Antibody Protein ELISA Kit from MyBioSource header Telephone 1.858.633.0165          
1.855.MyBioSource
Fax 1.858.633.0166    Email sales@mybiosource.com 
tel/fax
menu1 Home Products Ordering Company Help menu7
bottom
   MyBioSource rightarrow Recombinant Protein rightarrow GLUL  rightarrow LOG IN  rightarrow MY ACCOUNT  rightarrow CART CONTENTS  rightarrow CHECKOUT 
horiz bar
MyBioSource Menu separator
separator
ELISA Kit ELISA Kit
CLIA Kit CLIA Kit
PCR Kit PCR Kit
Monoclonal Antibody Monoclonal Antibody
Polyclonal Antibody Polyclonal Antibody
Secondary Antibody Secondary Antibody
Antigen Antigen
Biochemical Biochemical
cDNA Clone cDNA Clone
siRNA siRNA
Peptide Peptide
Recombinant/Purified Protein Rec./Purified Protein

Custom ELISA Kit Custom ELISA Kit
Custom Protein Custom Protein
Custom Antibody Custom Antibody
Antibody Matched Pairs Antibody Matched Pairs
Antibody & Corresponding Blocking Peptide Pairs Antibody Peptide Pairs
Phospho-Specific Antibodies Phospho Antibodies
Products by Disease Products by Disease
Products by Pathway Products by Pathway
Products by Tissue Products by Tissue

arrow Advanced Search
arrow Submit Technical Q&A
arrow International Distributors
arrow Contact Us
separator
Our Best Sellers moreseparator
separator
 • CD28 Antibody
 • Ki-67 Antibody
 • HLA B27 Antibody
 • FABP5 Antibody
 • CD141 Recombinant Protein
 • Fibroblast growth factor 15 (Fgf15) ELISA Kit
 • Hexokinase 3 (HK3) Antibody
 • TM4SF20 Antibody
 • RASSF1A Antibody
 • CS ELISA Kit
 • albumin ELISA Kit
 • Pyrin - MEFV - MEF Antibody
 • nephroblastoma overexpressed gene (NOV) ELISA Kit
 • Integrin alpha-M (Itgam-CD11b) ELISA Kit
 downarrow more ...
separator
separator
DatasheetFull DatasheetPrinter Friendly DatasheetPrint This DatasheetAdd to Compare ListHave Questions? Ask UsRequest for a Quotation today

GLUL recombinant protein :: Glutamine Synthetase Recombinant Protein

Scan QR to view Datasheet Catalog #    MBS143992 GLUL recombinant protein
Unit / Price
0.005 mg  /  $140 +1 FREE 8GB USB
0.02 mg  /  $205 +1 FREE 8GB USB
1 mg  /  $2,665 +3 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Glutamine Synthetase (GLUL), Recombinant Protein

★Popular Item★
 Also Known As   

Recombinant Human Glutamine Synthetase

 Product Synonym Names    GLUL Human; Glutamine Synthetase Human Recombinant; GLNS; EC 6.3.1.2; EC 4.1.1.15; GLUL; Glutamine Synthetase; GS; Glutamate decarboxylase; Glutamate--ammonia ligase; PIG43; PIG59
 Product Gene Name   

GLUL recombinant protein

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
Table BarTOPTable Bar
 Sequence    MGSSHHH HHH SSGLVPRGSH MTTSASSHLN KGIKQVYMSL PQGEKVQAMY IWIDGTGEGL RCKTRTLDSE PKCVEELPEW NFDGSSTLQS EGSNSDMYLV PAAMFRDPFR KDPNKLVLCE VFKYNRRPAE TNLRHTCKRI MDMVSNQHPW FGMEQEYTLM GTDGHPFGWP SNGFPGPQGP YYCGVGADRA YGRDIVEAHY RACLYAGVKI AGTNAEVMPA QWEFQIGPCE GISMGDHLWV ARFILHRVCE DFGVIATFDP KPIPGNWNGA GCHTNFSTKA MREENGLKYI EEAIEKLSKR HQYHIRAYDP KGGLDNARRL TGFHETSNIN DFSAGVANRS ASIRIPRTVG QEKKGYFEDR RPSANCDPFS VTEALIRTCL LNETGDEPFQ YKN
 OMIM    138290
 3D Structure    ModBase 3D Structure for P15104
Section Bar
 Host    E Coli
Section Bar
 Purity/Purification    Greater than 90.0% as determined by SDS-PAGE.
 Form/Format    GLUL Human solution containing 20mM Tris-HCl pH-8, 5mM DTT, 0.2M NaCl & 20% glycerol.
Sterile filtered colorless solution.
Section Bar
Section Bar
 Other Notes    Small volumes of GLUL recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Table BarTOPTable Bar
 

Related Product Information for GLUL recombinant protein

   Description: GLUL Recombinant Human produced in E Coli is a single, non-glycosylated polypeptide chain containing 393 amino acids (1-373 a.a.) and having a molecular mass of 44.2 kDa. The GLUL is fused to a 20 amino acid His-Tag at N-terminus and purified by proprietary chromatographic techniques.

