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GRIA3 recombinant protein :: Glutamate receptor 3 Recombinant Protein

Scan QR to view Datasheet Catalog #    MBS951465
SDS-PAGE
Unit / Price
0.01 mg (E-Coli)  /  $110 +1 FREE 8GB USB
0.01 mg (Yeast)  /  $110 +1 FREE 8GB USB
0.05 mg (E-Coli)  /  $190 +1 FREE 8GB USB
0.05 mg (Yeast)  /  $190 +1 FREE 8GB USB
0.1 mg (E-Coli)  /  $285 +1 FREE 8GB USB
0.1 mg (Yeast)  /  $285 +1 FREE 8GB USB
0.2 mg (E-Coli)  /  $460 +1 FREE 8GB USB
0.2 mg (Yeast)  /  $460 +1 FREE 8GB USB
0.5 mg (Yeast)  /  $750 +1 FREE 8GB USB
0.5 mg (E-Coli)  /  $750 +1 FREE 8GB USB
0.05 mg (Baculovirus)  /  $820 +1 FREE 8GB USB
0.1 mg (Baculovirus)  /  $1,030 +1 FREE 8GB USB
0.05 mg (Mammalian-Cell)  /  $1,055 +1 FREE 8GB USB
1 mg (E-Coli)  /  $1,180 +1 FREE 8GB USB
1 mg (Yeast)  /  $1,180 +1 FREE 8GB USB
0.5 mg (Baculovirus)  /  $1,500 +1 FREE 8GB USB
0.1 mg (Mammalian-Cell)  /  $1,615 +2 FREE 8GB USB
1 mg (Baculovirus)  /  $2,010 +2 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Glutamate receptor 3 (GRIA3), Recombinant Protein

★Popular Item★
 Also Known As   

Recombinant Human Glutamate receptor 3

 Product Synonym Names    AMPA-selective glutamate receptor 3; GluR-C; GluR-K3; Glutamate receptor ionotropic, AMPA 3; GluA3
 Product Gene Name   

GRIA3 recombinant protein

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Sequence Positions    151-250aa; Partial
 Sequence    SLLGHYKWEK FVYLYDTERG FSILQAIMEA AVQNNWQVTA RSVGNIKDVQ EFRRIIEEMD RRQEKRYLID CEVERINTIL EQVVILGKHS RGYHYMLANL
 OMIM    300699
 3D Structure    ModBase 3D Structure for P42263
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 Host    E Coli or Yeast or Baculovirus or Mammalian Cell
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 Purity/Purification    Greater than 90% as determined by SDS-PAGE. (lot specific)
 Form/Format    Liquid containing glycerol
 Tag Information    This protein contains an N-terminal tag and may also contain a C-terminal tag. Tag types are determined by various factors including tag-protein stability, please inquire for tag information.
 Sterility    Sterile filter available upon request.
 Endotoxin    Low endotoxin available upon request.
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 Preparation and Storage    Store at -20 degree C, for extended storage, conserve at -20 degree C or -80 degree C.
 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Other Notes    Small volumes of GRIA3 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for GRIA3 recombinant protein

