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GRID2 recombinant protein :: Glutamate receptor delta-2 subunit (GRID2) Recombinant Protein

Scan QR to view Datasheet Catalog #    MBS1173486 GRID2 recombinant protein
Unit / Price
1 mg (E-Coli)  /  $1,375 +1 FREE 8GB USB
1 mg (Yeast)  /  $1,835 +2 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Glutamate receptor delta-2 subunit (GRID2), Recombinant Protein

 Also Known As   

Recombinant Human Glutamate receptor delta-2 subunit (GRID2)

 Product Synonym Names    Recombinant Glutamate receptor delta-2 subunit (GRID2); Glutamate receptor delta-2 subunit; GluR delta-2 subunit
 Product Gene Name   

GRID2 recombinant protein

[Similar Products]
 Product Synonym Gene Name    GRID2; GLURD2 [Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Sequence Positions    24-1007
 Sequence    DSIIHIGAIF DESAKKDDEV FRTAVGDLNQ NEEILQTEKI TFSVTFVDGN NPFQAVQEAC ELMNQGILAL VSSIGCTSAG SLQSLADAMH IPHLFIQRST AGTPRSGCGL TRSNRNDDYT LSVRPPVYLH DVILRVVTEY AWQKFIIFYD SEYDIRGIQE FLDKVSQQGM DVALQKVENN INKMITTLFD TMRIEELNRY RDTLRRAILV MNPATAKSFI TEVVETNLVA FDCHWIIINE EINDVDVQEL VRRSIGRLTI IRQTFPVPQN ISQRCFRGNH RISSTLCDPK DPFAQNMEIS NLYIYDTVLL LANAFHKKLE DRKWHSMASL SCIRKNSKPW QGGRSMLETI KKGGVSGLTG ELEFGENGGN PNVHFEILGT NYGEELGRGV RKLGCWNPVT GLNGSLTDKK LENNMRGVVL RVVTVLEEPF VMVSENVLGK PKKYQGFSID VLDALSNYLG FNYEIYVAPD HKYGSPQEDG TWNGLVGELV FKRADIGISA LTITPDRENV VDFTTRYMDY SVGVLLRRAE KTVDMFACLA PFDLSLWACI AGTVLLVGLL VYLLNWLNPP RLQMGSMTST TLYNSMWFVY GSFVQQGGEV PYTTLATRMM MGAWWLFALI VISSYTANLA AFLTITRIES SIQSLQDLSK QTEIPYGTVL DSAVYEHVRM KGLNPFERDS MYSQMWRMIN RSNGSENNVL ESQAGIQKVK YGNYAFVWDA AVLEYVAIND PDCSFYTIGN TVADRGYGIA LQHGSPYRDV FSQRILELQQ NGDMDILKHK WWPKNGQCDL YSSVDTKQKG GALDIKSFAG VFCILAAGIV LSCFIAMLET WWNKRKGSRV PSKEDDKEID LEHLHRRVNS LCTDDDSPHK QFSTSSIDLT PLDIDTLPTR QALEQISDFR NTHITTTTFI PEQIQTLSRT LSAKAASGFT FGNVPEHRTG PFRHRAPNGG FFRSPIKTMS SIPYQPTPTL GLNLGNDPDR GTSI
 Chromosome Location    Chromosome: 4; NC_000004.11 (93225550..94693649). Location: 4q22
 OMIM    602368
 3D Structure    ModBase 3D Structure for O43424
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 Host    E Coli or Yeast or Baculovirus or Mammalian Cell
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 Purity/Purification    >=90% (lot specific)
 Form/Format    Liquid containing glycerol
 Tag Information    This protein contains an N-terminal tag and may also contain a C-terminal Myc-tag. N-terminal host tags may vary (His, His-SUMO, His-B2M, GST). Tag types are determined by various factors including tag-protein stability and, therefore, are subject to change; please inquire for tag information.
 Sterility    Sterile filter available upon request.
 Endotoxin    Low endotoxin available upon request.
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 Species    Homo sapiens (Human)
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 Preparation and Storage    Store at -20 degree C. For extended storage, store at -20 or -80 degree C.
 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Other Notes    Small volumes of GRID2 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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NCBI/Uniprot data below describe general gene information for GRID2. It may not necessarily be applicable to this product.
 NCBI GI #    157384977
 NCBI GeneID    2895
 NCBI Accession #    NP_001501.2 [Other Products]
 NCBI GenBank Nucleotide #    NM_001510.2 [Other Products]
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 UniProt Primary Accession #    O43424 [Other Products]
 UniProt Secondary Accession #    Q4KKU9; Q4KKV0; Q59FZ1 [Other Products]
 UniProt Related Accession #    O43424 [Other Products]
 Molecular Weight    113,356 Da [Similar Products]
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 NCBI Official Full Name    glutamate receptor delta-2 subunit
 NCBI Official Synonym Full Names    glutamate receptor, ionotropic, delta 2
 NCBI Official Symbol    GRID2 [Similar Products]
 NCBI Official Synonym Symbols   
GluD2
[Similar Products]
 NCBI Protein Information    glutamate receptor delta-2 subunit; GluR-delta-2; gluR delta-2 subunit
 UniProt Protein Name    Glutamate receptor delta-2 subunit
 Protein Family    Glutamate receptor ionotropic
 UniProt Gene Name    GRID2 [Similar Products]
 UniProt Synonym Gene Names    GLURD2; GluR delta-2 subunit [Similar Products]
 UniProt Entry Name    GRID2_HUMAN
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 NCBI Summary for GRID2    Human glutamate receptor delta-2 (GRID2) is a relatively new member of the family of ionotropic glutamate receptors which are the predominant excitatory neurotransmitter receptors in the mammalian brain. GRID2 is a predicted 1,007 amino acid protein that shares 97% identity with the mouse homolog which is expressed selectively in cerebellar Purkinje cells. A point mutation in mouse GRID2, associated with the phenotype named 'lurcher', in the heterozygous state leads to ataxia resulting from selective, cell-autonomous apoptosis of cerebellar Purkinje cells during postnatal development. Mice homozygous for this mutation die shortly after birth from massive loss of mid- and hindbrain neurons during late embryogenesis. This strongly suggests a role for GRID2 in neuronal apoptotic death. [provided by RefSeq, Jul 2008]
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 UniProt Comments for GRID2    GluR-delta2: Receptor for glutamate. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. The postsynaptic actions of Glu are mediated by a variety of receptors that are named according to their selective agonists. Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family. GRID2 subfamily.

