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GAD1 recombinant protein :: Glutamate decarboxylase 1 (GAD1) Recombinant Protein

Scan QR to view Datasheet Catalog #    MBS1312638
SDS-PAGE
Unit / Price
0.05 mg (E-Coli)  /  $1,015 +1 FREE 8GB USB
0.05 mg (Yeast)  /  $1,075 +1 FREE 8GB USB
0.05 mg (Baculovirus)  /  $1,200 +1 FREE 8GB USB
0.2 mg (E-Coli)  /  $1,370 +1 FREE 8GB USB
0.05 mg (Mammalian-Cell)  /  $1,450 +1 FREE 8GB USB
0.2 mg (Yeast)  /  $1,460 +1 FREE 8GB USB
0.5 mg (E-Coli)  /  $1,515 +1 FREE 8GB USB
0.1 mg (Baculovirus)  /  $1,525 +1 FREE 8GB USB
0.5 mg (Yeast)  /  $1,650 +2 FREE 8GB USB
1 mg (E-Coli)  /  $2,150 +2 FREE 8GB USB
0.5 mg (Baculovirus)  /  $2,180 +2 FREE 8GB USB
0.1 mg (Mammalian-Cell)  /  $2,185 +2 FREE 8GB USB
1 mg (Yeast)  /  $2,495 +3 FREE 8GB USB
1 mg (Baculovirus)  /  $2,860 +3 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Glutamate decarboxylase 1 (GAD1), Recombinant Protein

★Popular Item★
 Also Known As   

Recombinant Human Glutamate decarboxylase 1 (GAD1)

 Product Synonym Names    Glutamate decarboxylase 1; EC=4.1.1.15; 67 kDa glutamic acid decarboxylase; GAD-67; Glutamate decarboxylase 67 kDa isoform
 Product Gene Name   

GAD1 recombinant protein

[Similar Products]
 Product Synonym Gene Name    GAD1; GAD; GAD67 [Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Sequence Positions    1-594aa; full length protein
 Sequence    MASSTPSSSA TSSNAGADPN TTNLRPTTYD TWCGVAHGCT RKLGLKICGF LQRTNSLEEK SRLVSAFKER QSSKNLLSCE NSDRDARFRR TETDFSNLFA RDLLPAKNGE EQTVQFLLEV VDILLNYVRK TFDRSTKVLD FHHPHQLLEG MEGFNLELSD HPESLEQILV DCRDTLKYGV RTGHPRFFNQ LSTGLDIIGL AGEWLTSTAN TNMFTYEIAP VFVLMEQITL KKMREIVGWS SKDGDGIFSP GGAISNMYSI MAARYKYFPE VKTKGMAAVP KLVLFTSEQS HYSIKKAGAA LGFGTDNVIL IKCNERGKII PADFEAKILE AKQKGYVPFY VNATAGTTVY GAFDPIQEIA DICEKYNLWL HVDAAWGGGL LMSRKHRHKL NGIERANSVT WNPHKMMGVL LQCSAILVKE KGILQGCNQM CAGYLFQPDK QYDVSYDTGD KAIQCGRHVD IFKFWLMWKA KGTVGFENQI NKCLELAEYL YAKIKNREEF EMVFNGEPEH TNVCFWYIPQ SLRGVPDSPQ RREKLHKVAP KIKALMMESG TTMVGYQPQG DKANFFRMVI SNPAATQSDI DFLIEEIERL GQDL
 OMIM    605363
 3D Structure    ModBase 3D Structure for Q99259
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 Host    E Coli or Yeast or Baculovirus or Mammalian Cell
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 Purity/Purification    >=90% (lot specific)
 Form/Format    Liquid containing glycerol
 Tag Information    This protein contains an N-terminal tag and may also contain a C-terminal Myc-tag. N-terminal host tags may vary (His, His-SUMO, His-B2M, GST). Tag types are determined by various factors including tag-protein stability and, therefore, are subject to change; please inquire for tag information.
 Sterility    Sterile filter available upon request.
 Endotoxin    Low endotoxin available upon request.
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 Species    Homo sapiens (Human)
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 Preparation and Storage    Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.
 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Other Notes    Small volumes of GAD1 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Product Description specifically for GAD1 recombinant protein

