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GLRX recombinant protein :: Glutaredoxin-1 Recombinant Protein

Scan QR to view Datasheet Catalog #    MBS203286
Unit / Price
0.1 mg  /  $255 +1 FREE 8GB USB
0.5 mg  /  $535 +1 FREE 8GB USB
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Glutaredoxin-1 (GLRX), Recombinant Protein

★Popular Item★
 Also Known As   

Glutaredoxin-1,1-106aa, Human, Recombinant, E Coli

 Product Synonym Names    GLRX; GRX; GRX1; Thioltransferase-1; TTase-1; Glrx1; Glutaredoxin; Glutaredoxin1; Grx 1; MGC117407; Thioltransferase; Thioltransferase 1; Thioltransferase1; Ttase; TTase 1; TTase1.
 Product Gene Name   

GLRX recombinant protein

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Purity/Purification    > 95% by SDS - PAGE
 Form/Format    Liquid. In 20 mM Tris-HCl buffer (pH 8.0) containing 1 mM DTT 10% glycerol
 Concentration    1 mg/ml (determined by Bradford assay) (lot specific)
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 Antigen Species    Human
 Expression System    E Coli
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 Preparation and Storage    Can be stored at 4 degree C short term (1-2 weeks). For long term storage, aliquot and store at -20 degree C or -70 degree C. Avoid repeated freezing and thawing cycles.
 Other Notes    Small volumes of GLRX recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Product Description specifically for GLRX recombinant protein

   Description: Glutaredoxin(GRX), also known as thioltransferase, is member of the thiol-disulfide oxidoreductase family. Glutraredoxin catalyzes the reversible reduction of protein-glutathionyl mixed disulfides to free sulfhydryl groups though a monothiol mechanism. Mammalian Glutaredoxin is known to have two isoforms, GRX1 and GRX2. GRX1 is a cytosolic protein, whereas GRX2 is localized both in the mitochondria and nucleus. Glutaredoxin-1 may be involved in a various cellular events such as signal transduction, stress response, and metabolic regulation by regulating the redox status of cellular proteins. Recombinant human Glutaredoxin1 protein was expressed in E.coli and purified by using conventional chromatography techniques.
 Product Categories/Family for GLRX recombinant protein    Redox Proteins
 Applications Tested/Suitable for GLRX recombinant protein   


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 SDS-PAGE of GLRX recombinant protein    GLRX recombinant protein SDS-PAGE image
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NCBI/Uniprot data below describe general gene information for GLRX. It may not necessarily be applicable to this product.
 NCBI GI #    4504025
 NCBI GeneID    2745
 NCBI Accession #    NP_002055 [Other Products]
 NCBI GenBank Nucleotide #    NM_002064.2 [Other Products]
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 UniProt Secondary Accession #    Q3KQS1; Q6ICT1; B2R4L2 [Other Products]
 UniProt Related Accession #    P35754 [Other Products]
 Molecular Weight    11.7 kDa (106 aa), confirmed by MALDI-TOF. [Similar Products]
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 NCBI Official Full Name    glutaredoxin-1
 NCBI Official Synonym Full Names    glutaredoxin (thioltransferase)
 NCBI Official Symbol    GLRX [Similar Products]
 NCBI Official Synonym Symbols   
[Similar Products]
 NCBI Protein Information    glutaredoxin-1; TTase-1; thioltransferase-1
 UniProt Protein Name    Glutaredoxin-1
 UniProt Synonym Protein Names   
Thioltransferase-1; TTase-1
 Protein Family    Glutaredoxin
 UniProt Gene Name    GLRX [Similar Products]
 UniProt Synonym Gene Names    GRX; TTase-1 [Similar Products]
 UniProt Entry Name    GLRX1_HUMAN
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 NCBI Summary for GLRX    This gene encodes a member of the glutaredoxin family. The encoded protein is a cytoplasmic enzyme catalyzing the reversible reduction of glutathione-protein mixed disulfides. This enzyme highly contributes to the antioxidant defense system. It is crucial for several signalling pathways by controlling the S-glutathionylation status of signalling mediators. It is involved in beta-amyloid toxicity and Alzheimer's disease. Multiple alternatively spliced transcript variants encoding the same protein have been identified. [provided by RefSeq, Aug 2011]
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 UniProt Comments for GLRX    GLRX1: Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins. Belongs to the glutaredoxin family.