Introduction: GLUL catalyzes the synthesis of glutamine from glutamate and ammonia. Glutamine is a major source of energy and that takes part in cell proliferation, inhibition of apoptosis, and cell signaling. GLUL is expressed during early fetal stages, and has a role in maintaining body pH by removing ammonia from circulation. Mutations in GLUL gene are related with congenital glutamine deficiency.
 Product Categories/Family for GLUL recombinant protein    ENZYMES; Enzymes; Synthetase
NCBI/Uniprot data below describe general gene information for GLUL. It may not necessarily be applicable to this product.
 NCBI GI #    74271837
 NCBI GeneID    2752
 NCBI Accession #    NP_001028216.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_001033044.3 [Other Products]
Section Bar
 UniProt Primary Accession #    P15104 [Other Products]
 UniProt Secondary Accession #    Q499Y9; Q5T9Z1; Q7Z3W4; Q8IZ17 [Other Products]
 UniProt Related Accession #    P15104 [Other Products]
 Molecular Weight    42,064 Da
Table BarTOPTable Bar
 NCBI Official Full Name    glutamine synthetase
 NCBI Official Synonym Full Names    glutamate-ammonia ligase
 NCBI Official Symbol    GLUL [Similar Products]
 NCBI Official Synonym Symbols   
GS; GLNS; PIG43; PIG59
[Similar Products]
 NCBI Protein Information    glutamine synthetase; cell proliferation-inducing protein 59; glutamate decarboxylase; glutamine synthase; proliferation-inducing protein 43
 UniProt Protein Name    Glutamine synthetase
 UniProt Synonym Protein Names   
Glutamate decarboxylase (EC:4.1.1.15); Glutamate--ammonia ligase
 Protein Family    Glutamine synthetase
 UniProt Gene Name    GLUL [Similar Products]
 UniProt Synonym Gene Names    GLNS; GS [Similar Products]
 UniProt Entry Name    GLNA_HUMAN
Section Bar
 NCBI Summary for GLUL    The protein encoded by this gene belongs to the glutamine synthetase family. It catalyzes the synthesis of glutamine from glutamate and ammonia in an ATP-dependent reaction. This protein plays a role in ammonia and glutamate detoxification, acid-base homeostasis, cell signaling, and cell proliferation. Glutamine is an abundant amino acid, and is important to the biosynthesis of several amino acids, pyrimidines, and purines. Mutations in this gene are associated with congenital glutamine deficiency, and overexpression of this gene was observed in some primary liver cancer samples. There are six pseudogenes of this gene found on chromosomes 2, 5, 9, 11, and 12. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2014]
Section Bar
 UniProt Comments for GLUL    GLUL: This enzyme has 2 functions: it catalyzes the production of glutamine and 4-aminobutanoate (gamma-aminobutyric acid, GABA), the latter in a pyridoxal phosphate-independent manner. Essential for proliferation of fetal skin fibroblasts. Defects in GLUL are the cause of congenital systemic glutamine deficiency (CSGD). CSGD is a rare developmental disorder with severe brain malformation resulting in multi-organ failure and neonatal death. Glutamine is largely absent from affected patients serum, urine and cerebrospinal fluid. Belongs to the glutamine synthetase family.