Protein type: Membrane protein, integral; Channel, calcium; Channel, ligand-gated; Membrane protein, multi-pass

Chromosomal Location of Human Ortholog: 4q22

Cellular Component: postsynaptic membrane; integral to plasma membrane; dendrite; plasma membrane; dendritic spine; ionotropic glutamate receptor complex; synapse; cell junction

Molecular Function: extracellular-glutamate-gated ion channel activity; ionotropic glutamate receptor activity; glutamate receptor activity; PDZ domain binding

Biological Process: heterophilic cell adhesion; synaptic transmission, glutamatergic; prepulse inhibition; glutamate signaling pathway; ionotropic glutamate receptor signaling pathway; transport; regulation of neuron apoptosis; regulation of excitatory postsynaptic membrane potential; cerebellar granule cell differentiation

Disease: Spinocerebellar Ataxia, Autosomal Recessive 18
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 Research Articles on GRID2    1. Glutamate receptor delta2 is involved in a common mechanism that restricts the number of synaptic AMPA receptors at parallel fiber synapses in cerebellar Purkinje cells.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with GRID2 recombinant proteinPathways associated with GRID2 recombinant protein
 Reference Product  PubMed Publications
 DLG2 recombinant protein  >2 publications with GRID2 and DLG2
 GRIK2 recombinant protein  >1 publications with GRID2 and GRIK2
 GRIA1 recombinant protein  >1 publications with GRID2 and GRIA1
 Products by Pathway  Pathway Diagram
 Long-term Depression Pathway antibodies  Long-term Depression Pathway Diagram
 Long-term Depression Pathway antibodies  Long-term Depression Pathway Diagram
 Neuroactive Ligand-receptor Interaction Pathway antibodies  Neuroactive Ligand-receptor Interaction Pathway Diagram
 Neuroactive Ligand-receptor Interaction Pathway antibodies  Neuroactive Ligand-receptor Interaction Pathway Diagram
Diseases associated with GRID2 recombinant proteinOrgans/Tissues associated with GRID2 recombinant protein
 Disease Name  Pubmed Publications
 Nervous System Diseases Antibodies  >6 publications with GRID2 and Nervous System Diseases
 Brain Diseases Antibodies  >6 publications with GRID2 and Brain Diseases
 Nerve Degeneration Antibodies  >4 publications with GRID2 and Nerve Degeneration
 Neoplasms, Experimental Antibodies  >3 publications with GRID2 and Neoplasms, Experimental
 Movement Disorders Antibodies  >2 publications with GRID2 and Movement Disorders
 Growth Disorders Antibodies  >1 publications with GRID2 and Growth Disorders
 Neurodegenerative Diseases Antibodies  >1 publications with GRID2 and Neurodegenerative Diseases
 Liver Diseases Antibodies  >1 publications with GRID2 and Liver Diseases
 Weight Loss Antibodies  >1 publications with GRID2 and Weight Loss
 Disease Models, Animal Antibodies  >1 publications with GRID2 and Disease Models, Animal
 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >23 publications with GRID2 and Brain
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