provided by RefSeq, Jan 2014]
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 UniProt Comments for Gpi    G6PI: belongs to the GPI family whose members encode multifunctional phosphoglucose isomerase proteins involved in energy pathways. A dimeric enzyme that catalyzes the reversible isomerization of glucose-6-phosphate and fructose-6-phosphate. Functions in different capacities inside and outside the cell. In the cytoplasm, the gene product is involved in glycolysis and gluconeogenesis, while outside the cell it functions as a neurotrophic factor for spinal and sensory neurons. Defects in this gene are the cause of nonspherocytic hemolytic anemia and a severe enzyme deficiency can be associated with hydrops fetalis, immediate neonatal death and neurological impairment.

Protein type: EC 5.3.1.9; Isomerase; Apoptosis; Carbohydrate Metabolism - amino sugar and nucleotide sugar; Carbohydrate Metabolism - glycolysis and gluconeogenesis; Carbohydrate Metabolism - pentose phosphate pathway; Carbohydrate Metabolism - starch and sucrose; Cytokine

Cellular Component: cytoplasm; cytosol; extracellular region; extracellular space; membrane; myelin sheath; neuron projection; nucleoplasm; plasma membrane

Molecular Function: cytokine activity; glucose-6-phosphate isomerase activity; growth factor activity; intramolecular transferase activity; isomerase activity; monosaccharide binding; protein binding; ubiquitin protein ligase binding

Biological Process: aldehyde catabolic process; angiogenesis; carbohydrate metabolic process; erythrocyte homeostasis; gluconeogenesis; glucose 6-phosphate metabolic process; glucose homeostasis; glycolysis; in utero embryonic development; mesoderm formation; methylglyoxal biosynthetic process; negative regulation of caspase activity; negative regulation of neuron apoptosis
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Product References and Citations for Gpi recombinant protein

   Molecular cloning and expression of neuroleukin, a neurotrophic factor for spinal and sensory neurons.Gurney M.E., Heinrich S.P., Lee M.R., Yin H.-S.Science 234:566-574(1986) Lineage-specific biology revealed by a finished genome assembly of the mouse.Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X., Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y., Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S., Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R., Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K., Eichler E.E., Ponting C.P.PLoS Biol. 7:E1000112-E1000112(2009) Lubec G., Klug S., Kang S.U. Mouse glucose-6-phosphate isomerase and neuroleukin have identical 3' sequences.Faik P., Walker J.I.H., Redmill A.A.M., Morgan M.J.Nature 332:455-456(1988) Proteomic identification of proteins conjugated to ISG15 in mouse and human cells.Giannakopoulos N.V., Luo J.K., Papov V., Zou W., Lenschow D.J., Jacobs B.S., Borden E.C., Li J., Virgin H.W., Zhang D.E.Biochem. Biophys. Res. Commun. 336:496-506(2005) SIRT5-mediated lysine desuccinylation impacts diverse metabolic pathways.Park J., Chen Y., Tishkoff D.X., Peng C., Tan M., Dai L., Xie Z., Zhang Y., Zwaans B.M., Skinner M.E., Lombard D.B., Zhao Y.Mol. Cell 50:919-930(2013) The crystal structure of mouse phosphoglucose isomerase at 1.6A resolution and its complex with glucose 6-phosphate reveals the catalytic mechanism of sugar ring opening.Solomons J.T.G., Zimmerly E.M., Burns S., Krishnamurthy N., Swan M.K., Krings S., Muirhead H., Chirgwin J., Davies C.J. Mol. Biol. 342:847-860(2004) Tumor cell autocrine motility factor is the neuroleukin/phosphohexose isomerase polypeptide.Watanabe H., Takehana K., Date M., Shinozaki T., Raz A.Cancer Res. 56:2960-2963(1996) Crystal structures of mouse autocrine motility factor in complex with carbohydrate phosphate inhibitors provide insight into structure-activity relationship of the inhibitors.Tanaka N., Haga A., Naba N., Shiraiwa K., Kusakabe Y., Hashimoto K., Funasaka T., Nagase H., Raz A., Nakamura K.T.J. Mol. Biol. 356:312-324(2006)
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 Research Articles on Gpi    1. PGI is a moonlighting protein that functions as a cytosolic enzyme involved in glycolysis and gluconeogenesis, and as cytokine through binding to its cell surface receptor.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with Gpi recombinant proteinPathways associated with Gpi recombinant protein
 Reference Product  PubMed Publications
 Eno1 recombinant protein  >2 publications with Gpi and Eno1
 Aldoa recombinant protein  >1 publications with Gpi and Aldoa
 Pfkl recombinant protein  >1 publications with Gpi and Pfkl
 Pgk2 recombinant protein  >1 publications with Gpi and Pgk2
 Pgk1 recombinant protein  >1 publications with Gpi and Pgk1
 Tpi1 recombinant protein  >1 publications with Gpi and Tpi1
 Products by Pathway  Pathway Diagram
 Amino Sugar And Nucleotide Sugar Metabolism Pathway antibodies  Amino Sugar And Nucleotide Sugar Metabolism Pathway Diagram
 Amino Sugar And Nucleotide Sugar Metabolism Pathway antibodies  Amino Sugar And Nucleotide Sugar Metabolism Pathway Diagram
 Carbon Metabolism Pathway antibodies  Carbon Metabolism Pathway Diagram
 Carbon Metabolism Pathway antibodies  Carbon Metabolism Pathway Diagram
 GDP-mannose Biosynthesis Pathway antibodies  GDP-mannose Biosynthesis Pathway Diagram
 GDP-mannose Biosynthesis I Pathway antibodies  GDP-mannose Biosynthesis I Pathway Diagram
 Gene Expression Pathway antibodies  Gene Expression Pathway Diagram
 Generic Transcription Pathway antibodies  Generic Transcription Pathway Diagram
 Gluconeogenesis Pathway antibodies  Gluconeogenesis Pathway Diagram
 Glucose Metabolism Pathway antibodies  Glucose Metabolism Pathway Diagram
Diseases associated with Gpi recombinant proteinOrgans/Tissues associated with Gpi recombinant protein
 Disease Name  Pubmed Publications
 Inflammation Antibodies  >3 publications with Gpi and Inflammation
 Carcinoma Antibodies  >1 publications with Gpi and Carcinoma
 Neurodegenerative Diseases Antibodies  >1 publications with Gpi and Neurodegenerative Diseases
 Death Antibodies  >1 publications with Gpi and Death
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >5 publications with Gpi and Blood
 Ovary Antibodies  >2 publications with Gpi and Ovary
 Bone Antibodies  >2 publications with Gpi and Bone
 Testis Antibodies  >2 publications with Gpi and Testis
 Eye Antibodies  >2 publications with Gpi and Eye
 Bone Marrow Antibodies  >2 publications with Gpi and Bone Marrow
 Muscle Antibodies  >1 publications with Gpi and Muscle
 Joint Antibodies  >1 publications with Gpi and Joint
 Liver Antibodies  >1 publications with Gpi and Liver
 Brain Antibodies  >1 publications with Gpi and Brain
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