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GLRX3 recombinant protein :: Glutaredoxin-3 Recombinant Protein

Scan QR to view Datasheet Catalog #    MBS203427
Unit / Price
0.1 mg  /  $285 +1 FREE 8GB USB
0.5 mg  /  $640 +1 FREE 8GB USB
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Glutaredoxin-3 (GLRX3), Recombinant Protein

★Popular Item★
 Also Known As   

Glutaredoxin-3, 1-335aa, Human, His tag, E Coli

 Product Synonym Names    Thioredoxin-like protein 2; GLRX3; PICOT; TXNL2; GRX3; glutaredoxin 4; bA500G10.4; GLRX4; GRX4; thioredoxin-like 2; thioredoxin-like 2; glutaredoxin 3
 Product Gene Name   

GLRX3 recombinant protein

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    AF118649 mRNA
 3D Structure    ModBase 3D Structure for O76003
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 Host    E Coli
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 Purity/Purification    > 95% by SDS-PAGE
 Form/Format    Liquid. 20mM Tris-HCl Buffer (pH 8.0) containing 10% glycerol, 1mM DTT
 Concentration    0.5 mg/ml (determined by Bradford assay) (lot specific)
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 Antigen Species    Human
 Tag Information    His-tag
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 Preparation and Storage    Can be stored at 4 degree C short term (1-2 weeks).
For long term storage, aliquot and store at -20 degree C or -70 degree C.
Avoid repeated freezing and thawing cycles.
 Other Notes    Small volumes of GLRX3 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for GLRX3 recombinant protein

   Glutaredoxin (GRX), also known as thioltransferase, is member of the thiol-disulfide oxidoreductase family. Glutraredoxin catalyzes the reversible reduction of protein-glutathionyl mixed disulfides to free sulfhydryl groups though a monothiol mechanism. Glutaredoxin-3 (Grx3/PICOT) is an essential protein involved in the regulation of signal transduction, for instance during immune cell activation and development of cardiac hypertrophy, presumably in response to redox signals. And it has been shown to interact with PRKCQ. Recombinant human Glutaredoxin-3, fused to His-tag at N-terminus, was expressed in E Coli and purified by using conventional chromatography techniques.
 Product Categories/Family for GLRX3 recombinant protein    Redox Proteins
 Applications Tested/Suitable for GLRX3 recombinant protein   


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 SDS-Page of GLRX3 recombinant protein    GLRX3 recombinant protein SDS-Page image
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NCBI/Uniprot data below describe general gene information for GLRX3. It may not necessarily be applicable to this product.
 NCBI GI #    95113651
 NCBI GeneID    10539
 NCBI Accession #    NP_006532 [Other Products]
 NCBI GenBank Nucleotide #    NM_006541.4 [Other Products]
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 UniProt Primary Accession #    O76003 [Other Products]
 UniProt Secondary Accession #    Q5JV01; Q96CE0; Q9P1B0; Q9P1B1; B3KMP7; B3KMQ5; D3DRG2 [Other Products]
 UniProt Related Accession #    O76003 [Other Products]
 Molecular Weight    39.6kDa (355aa), confirmed by MALDI-TOF [Similar Products]
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 NCBI Official Full Name    glutaredoxin-3 isoform 1
 NCBI Official Synonym Full Names    glutaredoxin 3
 NCBI Official Symbol    GLRX3 [Similar Products]
 NCBI Official Synonym Symbols   
[Similar Products]
 NCBI Protein Information    glutaredoxin-3
 UniProt Protein Name    Glutaredoxin-3
 UniProt Synonym Protein Names   
PKC-interacting cousin of thioredoxin
 Protein Family    Glutaredoxin
 UniProt Gene Name    GLRX3 [Similar Products]
 UniProt Synonym Gene Names    ; PKCq-interacting protein [Similar Products]
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 NCBI Summary for GLRX3    This gene encodes a member of the glutaredoxin family. Glutaredoxins are oxidoreductase enzymes that reduce a variety of substrates using glutathione as a cofactor. The encoded protein binds to and modulates the function of protein kinase C theta. The encoded protein may also inhibit apoptosis and play a role in cellular growth, and the expression of this gene may be a marker for cancer. Pseudogenes of this gene are located on the short arm of chromosomes 6 and 9. Alternatively spliced transcript variants have been observed for this gene. [provided by RefSeq, Dec 2010]
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 UniProt Comments for GLRX3    Together with BOLA2, acts as a cytosolic iron-sulfur (Fe-S) cluster assembly factor that facilitates [2Fe-2S] cluster insertion into a subset of cytosolic proteins (PubMed:26613676, PubMed:27519415). Acts as a critical negative regulator of cardiac hypertrophy and a positive inotropic regulator (). Required for hemoglobin maturation (PubMed:23615448). Does not possess any thyoredoxin activity since it lacks the conserved motif that is essential for catalytic activity.
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Product References and Citations for GLRX3 recombinant protein

   Witte S., et al. (2000) J Biol Chem 275 (3): 1902-9.; Haunhorst P., et al. (2010) Biochem Biophys Res Commun. 394 (2):372-6;
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 Research Articles on GLRX3    1. GLRX3 might be an oncoprotein in nasopharyngeal carcinoma
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with GLRX3 recombinant proteinDiseases associated with GLRX3 recombinant protein
 Reference Product  PubMed Publications
 CIAPIN1 recombinant protein  >3 publications with GLRX3 and CIAPIN1
 GLRX2 recombinant protein  >1 publications with GLRX3 and GLRX2
 GLRX recombinant protein  >1 publications with GLRX3 and GLRX
 Disease Name  Pubmed Publications
 Neoplasm Metastasis Antibodies  >3 publications with GLRX3 and Neoplasm Metastasis
 Liver Diseases Antibodies  >3 publications with GLRX3 and Liver Diseases
 Hypertrophy Antibodies  >3 publications with GLRX3 and Hypertrophy
 Liver Neoplasms Antibodies  >2 publications with GLRX3 and Liver Neoplasms
 Lung Neoplasms Antibodies  >2 publications with GLRX3 and Lung Neoplasms
 Cardiovascular Diseases Antibodies  >1 publications with GLRX3 and Cardiovascular Diseases
 Carcinoma, Hepatocellular Antibodies  >1 publications with GLRX3 and Carcinoma, Hepatocellular
 Heart Diseases Antibodies  >1 publications with GLRX3 and Heart Diseases
 Necrosis Antibodies  >1 publications with GLRX3 and Necrosis
 Abnormalities, Drug-Induced Antibodies  >1 publications with GLRX3 and Abnormalities, Drug-Induced
Organs/Tissues associated with GLRX3 recombinant protein
 Organ/Tissue Name  Pubmed Publications
 Liver Antibodies  >4 publications with GLRX3 and Liver
 Blood Antibodies  >4 publications with GLRX3 and Blood
 Lung Antibodies  >3 publications with GLRX3 and Lung
 Brain Antibodies  >3 publications with GLRX3 and Brain
 Kidney Antibodies  >2 publications with GLRX3 and Kidney
 Vascular Antibodies  >2 publications with GLRX3 and Vascular
 Prostate Antibodies  >2 publications with GLRX3 and Prostate
 Pancreas Antibodies  >1 publications with GLRX3 and Pancreas
 Lymph Antibodies  >1 publications with GLRX3 and Lymph
 Bladder Antibodies  >1 publications with GLRX3 and Bladder
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