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GLRX1 recombinant protein :: Glutaredoxin 1 Recombinant Protein

Scan QR to view Datasheet Catalog #    MBS143601 GLRX1 recombinant protein
Unit / Price
0.01 mg  /  $140 +1 FREE 8GB USB
0.05 mg  /  $205 +1 FREE 8GB USB
1 mg  /  $1,800 +2 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Glutaredoxin 1 (GLRX1), Recombinant Protein

 Also Known As   

Recombinant Human Glutaredoxin 1

 Product Synonym Names    GLRX1 Human; Glutaredoxin 1 Human Recombinant; Thioltransferase; GRX; GLRX1; GRX1; GRX-1; GLRX-1; Glutathione-dependent oxidoreductase 1; Glutaredoxin-1; Thioltransferase-1; TTase-1; GLRX; MGC117407
 Product Gene Name   

GLRX1 recombinant protein

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Sequence    MAQEFVNCKI QPGKVVVFIK PTCPYCRRAQ EILSQLPIKQ GLLEFVDITA TNHTNEIQDY LQQLTGARTV PRVFIGKDCI GGCSDLVSLQ QSGELLTRLK QIGALQ
 OMIM    600443
 3D Structure    ModBase 3D Structure for P35754
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 Host    E Coli
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 Purity/Purification    Greater than 95% as determined by SDS-PAGE.
 Form/Format    Glutaredoxin solution contains 20 mM Tris-HCl pH-8, 1mM DTT & 10% Glycerol.
Sterile Filtered clear colorless solution.
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 Preparation and Storage    Store at 4 degree C if entire vial will be used within 2-4 weeks. Store, frozen at -20 degree C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.
 Other Notes    Small volumes of GLRX1 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for GLRX1 recombinant protein

   Description: Glutaredoxin Human Recombinant produced in E Coli is a single, non-glycosylated, Polypeptide chain containing 106 amino acids having a molecular mass of 11.7 kDa.

Introduction: GLRX1 has a glutathione-disulfide oxidoreductase activity in the presence of nadph and glutathione reductase. reduces low molecular weight disulfides and proteins. Glutaredoxin is a glutathione (GSH)-dependent hydrogen donor for ribonucleotide reductase and also catalyzes glutathione-disulfide oxidoreduction reactions in the presence of NADPH and glutathione reductase. GLRX1 is multifunctional enzyme with glutathione-dependent oxidoreductase, glutathione peroxidase and glutathione S-transferase (GST) activity. The disulfide bond functions as an electron carrier in the glutathione-dependent synthesis of deoxyribonucleotides by the enzyme ribonucleotide reductase. In addition, it is also involved in reducing cytosolic protein- and non-protein-disulfides in a coupled system with glutathione reductase. Required for resistance to reactive oxygen species (ROS) by directly reducing hydroperoxides and for the detoxification of ROS-mediated damage.
 Product Categories/Family for GLRX1 recombinant protein    ENZYMES; Enzymes; Gluteradoxin
NCBI/Uniprot data below describe general gene information for GLRX1. It may not necessarily be applicable to this product.
 NCBI GI #    169646776
 NCBI GeneID    2745
 NCBI Accession #    NP_001112362.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_001118890.1 [Other Products]
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 UniProt Primary Accession #    P35754 [Other Products]
 UniProt Secondary Accession #    Q3KQS1; Q6ICT1; B2R4L2 [Other Products]
 UniProt Related Accession #    P35754 [Other Products]
 Molecular Weight    11,776 Da
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 NCBI Official Full Name    glutaredoxin-1
 NCBI Official Synonym Full Names    glutaredoxin (thioltransferase)
 NCBI Official Symbol    GLRX [Similar Products]
 NCBI Official Synonym Symbols   
GRX; GRX1
[Similar Products]
 NCBI Protein Information    glutaredoxin-1; TTase-1; thioltransferase-1
 UniProt Protein Name    Glutaredoxin-1
 UniProt Synonym Protein Names   
Thioltransferase-1; TTase-1
 UniProt Gene Name    GLRX [Similar Products]
 UniProt Synonym Gene Names    GRX; TTase-1 [Similar Products]
 UniProt Entry Name    GLRX1_HUMAN
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 NCBI Summary for GLRX1    This gene encodes a member of the glutaredoxin family. The encoded protein is a cytoplasmic enzyme catalyzing the reversible reduction of glutathione-protein mixed disulfides. This enzyme highly contributes to the antioxidant defense system. It is crucial for several signalling pathways by controlling the S-glutathionylation status of signalling mediators. It is involved in beta-amyloid toxicity and Alzheimer's disease. Multiple alternatively spliced transcript variants encoding the same protein have been identified. [provided by RefSeq, Aug 2011]
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 UniProt Comments for GLRX1    GLRX1: Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins. Belongs to the glutaredoxin family.