   Catalyzes the production of GABA.
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 SDS-PAGE of GAD1 recombinant protein    GAD1 recombinant protein SDS-PAGE image
(Note: Representative image, actual molecular weight may vary depending on Tag type and expression host)
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NCBI/Uniprot data below describe general gene information for GAD1. It may not necessarily be applicable to this product.
 NCBI GI #    58331246
 NCBI GeneID    2571
 NCBI Accession #    NP_000808.2 [Other Products]
 NCBI GenBank Nucleotide #    NM_000817.2 [Other Products]
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 UniProt Primary Accession #    Q99259 [Other Products]
 UniProt Secondary Accession #    Q49AK1; Q53TQ7; Q9BU91; Q9UHH4 [Other Products]
 UniProt Related Accession #    Q99259 [Other Products]
 Molecular Weight    69kD
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 NCBI Official Full Name    glutamate decarboxylase 1 isoform GAD67
 NCBI Official Synonym Full Names    glutamate decarboxylase 1 (brain, 67kDa)
 NCBI Official Symbol    GAD1 [Similar Products]
 NCBI Official Synonym Symbols   
GAD; SCP; CPSQ1
[Similar Products]
 NCBI Protein Information    glutamate decarboxylase 1; GAD-67; 67 kDa glutamic acid decarboxylase; glutamate decarboxylase 67 kDa isoform
 UniProt Protein Name    Glutamate decarboxylase 1
 UniProt Synonym Protein Names   
67 kDa glutamic acid decarboxylase; GAD-67; Glutamate decarboxylase 67 kDa isoform
 Protein Family    Glutamate decarboxylase
 UniProt Gene Name    GAD1 [Similar Products]
 UniProt Synonym Gene Names    GAD; GAD67; GAD-67 [Similar Products]
 UniProt Entry Name    DCE1_HUMAN
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 NCBI Summary for GAD1    This gene encodes one of several forms of glutamic acid decarboxylase, identified as a major autoantigen in insulin-dependent diabetes. The enzyme encoded is responsible for catalyzing the production of gamma-aminobutyric acid from L-glutamic acid. A pathogenic role for this enzyme has been identified in the human pancreas since it has been identified as an autoantigen and an autoreactive T cell target in insulin-dependent diabetes. This gene may also play a role in the stiff man syndrome. Deficiency in this enzyme has been shown to lead to pyridoxine dependency with seizures. Alternative splicing of this gene results in two products, the predominant 67-kD form and a less-frequent 25-kD form. [provided by RefSeq, Jul 2008]
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 UniProt Comments for GAD1    GAD67: Catalyzes the production of GABA. Homodimer. Isoform 3 is expressed in pancreatic islets, testis, adrenal cortex, and perhaps other endocrine tissues, but not in brain. Belongs to the group II decarboxylase family. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Amino Acid Metabolism - alanine, aspartate and glutamate; Other Amino Acids Metabolism - taurine and hypotaurine; Mitochondrial; Other Amino Acids Metabolism - beta-alanine; Carbohydrate Metabolism - butanoate; Lyase; EC 4.1.1.15

Chromosomal Location of Human Ortholog: 2q31

Cellular Component: plasma membrane; intracellular; vesicle membrane

Molecular Function: protein binding; glutamate binding; glutamate decarboxylase activity; protein heterodimerization activity; protein N-terminus binding; pyridoxal phosphate binding

Biological Process: response to drug; glutamate catabolic process; synaptic transmission; glutamate decarboxylation to succinate; neurotransmitter secretion; gamma-aminobutyric acid biosynthetic process; protein-pyridoxal-5-phosphate linkage; neurotransmitter biosynthetic process

Disease: Cerebral Palsy, Spastic Quadriplegic, 1
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 Research Articles on GAD1    1. A compensatory role was found for the GAD1 gene hypomethylation in panic disorder depending on genetic variation.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with GAD1 recombinant proteinPathways associated with GAD1 recombinant protein
 Reference Product  PubMed Publications
 GAD2 recombinant protein  >40 publications with GAD1 and GAD2
 Products by Pathway  Pathway Diagram
 Alanine And Aspartate Metabolism Pathway antibodies  Alanine And Aspartate Metabolism Pathway Diagram
 Alanine, Aspartate And Glutamate Metabolism Pathway antibodies  Alanine, Aspartate And Glutamate Metabolism Pathway Diagram
 Alanine, Aspartate And Glutamate Metabolism Pathway antibodies  Alanine, Aspartate And Glutamate Metabolism Pathway Diagram
 Biogenic Amine Synthesis Pathway antibodies  Biogenic Amine Synthesis Pathway Diagram
 Butanoate Metabolism Pathway antibodies  Butanoate Metabolism Pathway Diagram
 Butanoate Metabolism Pathway antibodies  Butanoate Metabolism Pathway Diagram
 GABA (gamma-Aminobutyrate) Shunt Pathway antibodies  GABA (gamma-Aminobutyrate) Shunt Pathway Diagram
 GABA (gamma-Aminobutyrate) Shunt Pathway antibodies  GABA (gamma-Aminobutyrate) Shunt Pathway Diagram
 GABA Synthesis Pathway antibodies  GABA Synthesis Pathway Diagram
 GABA Synthesis, Release, Reuptake And Degradation Pathway antibodies  GABA Synthesis, Release, Reuptake And Degradation Pathway Diagram
Diseases associated with GAD1 recombinant proteinOrgans/Tissues associated with GAD1 recombinant protein
 Disease Name  Pubmed Publications
 Mental Disorders Antibodies  >47 publications with GAD1 and Mental Disorders
 Schizophrenia Antibodies  >30 publications with GAD1 and Schizophrenia
 Nervous System Diseases Antibodies  >23 publications with GAD1 and Nervous System Diseases
 Brain Diseases Antibodies  >18 publications with GAD1 and Brain Diseases
 Disease Models, Animal Antibodies  >11 publications with GAD1 and Disease Models, Animal
 Seizures Antibodies  >9 publications with GAD1 and Seizures
 Autistic Disorder Antibodies  >5 publications with GAD1 and Autistic Disorder
 Anxiety Disorders Antibodies  >5 publications with GAD1 and Anxiety Disorders
 Depressive Disorder Antibodies  >5 publications with GAD1 and Depressive Disorder
 Cognition Disorders Antibodies  >4 publications with GAD1 and Cognition Disorders
 Organ/Tissue Name  Pubmed Publications
 Muscle Antibodies  >2 publications with GAD1 and Muscle
 Kidney Antibodies  >2 publications with GAD1 and Kidney
 Bone Antibodies  >1 publications with GAD1 and Bone
 Embryonic Tissue Antibodies  >1 publications with GAD1 and Embryonic Tissue
 Intestine Antibodies  >1 publications with GAD1 and Intestine
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