WP_012478961.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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Molecular Weight
100,520 Da
NCBI Official Full Name
[glutamate--ammonia-ligase] adenylyltransferase
UniProt Protein Name
Bifunctional glutamine synthetase adenylyltransferase/adenylyl-removing enzyme
UniProt Synonym Protein Names
Adenylyl transferase
UniProt Synonym Gene Names
UniProt Comments for glnE
Involved in the regulation of glutamine synthetase GlnA, a key enzyme in the process to assimilate ammonia. When cellular nitrogen levels are high, the C-terminal adenylyl transferase (AT) inactivates GlnA by covalent transfer of an adenylyl group from ATP to specific tyrosine residue of GlnA, thus reducing its activity. Conversely, when nitrogen levels are low, the N-terminal adenylyl removase (AR) activates GlnA by removing the adenylyl group by phosphorolysis, increasing its activity. The regulatory region of GlnE binds the signal transduction protein PII (GlnB) which indicates the nitrogen status of the cell.
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Products associated with glnE recombinant protein
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