Antibody Protein ELISA Kit from MyBioSource header Telephone 1.858.633.0165          
1.855.MyBioSource
Fax 1.858.633.0166    Email sales@mybiosource.com 
tel/fax
menu1 Home Products Ordering Company Help menu7
bottom
   MyBioSource rightarrow Recombinant Protein rightarrow GRIA2  rightarrow LOG IN  rightarrow MY ACCOUNT  rightarrow CART CONTENTS  rightarrow CHECKOUT 
horiz bar
MyBioSource Menu separator
separator
ELISA Kit ELISA Kit
CLIA Kit CLIA Kit
PCR Kit PCR Kit
Monoclonal Antibody Monoclonal Antibody
Polyclonal Antibody Polyclonal Antibody
Secondary Antibody Secondary Antibody
Antigen Antigen
Biochemical Biochemical
cDNA Clone cDNA Clone
siRNA siRNA
Peptide Peptide
Recombinant/Purified Protein Rec./Purified Protein

Custom ELISA Kit Custom ELISA Kit
Custom Protein Custom Protein
Custom Antibody Custom Antibody
Antibody Matched Pairs Antibody Matched Pairs
Antibody & Corresponding Blocking Peptide Pairs Antibody Peptide Pairs
Phospho-Specific Antibodies Phospho Antibodies
Products by Disease Products by Disease
Products by Pathway Products by Pathway
Products by Tissue Products by Tissue

arrow Advanced Search
arrow Submit Technical Q&A
arrow International Distributors
arrow Contact Us
separator
Our Best Sellers moreseparator
separator
 • beta-Human Chorionic Gonadotrophin Protein
 • Haptoglobin (HP) ELISA Kit
 • Resolvin E1 (RvE1) ELISA Kit
 • coagulation factor V, FV ELISA Kit
 • FAK (Ab-407) Antibody
 • Plasminogen Activator, Tissue (tPA) ELISA Kit
 • Lipin 2 (LPIN2) Peptide
 • REST - NRSF Blocking Peptide
 • Set1-Ash2 histone methyltransferase complex subunit ASH2 (AS... Antibody
 • Chemokine (C-X-C motif) ligand 1 (CXCL1) ELISA Kit
 • apolipoprotein E (APOE) ELISA Kit
 • Rab11B Antibody
 • T-cell acute lymphoblastic leukemia antigen (TALLA-1) ELISA Kit
 • PPCS Recombinant Protein
 downarrow more ...
separator
separator
DatasheetFull DatasheetPrinter Friendly DatasheetPrint This DatasheetAdd to Compare ListHave Questions? Ask UsRequest for a Quotation today

GRIA2 recombinant protein :: Glutamate receptor 2 (GRIA2) Recombinant Protein

Scan QR to view Datasheet Catalog #    MBS963411 GRIA2 recombinant protein
Unit / Price
0.05 mg (Baculovirus)  /  $1,765 +2 FREE 8GB USB
0.5 mg (E-Coli)  /  $1,925 +2 FREE 8GB USB
0.5 mg (Yeast)  /  $2,085 +2 FREE 8GB USB
0.1 mg (Baculovirus)  /  $2,200 +2 FREE 8GB USB
1 mg (E-Coli)  /  $2,395 +2 FREE 8GB USB
0.05 mg (Mammalian-Cell)  /  $2,420 +3 FREE 8GB USB
1 mg (Yeast)  /  $2,755 +3 FREE 8GB USB
0.1 mg (Mammalian-Cell)  /  $2,995 +3 FREE 8GB USB
0.5 mg (Baculovirus)  /  $3,480 +4 FREE 8GB USB
1 mg (Baculovirus)  /  $4,350 +5 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Glutamate receptor 2 (GRIA2), Recombinant Protein

★Popular Item★
 Also Known As   

Recombinant Human Glutamate receptor 2 (GRIA2)

 Product Synonym Names    Recombinant Glutamate receptor 2 (GRIA2); Glutamate receptor 2; GluR-2; AMPA-selective glutamate receptor 2 GluR-B GluR-K2 Glutamate receptor ionotropic, AMPA 2; GluA2
 Product Gene Name   

