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GRIN2A recombinant protein :: Glutamate Receptor Recombinant Protein

Scan QR to view Datasheet Catalog #    MBS2028984 (SPECIAL PROMOTION: Get FREE $5 Starbucks gift card (Maximum 5 gift cards/product). Gift card(s) will be included with shipment)
Unit / Price
0.01 mg  /  $140 +1 FREE 8GB USB
0.05 mg  /  $265 +1 FREE 8GB USB
0.1 mg  /  $410 +1 FREE 8GB USB
0.2 mg  /  $505 +1 FREE 8GB USB
0.5 mg  /  $980 +1 FREE 8GB USB
1 mg  /  $1,445 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Glutamate Receptor (GRIN2A), Recombinant Protein

★Popular Item★
 Also Known As   

Recombinant Glutamate Receptor, Ionotropic, N-Methyl-D-Aspartate 2A (GRIN2A)

 Product Gene Name   

GRIN2A recombinant protein

[Similar Products]
 Matching Pairs    Antibody: Glutamate Receptor (MBS2028287)
Antigen: Glutamate Receptor (MBS2028984)
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    138245
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 Host    E.coli
 Species Reactivity    Human
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 Purity/Purification    > 80%
 Form/Format    20mM Tris, 150mM NaCl, pH8.0, containing 1mM EDTA, 1mM DTT, 0.01% SKL, 5% Trehalose and Proclin300
 Concentration    Original Concentration: 200ug/mL (lot specific)
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 Source    Prokaryotic expression
 Residues    Pro31~Ala555
 Tags    N-terminal His Tag
 Subcellular Location    Membrane
 Traits    Freeze-dried powder
 Predicted isoelectric point    5.3
 Predicted Molecular Mass    62.5kDa
 Accurate Molecular Mass    63kDa as determined by SDS-PAGE reducing conditions
 Usage    Reconstitute in 20mM Tris, 150mM NaCl (pH8.0) to a concentration of 0.1-1.0 mg/mL. Do not vortex.
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 Preparation and Storage    Storage: Avoid repeated freeze/thaw cycles.
Store at 2-8C for one month.
Aliquot and store at -80C for 12 months.
Stability Test: The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37C for 48h, and no obvious degradation and precipitation were observed. The loss rate is less than 5% within the expiration date under appropriate storage condition.
 ISO Certification    Manufactured in an ISO 9001:2015 and ISO 13485:2016 Certified Laboratory.
 Supply Chain Verification    Manufactured in a lab with traceable raw materials manufactured on site. Coordinated product portfolio of antibodies, pairs, conjugates, recombinant proteins, and immunoassay materials available. Please inquire.
 Other Notes    Small volumes of GRIN2A recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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 Applications Tested/Suitable for GRIN2A recombinant protein   

Positive Control, Immunogen, SDS-PAGE, WB
(May be suitable for use in other assays to be determined by the end user.)

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 Sequence of GRIN2A recombinant protein    GRIN2A recombinant protein Sequence image
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 SDS-PAGE of GRIN2A recombinant protein    GRIN2A recombinant protein SDS-PAGE image
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NCBI/Uniprot data below describe general gene information for GRIN2A. It may not necessarily be applicable to this product.
 NCBI GI #    4154321
 NCBI GeneID    2897
 NCBI Accession #    AAD04931.1 [Other Products]
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 UniProt Secondary Accession #    Q13001; Q86SU9 [Other Products]
 UniProt Related Accession #    P39086 [Other Products]
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 NCBI Official Full Name    glutamate receptor, partial
 NCBI Official Synonym Full Names    glutamate receptor, ionotropic, kainate 1
 NCBI Official Symbol    GRIK1 [Similar Products]
 NCBI Official Synonym Symbols   
EAA3; EEA3; GLR5; GLUR5; GluK1
[Similar Products]
 NCBI Protein Information    glutamate receptor ionotropic, kainate 1
 UniProt Protein Name    Glutamate receptor ionotropic, kainate 1
 UniProt Synonym Protein Names   
Excitatory amino acid receptor 3; EAA3; Glutamate receptor 5; GluR-5; GluR5
 Protein Family    Glutamate receptor
 UniProt Gene Name    GRIK1 [Similar Products]
 UniProt Synonym Gene Names    GLUR5; GluK1; EAA3; GluR-5; GluR5 [Similar Products]
 UniProt Entry Name    GRIK1_HUMAN
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 NCBI Summary for GRIN2A    Glutamate receptors are the predominant excitatory neurotransmitter receptors in the mammalian brain and are activated in a variety of normal neurophysiologic processes. This gene product belongs to the kainate family of glutamate receptors, which are composed of four subunits and function as ligand-activated ion channels. The subunit encoded by this gene is subject to RNA editing (CAG->CGG; Q->R) within the second transmembrane domain, which is thought to alter the properties of ion flow. Alternative splicing, resulting in transcript variants encoding different isoforms, has been noted for this gene. [provided by RefSeq, Jul 2008]
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 UniProt Comments for GRIN2A    GluR5: Ionotropic glutamate receptor. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. Binding of the excitatory neurotransmitter L- glutamate induces a conformation change, leading to the opening of the cation channel, and thereby converts the chemical signal to an electrical impulse. The receptor then desensitizes rapidly and enters a transient inactive state, characterized by the presence of bound agonist. May be involved in the transmission of light information from the retina to the hypothalamus. Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family. GRIK1 subfamily. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Channel, ligand-gated; Membrane protein, multi-pass; Membrane protein, integral