Protein type: Oxidoreductase

Chromosomal Location of Human Ortholog: 5q14

Cellular Component: mitochondrion; cytosol; nucleus

Molecular Function: electron carrier activity; protein N-terminus binding; glutathione disulfide oxidoreductase activity

Biological Process: nucleobase, nucleoside and nucleotide metabolic process; nucleobase, nucleoside and nucleotide interconversion; cell redox homeostasis; positive regulation of membrane potential
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 Research Articles on GLRX1    1. Human Grx1 can catalyse reduction of Atox1 by glutathione but only in the presence of Cu(I).
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with GLRX1 recombinant proteinPathways associated with GLRX1 recombinant protein
 Reference Product  PubMed Publications
 MAP3K5 recombinant protein  >3 publications with GLRX1 and MAP3K5
 TXN recombinant protein  >1 publications with GLRX1 and TXN
 CASP3 recombinant protein  >1 publications with GLRX1 and CASP3
 Products by Pathway  Pathway Diagram
 Metabolism Pathway antibodies  Metabolism Pathway Diagram
 Metabolism Of Nucleotides Pathway antibodies  Metabolism Of Nucleotides Pathway Diagram
 Synthesis And Interconversion Of Nucleotide Di- And Triphosphates Pathway antibodies  Synthesis And Interconversion Of Nucleotide Di- And Triphosphates Pathway Diagram
 Ascorbate Recycling (cytosolic) Pathway antibodies  Ascorbate Recycling (cytosolic) Pathway Diagram
 Ascorbate Recycling (cytosolic) Pathway antibodies  Ascorbate Recycling (cytosolic) Pathway Diagram
Diseases associated with GLRX1 recombinant proteinOrgans/Tissues associated with GLRX1 recombinant protein
 Disease Name  Pubmed Publications
 Disease Models, Animal Antibodies  >8 publications with GLRX1 and Disease Models, Animal
 Cardiovascular Diseases Antibodies  >8 publications with GLRX1 and Cardiovascular Diseases
 Inflammation Antibodies  >7 publications with GLRX1 and Inflammation
 Lung Diseases Antibodies  >6 publications with GLRX1 and Lung Diseases
 Nervous System Diseases Antibodies  >4 publications with GLRX1 and Nervous System Diseases
 Necrosis Antibodies  >4 publications with GLRX1 and Necrosis
 Heart Diseases Antibodies  >3 publications with GLRX1 and Heart Diseases
 Anemia Antibodies  >2 publications with GLRX1 and Anemia
 Hypertrophy Antibodies  >2 publications with GLRX1 and Hypertrophy
 Brain Diseases Antibodies  >2 publications with GLRX1 and Brain Diseases
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >14 publications with GLRX1 and Blood
 Muscle Antibodies  >11 publications with GLRX1 and Muscle
 Lung Antibodies  >9 publications with GLRX1 and Lung
 Vascular Antibodies  >9 publications with GLRX1 and Vascular
 Eye Antibodies  >9 publications with GLRX1 and Eye
 Heart Antibodies  >8 publications with GLRX1 and Heart
 Liver Antibodies  >6 publications with GLRX1 and Liver
 Embryonic Tissue Antibodies  >4 publications with GLRX1 and Embryonic Tissue
 Placenta Antibodies  >4 publications with GLRX1 and Placenta
 Brain Antibodies  >3 publications with GLRX1 and Brain
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