GRIA2 recombinant protein

[Similar Products]
 Product Synonym Gene Name    GRIA2; GLUR2 [Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
Table BarTOPTable Bar
 Sequence Positions    25-543; Fragment at the N-terminal, provide the first complete extracellular domain
 Sequence    NSIQIGGLFP RGADQEYSAF RVGMVQFSTS EFRLTPHIDN LEVANSFAVT NAFCSQFSRG VYAIFGFYDK KSVNTITSFC GTLHVSFITP SFPTDGTHPF VIQMRPDLKG ALLSLIEYYQ WDKFAYLYDS DRGLSTLQAV LDSAAEKKWQ VTAINVGNIN NDKKDEMYRS LFQDLELKKE RRVILDCERD KVNDIVDQVI TIGKHVKGYH YIIANLGFTD GDLLKIQFGG ANVSGFQIVD YDDSLVSKFI ERWSTLEEKE YPGAHTTTIK YTSALTYDAV QVMTEAFRNL RKQRIEISRR GNAGDCLANP AVPWGQGVEI ERALKQVQVE GLSGNIKFDQ NGKRINYTIN IMELKTNGPR KIGYWSEVDK MVVTLTELPS GNDTSGLENK TVVVTTILES PYVMMKKNHE MLEGNERYEG YCVDLAAEIA KHCGFKYKLT IVGDGKYGAR DADTKIWNGM VGELVYGKAD IAIAPLTITL VREEVIDFSK PFMSLGISIM IKKPQKSKPG VFSFLDPLA
 Chromosome Location    Chromosome: 4; NC_000004.11 (158141736..158287227). Location: 4q32.1
 OMIM    138247
 3D Structure    ModBase 3D Structure for P42262
Section Bar
 Host    E Coli or Yeast or Baculovirus or Mammalian Cell
Section Bar
 Purity/Purification    >=90% (lot specific)
 Form/Format    Liquid containing glycerol
 Tag Information    This protein contains an N-terminal tag and may also contain a C-terminal Myc-tag. N-terminal host tags may vary (His, His-SUMO, His-B2M, GST). Tag types are determined by various factors including tag-protein stability and, therefore, are subject to change; please inquire for tag information.
 Sterility    Sterile filter available upon request.
 Endotoxin    Low endotoxin available upon request.
Section Bar
 Species    Homo sapiens (Human)
Section Bar
 Preparation and Storage    Store at -20 degree C. For extended storage, store at -20 or -80 degree C.
 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Other Notes    Small volumes of GRIA2 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Table BarTOPTable Bar
NCBI/Uniprot data below describe general gene information for GRIA2. It may not necessarily be applicable to this product.
 NCBI GI #    74275354
 NCBI GeneID    2891
 NCBI Accession #    NP_000817.2 [Other Products]
 NCBI GenBank Nucleotide #    NM_000826.3 [Other Products]
Section Bar
 UniProt Primary Accession #    P42262 [Other Products]
 UniProt Secondary Accession #    Q96FP6 [Other Products]
 UniProt Related Accession #    P42262 [Other Products]
 Molecular Weight    98,821 Da [Similar Products]
Table BarTOPTable Bar
 NCBI Official Full Name    glutamate receptor 2 isoform 1
 NCBI Official Synonym Full Names    glutamate receptor, ionotropic, AMPA 2
 NCBI Official Symbol    GRIA2 [Similar Products]
 NCBI Official Synonym Symbols   
GLUR2; GLURB; GluA2; HBGR2; GluR-K2
[Similar Products]
 NCBI Protein Information    glutamate receptor 2; gluR-2; gluR-B; AMPA-selective glutamate receptor 2
 UniProt Protein Name    Glutamate receptor 2
 UniProt Synonym Protein Names   
AMPA-selective glutamate receptor 2; GluR-B; GluR-K2; Glutamate receptor ionotropic, AMPA 2
 UniProt Gene Name    GRIA2 [Similar Products]
 UniProt Synonym Gene Names    GLUR2; GluR-2; GluA2 [Similar Products]
 UniProt Entry Name    GRIA2_HUMAN
Section Bar
 NCBI Summary for GRIA2    Glutamate receptors are the predominant excitatory neurotransmitter receptors in the mammalian brain and are activated in a variety of normal neurophysiologic processes. This gene product belongs to a family of glutamate receptors that are sensitive to alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate (AMPA), and function as ligand-activated cation channels. These channels are assembled from 4 related subunits, GRIA1-4. The subunit encoded by this gene (GRIA2) is subject to RNA editing (CAG->CGG; Q->R) within the second transmembrane domain, which is thought to render the channel impermeable to Ca(2+). Human and animal studies suggest that pre-mRNA editing is essential for brain function, and defective GRIA2 RNA editing at the Q/R site may be relevant to amyotrophic lateral sclerosis (ALS) etiology. Alternative splicing, resulting in transcript variants encoding different isoforms, (including the flip and flop isoforms that vary in their signal transduction properties), has been noted for this gene. [provided by RefSeq, Jul 2008]
Section Bar
 UniProt Comments for GRIA2    GluR2: an integral membrane protein belonging to the glutamate-gated ion channel family. L-glutamate (Glu) acts as an excitatory neurotransmitter at many synapses in the central nervous system. Glutamate receptors are heteromeric protein complexes with multiple subunits, each possessing transmembrane regions, and all arranged to form a ligand-gated ion channel. The postsynaptic actions of Glu are mediated by a variety of receptors that are named according to their selective agonists. This receptor binds AMPA(quisqualate) > glutamate > kainate. Each of the four GluR proteins (GRIA1-4) include flip and flop isoforms generated by alternative RNA splicing.