Protein type: Oxidoreductase

Chromosomal Location of Human Ortholog: 5q14

Cellular Component: mitochondrion; nucleus; cytosol

Molecular Function: electron carrier activity; protein N-terminus binding; glutathione disulfide oxidoreductase activity

Biological Process: nucleobase, nucleoside and nucleotide interconversion; nucleobase, nucleoside and nucleotide metabolic process; cell redox homeostasis; positive regulation of membrane potential
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Product References and Citations for GLRX recombinant protein

   Reynaert NL., et al. (2006) Proc Natl Acad Sci u S A. 103(35):13086-91.
Kanda M., et al. (2006) J Biol Chem. 281(39):28518-28.
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 Research Articles on GLRX    1. Human Grx1 can catalyse reduction of Atox1 by glutathione but only in the presence of Cu(I).
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with GLRX recombinant proteinPathways associated with GLRX recombinant protein
 Reference Product  PubMed Publications
 MAP3K5 recombinant protein  >3 publications with GLRX and MAP3K5
 TXN recombinant protein  >1 publications with GLRX and TXN
 CASP3 recombinant protein  >1 publications with GLRX and CASP3
 Products by Pathway  Pathway Diagram
 Metabolism Pathway antibodies  Metabolism Pathway Diagram
 Metabolism Of Nucleotides Pathway antibodies  Metabolism Of Nucleotides Pathway Diagram
 Synthesis And Interconversion Of Nucleotide Di- And Triphosphates Pathway antibodies  Synthesis And Interconversion Of Nucleotide Di- And Triphosphates Pathway Diagram
 Ascorbate Recycling (cytosolic) Pathway antibodies  Ascorbate Recycling (cytosolic) Pathway Diagram
 Ascorbate Recycling (cytosolic) Pathway antibodies  Ascorbate Recycling (cytosolic) Pathway Diagram
Diseases associated with GLRX recombinant proteinOrgans/Tissues associated with GLRX recombinant protein
 Disease Name  Pubmed Publications
 Disease Models, Animal Antibodies  >8 publications with GLRX and Disease Models, Animal
 Cardiovascular Diseases Antibodies  >8 publications with GLRX and Cardiovascular Diseases
 Inflammation Antibodies  >7 publications with GLRX and Inflammation
 Lung Diseases Antibodies  >6 publications with GLRX and Lung Diseases
 Nervous System Diseases Antibodies  >4 publications with GLRX and Nervous System Diseases
 Necrosis Antibodies  >4 publications with GLRX and Necrosis
 Heart Diseases Antibodies  >3 publications with GLRX and Heart Diseases
 Anemia Antibodies  >2 publications with GLRX and Anemia
 Hypertrophy Antibodies  >2 publications with GLRX and Hypertrophy
 Brain Diseases Antibodies  >2 publications with GLRX and Brain Diseases
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >14 publications with GLRX and Blood
 Muscle Antibodies  >11 publications with GLRX and Muscle
 Lung Antibodies  >9 publications with GLRX and Lung
 Vascular Antibodies  >9 publications with GLRX and Vascular
 Eye Antibodies  >9 publications with GLRX and Eye
 Heart Antibodies  >8 publications with GLRX and Heart
 Liver Antibodies  >6 publications with GLRX and Liver
 Embryonic Tissue Antibodies  >4 publications with GLRX and Embryonic Tissue
 Placenta Antibodies  >4 publications with GLRX and Placenta
 Brain Antibodies  >3 publications with GLRX and Brain
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