Protein type: Energy Metabolism - nitrogen; Amino Acid Metabolism - alanine, aspartate and glutamate; EC 6.3.1.2; Amino Acid Metabolism - arginine and proline; Ligase; EC 4.1.1.15

Chromosomal Location of Human Ortholog: 1q31

Cellular Component: protein complex; mitochondrion; rough endoplasmic reticulum; cytoplasm; perikaryon; nerve terminal; nucleus; cytosol

Molecular Function: glutamate-ammonia ligase activity; identical protein binding; dynein light chain binding; glutamate binding; glutamate decarboxylase activity; manganese ion binding; magnesium ion binding; ATP binding

Biological Process: cell proliferation; glutamate catabolic process; synaptic transmission; glutamine biosynthetic process; response to glucose stimulus; positive regulation of insulin secretion; neurotransmitter uptake; amino acid biosynthetic process; cellular response to starvation; positive regulation of synaptic transmission, glutamatergic; positive regulation of epithelial cell proliferation; protein homooligomerization

Disease: Glutamine Deficiency, Congenital
Table BarTOPTable Bar
 Research Articles on GLUL    1. Results highlight the diagnostic errors that can be caused by variant patterns of staining with glutamine synthetase and serum amyloid-associated protein in inflammatory hepatocellular adenoma and focal nodular hyperplasia.
Table BarTOPTable Bar
 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
Table BarTOPTable Bar
Products associated with GLUL recombinant proteinPathways associated with GLUL recombinant protein
 Reference Product  PubMed Publications
 CPS1 recombinant protein  >3 publications with GLUL and CPS1
 GLUD1 recombinant protein  >3 publications with GLUL and GLUD1
 GLS recombinant protein  >3 publications with GLUL and GLS
 GAD2 recombinant protein  >2 publications with GLUL and GAD2
 GLS2 recombinant protein  >1 publications with GLUL and GLS2
 Products by Pathway  Pathway Diagram
 Alanine, Aspartate And Glutamate Metabolism Pathway antibodies  Alanine, Aspartate And Glutamate Metabolism Pathway Diagram
 Alanine, Aspartate And Glutamate Metabolism Pathway antibodies  Alanine, Aspartate And Glutamate Metabolism Pathway Diagram
 Amino Acid Synthesis And Interconversion (transamination) Pathway antibodies  Amino Acid Synthesis And Interconversion (transamination) Pathway Diagram
 Arginine And Proline Metabolism Pathway antibodies  Arginine And Proline Metabolism Pathway Diagram
 Arginine And Proline Metabolism Pathway antibodies  Arginine And Proline Metabolism Pathway Diagram
 Astrocytic Glutamate-Glutamine Uptake And Metabolism Pathway antibodies  Astrocytic Glutamate-Glutamine Uptake And Metabolism Pathway Diagram
 Biosynthesis Of Amino Acids Pathway antibodies  Biosynthesis Of Amino Acids Pathway Diagram
 Biosynthesis Of Amino Acids Pathway antibodies  Biosynthesis Of Amino Acids Pathway Diagram
 GABA Shunt Pathway antibodies  GABA Shunt Pathway Diagram
 GABAergic Synapse Pathway antibodies  GABAergic Synapse Pathway Diagram
Diseases associated with GLUL recombinant proteinOrgans/Tissues associated with GLUL recombinant protein
 Disease Name  Pubmed Publications
 Liver Diseases Antibodies  >7 publications with GLUL and Liver Diseases
 Liver Neoplasms Antibodies  >7 publications with GLUL and Liver Neoplasms
 Brain Diseases Antibodies  >4 publications with GLUL and Brain Diseases
 Carcinoma, Hepatocellular Antibodies  >4 publications with GLUL and Carcinoma, Hepatocellular
 Neoplasms, Experimental Antibodies  >2 publications with GLUL and Neoplasms, Experimental
 Heart Diseases Antibodies  >2 publications with GLUL and Heart Diseases
 Liver Neoplasms, Experimental Antibodies  >2 publications with GLUL and Liver Neoplasms, Experimental
 Memory Disorders Antibodies  >1 publications with GLUL and Memory Disorders
 Cognition Disorders Antibodies  >1 publications with GLUL and Cognition Disorders
 Fatty Liver Antibodies  >1 publications with GLUL and Fatty Liver
 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >16 publications with GLUL and Brain
 Liver Antibodies  >11 publications with GLUL and Liver
 Eye Antibodies  >6 publications with GLUL and Eye
 Blood Antibodies  >5 publications with GLUL and Blood
 Nerve Antibodies  >5 publications with GLUL and Nerve
 Kidney Antibodies  >4 publications with GLUL and Kidney
 Pancreas Antibodies  >3 publications with GLUL and Pancreas
 Mammary Gland Antibodies  >2 publications with GLUL and Mammary Gland
 Lung Antibodies  >2 publications with GLUL and Lung
 Heart Antibodies  >2 publications with GLUL and Heart
Table BarTOPTable Bar
horiz bar
 SSL   Follow us on Facebook Follow us onTwitter Follow us on Google Plus Connect us on LinkedIn Subscribe to our RSS Feed for latest products and special promotions