   Receptor for glutamate that functions as ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. Binding of the excitatory neurotransmitter L-glutamate induces a conformation change, leading to the opening of the cation channel, and thereby converts the chical signal to an electrical impulse. The receptor then desensitizes rapidly and enters a transient inactive state, characterized by the presence of bound agonist. In the presence of CACNG4 or CACNG7 or CACNG8, shows resensitization which is characterized by a delayed accumulation of current flux upon continued application of glutamate.
 Product Categories/Family for GRIA3 recombinant protein    Neuroscience
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 SDS-PAGE of GRIA3 recombinant protein    GRIA3 recombinant protein SDS-PAGE image
(Note: Representative image, actual molecular weight may vary depending on Tag type and expression host)
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NCBI/Uniprot data below describe general gene information for GRIA3. It may not necessarily be applicable to this product.
 NCBI GI #    163659858
 NCBI GeneID    2892
 NCBI Accession #    NP_000819.3 [Other Products]
 NCBI GenBank Nucleotide #    NM_000828.4 [Other Products]
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 UniProt Primary Accession #    P42263 [Other Products]
 UniProt Secondary Accession #    Q4VXD5; Q4VXD6; Q9HDA0; Q9HDA1; Q9HDA2; Q9P0H1; D3DTF1 [Other Products]
 UniProt Related Accession #    P42263 [Other Products]
 Molecular Weight    27.97kD
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 NCBI Official Full Name    glutamate receptor 3 isoform 2
 NCBI Official Synonym Full Names    glutamate ionotropic receptor AMPA type subunit 3
 NCBI Official Symbol    GRIA3 [Similar Products]
 NCBI Official Synonym Symbols   
GLUR3; GLURC; GluA3; MRX94; GLUR-C; GLUR-K3
[Similar Products]
 NCBI Protein Information    glutamate receptor 3
 UniProt Protein Name    Glutamate receptor 3
 UniProt Synonym Protein Names   
AMPA-selective glutamate receptor 3; GluR-C; GluR-K3; Glutamate receptor ionotropic, AMPA 3; GluA3
 Protein Family    Glutamate receptor
 UniProt Gene Name    GRIA3 [Similar Products]
 UniProt Synonym Gene Names    GLUR3; GLURC; GluR-3; GluA3 [Similar Products]
 UniProt Entry Name    GRIA3_HUMAN
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 NCBI Summary for GRIA3    Glutamate receptors are the predominant excitatory neurotransmitter receptors in the mammalian brain and are activated in a variety of normal neurophysiologic processes. These receptors are heteromeric protein complexes composed of multiple subunits, arranged to form ligand-gated ion channels. The classification of glutamate receptors is based on their activation by different pharmacologic agonists. The subunit encoded by this gene belongs to a family of AMPA (alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate)-sensitive glutamate receptors, and is subject to RNA editing (AGA->GGA; R->G). Alternative splicing at this locus results in different isoforms, which may vary in their signal transduction properties. [provided by RefSeq, Jul 2008]
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 UniProt Comments for GRIA3    GluR3: an integral membrane protein belonging to the glutamate-gated ion channel family. L-glutamate (Glu) acts as an excitatory neurotransmitter at many synapses in the central nervous system. Glutamate receptors are heteromeric protein complexes with multiple subunits, each possessing transmembrane regions, and all arranged to form a ligand-gated ion channel. The postsynaptic actions of Glu are mediated by a variety of receptors that are named according to their selective agonists. Interacts with protein kinase C-alpha binding protein. Each of the four GluR proteins (GRIA1-4) include flip and flop isoforms generated by alternative RNA splicing.

Protein type: Membrane protein, multi-pass; Channel, ligand-gated; Membrane protein, integral

Chromosomal Location of Human Ortholog: Xq25

Cellular Component: asymmetric synapse; cell junction; dendritic shaft; dendritic spine; nucleoplasm; perikaryon; plasma membrane; postsynaptic density; postsynaptic membrane; terminal button

Molecular Function: alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity; extracellular-glutamate-gated ion channel activity

Biological Process: glutamate signaling pathway; ionotropic glutamate receptor signaling pathway; synaptic transmission; transport

Disease: Mental Retardation, X-linked, Syndromic, Wu Type
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Product References and Citations for GRIA3 recombinant protein