Chromosomal Location of Human Ortholog: 21q22.11

Cellular Component: presynaptic membrane; postsynaptic membrane; kainate selective glutamate receptor complex; integral to plasma membrane; dendrite; plasma membrane; cell junction

Molecular Function: extracellular-glutamate-gated ion channel activity; kainate selective glutamate receptor activity

Biological Process: nervous system development; synaptic transmission, glutamatergic; regulation of synaptic transmission, glutamatergic; central nervous system development; glutamate signaling pathway; positive regulation of synaptic transmission, GABAergic; negative regulation of synaptic transmission, glutamatergic; synaptic transmission; regulation of inhibitory postsynaptic membrane potential; behavioral response to pain; ionotropic glutamate receptor signaling pathway; transport; adult behavior; regulation of excitatory postsynaptic membrane potential; positive regulation of gamma-aminobutyric acid secretion
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 Research Articles on GRIN2A    1. This found that, among rs2832407*C of GRIK1 homozygotes, topiramate treatment produced the greatest reductions in the expected positive effects of drinking and desire to drink during the treatment period.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with GRIN2A recombinant proteinPathways associated with GRIN2A recombinant protein
 Reference Product  PubMed Publications
 GRIK2 recombinant protein  >8 publications with GRIN2A and GRIK2
 GRIN1 recombinant protein  >3 publications with GRIN2A and GRIN1
 KARS recombinant protein  >1 publications with GRIN2A and KARS
 GRIP1 recombinant protein  >1 publications with GRIN2A and GRIP1
 DLG4 recombinant protein  >1 publications with GRIN2A and DLG4
 Products by Pathway  Pathway Diagram
 Activation Of Ca-permeable Kainate Receptor Pathway antibodies  Activation Of Ca-permeable Kainate Receptor Pathway Diagram
 Activation Of Kainate Receptors Upon Glutamate Binding Pathway antibodies  Activation Of Kainate Receptors Upon Glutamate Binding Pathway Diagram
 Activation Of Na-permeable Kainate Receptors Pathway antibodies  Activation Of Na-permeable Kainate Receptors Pathway Diagram
 Glutamatergic Synapse Pathway antibodies  Glutamatergic Synapse Pathway Diagram
 Glutamatergic Synapse Pathway antibodies  Glutamatergic Synapse Pathway Diagram
 Ionotropic Activity Of Kainate Receptors Pathway antibodies  Ionotropic Activity Of Kainate Receptors Pathway Diagram
 Neuroactive Ligand-receptor Interaction Pathway antibodies  Neuroactive Ligand-receptor Interaction Pathway Diagram
 Neuroactive Ligand-receptor Interaction Pathway antibodies  Neuroactive Ligand-receptor Interaction Pathway Diagram
 Neuronal System Pathway antibodies  Neuronal System Pathway Diagram
 Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell Pathway antibodies  Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell Pathway Diagram
Diseases associated with GRIN2A recombinant proteinOrgans/Tissues associated with GRIN2A recombinant protein
 Disease Name  Pubmed Publications
 Nervous System Diseases Antibodies  >7 publications with GRIN2A and Nervous System Diseases
 Epilepsy Antibodies  >5 publications with GRIN2A and Epilepsy
 Brain Diseases Antibodies  >4 publications with GRIN2A and Brain Diseases
 Learning Disorders Antibodies  >3 publications with GRIN2A and Learning Disorders
 Pain Antibodies  >2 publications with GRIN2A and Pain
 Down Syndrome Antibodies  >2 publications with GRIN2A and Down Syndrome
 Seizures Antibodies  >2 publications with GRIN2A and Seizures
 Anxiety Disorders Antibodies  >1 publications with GRIN2A and Anxiety Disorders
 Memory Disorders Antibodies  >1 publications with GRIN2A and Memory Disorders
 Cognition Disorders Antibodies  >1 publications with GRIN2A and Cognition Disorders
 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >11 publications with GRIN2A and Brain
 Embryonic Tissue Antibodies  >1 publications with GRIN2A and Embryonic Tissue
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