Protein type: Membrane protein, integral; Channel, calcium; Channel, ligand-gated; Membrane protein, multi-pass

Chromosomal Location of Human Ortholog: 4q32.1

Cellular Component: postsynaptic membrane; endoplasmic reticulum membrane; synaptic vesicle; integral to plasma membrane; dendrite; plasma membrane; cell junction

Molecular Function: protein binding; extracellular-glutamate-gated ion channel activity; ionotropic glutamate receptor activity; alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity

Biological Process: synaptic transmission, glutamatergic; synaptic transmission; ionotropic glutamate receptor signaling pathway; signal transduction
Table BarTOPTable Bar
 Research Articles on GRIA2    1. Did not observed significant association between GRIA2 polymorphisms and clinical improvement in patients with Major depressive disorder.But rs4302506 and rs4403097 single nucleotide polymorphisms could be associated with age of onset of the disease.
Table BarTOPTable Bar
 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
Table BarTOPTable Bar
Products associated with GRIA2 recombinant proteinPathways associated with GRIA2 recombinant protein
 Reference Product  PubMed Publications
 GRIA3 recombinant protein  >5 publications with GRIA2 and GRIA3
 NSF recombinant protein  >1 publications with GRIA2 and NSF
 Products by Pathway  Pathway Diagram
 Activation Of AMPA Receptors Pathway antibodies  Activation Of AMPA Receptors Pathway Diagram
 Activation Of NMDA Receptor Upon Glutamate Binding And Postsynaptic Events Pathway antibodies  Activation Of NMDA Receptor Upon Glutamate Binding And Postsynaptic Events Pathway Diagram
 Amphetamine Addiction Pathway antibodies  Amphetamine Addiction Pathway Diagram
 Amphetamine Addiction Pathway antibodies  Amphetamine Addiction Pathway Diagram
 Amyotrophic Lateral Sclerosis (ALS) Pathway antibodies  Amyotrophic Lateral Sclerosis (ALS) Pathway Diagram
 Amyotrophic Lateral Sclerosis (ALS) Pathway antibodies  Amyotrophic Lateral Sclerosis (ALS) Pathway Diagram
 Cocaine Addiction Pathway antibodies  Cocaine Addiction Pathway Diagram
 Cocaine Addiction Pathway antibodies  Cocaine Addiction Pathway Diagram
 Dopaminergic Synapse Pathway antibodies  Dopaminergic Synapse Pathway Diagram
 Dopaminergic Synapse Pathway antibodies  Dopaminergic Synapse Pathway Diagram
Diseases associated with GRIA2 recombinant proteinOrgans/Tissues associated with GRIA2 recombinant protein
 Disease Name  Pubmed Publications
 Mental Disorders Antibodies  >13 publications with GRIA2 and Mental Disorders
 Nervous System Diseases Antibodies  >9 publications with GRIA2 and Nervous System Diseases
 Schizophrenia Antibodies  >8 publications with GRIA2 and Schizophrenia
 Neurobehavioral Manifestations Antibodies  >3 publications with GRIA2 and Neurobehavioral Manifestations
 Mood Disorders Antibodies  >3 publications with GRIA2 and Mood Disorders
 Bipolar Disorder Antibodies  >3 publications with GRIA2 and Bipolar Disorder
 Brain Diseases Antibodies  >3 publications with GRIA2 and Brain Diseases
 Disease Models, Animal Antibodies  >2 publications with GRIA2 and Disease Models, Animal
 Depressive Disorder, Major Antibodies  >2 publications with GRIA2 and Depressive Disorder, Major
 Pain Antibodies  >2 publications with GRIA2 and Pain
 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >20 publications with GRIA2 and Brain
 Blood Antibodies  >2 publications with GRIA2 and Blood
 Liver Antibodies  >1 publications with GRIA2 and Liver
 Heart Antibodies  >1 publications with GRIA2 and Heart
 Muscle Antibodies  >1 publications with GRIA2 and Muscle
 Lung Antibodies  >1 publications with GRIA2 and Lung
Table BarTOPTable Bar
horiz bar
 SSL   Follow us on Facebook Follow us onTwitter Follow us on Google Plus Connect us on LinkedIn Subscribe to our RSS Feed for latest products and special promotions