   Human glutamate receptor hGluR3 flip and flop isoforms cloning and sequencing of the cDNAs and primary structure of the proteins.Rampersad V., Elliott C.E., Nutt S.L., Foldes R.L., Kamboj R.K.Biochim. Biophys. Acta 1219:563-566(1994) McLaughlin D.P., Kerwin R.W. Characterization of the human glutamate receptor subunit 3 gene (GRIA3) , a candidate for bipolar disorder and nonspecific X-linked mental retardation.Gecz J., Barnett S., Liu J., Hollway G., Donnelly A., Eyre H., Eshkevari H.S., Baltazar R., Grunn A., Nagaraja R., Gilliam C., Peltonen L., Sutherland G.R., Baron M., Mulley J.C.Genomics 62:356-368(1999) Candidate gene analysis in Rett syndrome and the identification of 21 SNPs in Xq.Amir R., Dahle E.J., Toriolo D., Zoghbi H.Y.3.3.CO;2-N>Am. J. Med. Genet. 90:69-71(2000) The DNA sequence of the human X chromosome.Ross M.T., Grafham D.V., Coffey A.J., Scherer S., McLay K., Muzny D., Platzer M., Howell G.R., Burrows C., Bird C.P., Frankish A., Lovell F.L., Howe K.L., Ashurst J.L., Fulton R.S., Sudbrak R., Wen G., Jones M.C., Hurles M.E., Andrews T.D., Scott C.E., Searle S., Ramser J., Whittaker A., Deadman R., Carter N.P., Hunt S.E., Chen R., Cree A., Gunaratne P., Havlak P., Hodgson A., Metzker M.L., Richards S., Scott G., Steffen D., Sodergren E., Wheeler D.A., Worley K.C., Ainscough R., Ambrose K.D., Ansari-Lari M.A., Aradhya S., Ashwell R.I., Babbage A.K., Bagguley C.L., Ballabio A., Banerjee R., Barker G.E., Barlow K.F., Barrett I.P., Bates K.N., Beare D.M., Beasley H., Beasley O., Beck A., Bethel G., Blechschmidt K., Brady N., Bray-Allen S., Bridgeman A.M., Brown A.J., Brown M.J., Bonnin D., Bruford E.A., Buhay C., Burch P., Burford D., Burgess J., Burrill W., Burton J., Bye J.M., Carder C., Carrel L., Chako J., Chapman J.C., Chavez D., Chen E., Chen G., Chen Y., Chen Z., Chinault C., Ciccodicola A., Clark S.Y., Clarke G., Clee C.M., Clegg S., Clerc-Blankenburg K., Clifford K., Cobley V., Cole C.G., Conquer J.S., Corby N., Connor R.E., David R., Davies J., Davis C., Davis J., Delgado O., Deshazo D., Dhami P., Ding Y., Dinh H., Dodsworth S., Draper H., Dugan-Rocha S., Dunham A., Dunn M., Durbin K.J., Dutta I., Eades T., Ellwood M., Emery-Cohen A., Errington H., Evans K.L., Faulkner L., Francis F., Frankland J., Fraser A.E., Galgoczy P., Gilbert J., Gill R., Gloeckner G., Gregory S.G., Gribble S., Griffiths C., Grocock R., Gu Y., Gwilliam R., Hamilton C., Hart E.A., Hawes A., Heath P.D., Heitmann K., Hennig S., Hernandez J., Hinzmann B., Ho S., Hoffs M., Howden P.J., Huckle E.J., Hume J., Hunt P.J., Hunt A.R., Isherwood J., Jacob L., Johnson D., Jones S., de Jong P.J., Joseph S.S., Keenan S., Kelly S., Kershaw J.K., Khan Z., Kioschis P., Klages S., Knights A.J., Kosiura A., Kovar-Smith C., Laird G.K., Langford C., Lawlor S., Leversha M., Lewis L., Liu W., Lloyd C., Lloyd D.M., Loulseged H., Loveland J.E., Lovell J.D., Lozado R., Lu J., Lyne R., Ma J., Maheshwari M., Matthews L.H., McDowall J., McLaren S., McMurray A., Meidl P., Meitinger T., Milne S., Miner G., Mistry S.L., Morgan M., Morris S., Mueller I., Mullikin J.C., Nguyen N., Nordsiek G., Nyakatura G., O'dell C.N., Okwuonu G., Palmer S., Pandian R., Parker D., Parrish J., Pasternak S., Patel D., Pearce A.V., Pearson D.M., Pelan S.E., Perez L., Porter K.M., Ramsey Y., Reichwald K., Rhodes S., Ridler K.A., Schlessinger D., Schueler M.G., Sehra H.K., Shaw-Smith C., Shen H., Sheridan E.M., Shownkeen R., Skuce C.D., Smith M.L., Sotheran E.C., Steingruber H.E., Steward C.A., Storey R., Swann R.M., Swarbreck D., Tabor P.E., Taudien S., Taylor T., Teague B., Thomas K., Thorpe A., Timms K., Tracey A., Trevanion S., Tromans A.C., d'Urso M., Verduzco D., Villasana D., Waldron L., Wall M., Wang Q., Warren J., Warry G.L., Wei X., West A., Whitehead S.L., Whiteley M.N., Wilkinson J.E., Willey D.L., Williams G., Williams L., Williamson A., Williamson H., Wilming L., Woodmansey R.L., Wray P.W., Yen J., Zhang J., Zhou J., Zoghbi H., Zorilla S., Buck D., Reinhardt R., Poustka A., Rosenthal A., Lehrach H., Meindl A., Minx P.J., Hillier L.W., Willard H.F., Wilson R.K., Waterston R.H., Rice C.M., Vaudin M., Coulson A., Nelson D.L., Weinstock G., Sulston J.E., Durbin R.M., Hubbard T., Gibbs R.A., Beck S., Rogers J., Bentley D.R.Nature 434:325-337(2005)
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 Research Articles on GRIA3    1. This study demonstrated that the GRIA3 protein was altered in auditory cortex patient with schizophreia.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with GRIA3 recombinant proteinPathways associated with GRIA3 recombinant protein
 Reference Product  PubMed Publications
 GRIA2 recombinant protein  >7 publications with GRIA3 and GRIA2
 Products by Pathway  Pathway Diagram
 Activation Of AMPA Receptors Pathway antibodies  Activation Of AMPA Receptors Pathway Diagram
 Activation Of NMDA Receptor Upon Glutamate Binding And Postsynaptic Events Pathway antibodies  Activation Of NMDA Receptor Upon Glutamate Binding And Postsynaptic Events Pathway Diagram
 Amphetamine Addiction Pathway antibodies  Amphetamine Addiction Pathway Diagram
 Amphetamine Addiction Pathway antibodies  Amphetamine Addiction Pathway Diagram
 BDNF Signaling Pathway antibodies  BDNF Signaling Pathway Diagram
 Circadian Entrainment Pathway antibodies  Circadian Entrainment Pathway Diagram
 Circadian Entrainment Pathway antibodies  Circadian Entrainment Pathway Diagram
 Dopaminergic Synapse Pathway antibodies  Dopaminergic Synapse Pathway Diagram
 Dopaminergic Synapse Pathway antibodies  Dopaminergic Synapse Pathway Diagram
 Glutamate Binding, Activation Of AMPA Receptors And Synaptic Plasticity Pathway antibodies  Glutamate Binding, Activation Of AMPA Receptors And Synaptic Plasticity Pathway Diagram
Diseases associated with GRIA3 recombinant proteinOrgans/Tissues associated with GRIA3 recombinant protein
 Disease Name  Pubmed Publications
 Mental Disorders Antibodies  >22 publications with GRIA3 and Mental Disorders
 Nervous System Diseases Antibodies  >19 publications with GRIA3 and Nervous System Diseases
 Neurobehavioral Manifestations Antibodies  >9 publications with GRIA3 and Neurobehavioral Manifestations
 Brain Diseases Antibodies  >6 publications with GRIA3 and Brain Diseases
 Cell Transformation, Neoplastic Antibodies  >2 publications with GRIA3 and Cell Transformation, Neoplastic
 Sexual Dysfunctions, Psychological Antibodies  >2 publications with GRIA3 and Sexual Dysfunctions, Psychological
 Seizures Antibodies  >1 publications with GRIA3 and Seizures
 Liver Neoplasms Antibodies  >1 publications with GRIA3 and Liver Neoplasms
 Disease Models, Animal Antibodies  >1 publications with GRIA3 and Disease Models, Animal
 Weight Loss Antibodies  >1 publications with GRIA3 and Weight Loss
 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >21 publications with GRIA3 and Brain
 Kidney Antibodies  >1 publications with GRIA3 and Kidney
 Liver Antibodies  >1 publications with GRIA3 and Liver
 Placenta Antibodies  >1 publications with GRIA3 and Placenta
 Vascular Antibodies  >1 publications with GRIA3 and Vascular
 Eye Antibodies  >1 publications with GRIA3 and Eye
 Embryonic Tissue Antibodies  >1 publications with GRIA3 and Embryonic Tissue
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