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Add To Compare List mGSTM1 active protein :: Glutathione S-Transferase M1 Active Protein Catalog # MBS143631 Unit / Price 0.01 mg / $245 +1 FREE 8GB USB 0.05 mg / $320 +1 FREE 8GB USB 1 mg / $1,975 +2 FREE 8GB USB 5x1 mg / $8,555 +10 FREE 8GB USB Product Name Product Info Accession #s Product Desc Diseases/Tissues/Pathways Applications References Product Name Glutathione S-Transferase M1 (mGSTM1), Active Protein Popular Item Full Product Name Recombinant Mouse Glutathione S-Transferase M1 Product Synonym Names GSTM1 Mouse; Glutathione S-Transferase M1 Mouse Recombinant; GST1; GTH4; GTM1; GSTM1-1; MGC26563; GSTM1a-1a; GSTM1b-1b; GSTM1; Glutathione S-transferase Mu 1; GST class-mu 1; Glutathione S-transferase GT8.7; pmGT10; GST 1-1 Product Gene Name mGSTM1 active protein[Similar Products] Research Use Only For Research Use Only. Not for use in diagnostic procedures. TOP Sequence MPMILGYWNV RGLTHPIRML LEYTDSSYDE KRYTMGDAPD FDRSQWLNEK FKLGLDFPNL PYLIDGSHKI TQSNAILRYL ARKHHLDGET EEERIRADIV ENQVMDTRMQ LIMLCYNPDF EKQKPEFLKT IPEKMKLYSE FLGKRPWFAG DKVTYVDFLA YDILDQYRMF EPKCLDAFPN LRDFLARFEG LKKISAYMKS SRYIATPIFS KMAHWSNK 3D Structure ModBase 3D Structure for P10649 Host E Coli Purity/Purification Greater than 95.0% as determined by SDS-PAGE. Form/Format The GSTM1 solution contains PBS pH-7.4 & 5mM glutathione.Sterile Filtered colorless solution. Biological Activity Specific activity is 3 units/mg, and is defined as the amount of enzyme that conjugate 1.0 u mole of 1-chloro-2,4-dinitrobenzene (CDNB) with reduced glutathione per minute at pH 6.5 at 25 degree C. Preparation and Storage Store at 4 degree C if entire vial will be used within 2-4 weeks. Store, frozen at -20 degree C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles. Active Protein Note Protein activity can be an ambiguous term. Please refer to the data sheet or inquire with Technical Support to determine the definition of activity for this product. Other Notes Small volumes of mGSTM1 active protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply. TOP Related Product Information for mGSTM1 active protein Description: GSTM1 Mouse Recombinant produced in E Coli is a single, non-glycosylated, polypeptide chain containing 218 amino acids and having a molecular mass of 25.9 kDa.The GTM1 is purified by proprietary chromatographic techniques.Introduction: Cytosolic and membrane-bound types of GST are encoded by 2 different supergene families. There are 8 classes of the soluble cytoplasmic mammalian GST: alpha, kappa, mu, omega, pi, sigma, theta and zeta. The mu class of enzymes functions in the detoxification of electrophilic compounds, including carcinogens, therapeutic drugs, environmental toxins and products of oxidative stress, by conjugation with glutathione. The genes encoding the mu class of enzymes are arranged in a gene cluster on chromosome 1p13.3 and aare highly polymorphic. These genetic differences can change an individual's resistance to carcinogens and toxins as well as affect the toxicity and efficacy of certain drugs. Null mutations of this class mu gene have been linked with the rise in a number of cancers. Product Categories/Family for mGSTM1 active protein Enzymes; Transferase NCBI/Uniprot data below describe general gene information for mGSTM1. It may not necessarily be applicable to this product. NCBI GI # 6754084 NCBI GeneID 14862 NCBI Accession # NP_034488.1 [Other Products] NCBI GenBank Nucleotide # NM_010358.5 [Other Products] UniProt Primary Accession # P10649 [Other Products] UniProt Secondary Accession # Q58ET5; A2AE90[Other Products] UniProt Related Accession # P10649[Other Products] Molecular Weight 25,970 Da TOP NCBI Official Full Name glutathione S-transferase Mu 1 NCBI Official Synonym Full Names glutathione S-transferase, mu 1 NCBI Official Symbol Gstm1 [Similar Products] NCBI Official Synonym Symbols Gstb1; Gstb-1 [Similar Products] NCBI Protein Information glutathione S-transferase Mu 1; GST 1-1; GST class-mu 1; glutathione S-transferase GT8.7; glutathione-S-transferase, mu 1; pmGT10 UniProt Protein Name Glutathione S-transferase Mu 1 UniProt Synonym Protein Names GST 1-1; GST class-mu 1; Glutathione S-transferase GT8.7; pmGT10 UniProt Gene Name Gstm1 [Similar Products] UniProt Entry Name GSTM1_MOUSE TOP TOP UniProt Comments for mGSTM1 GSTM1: Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. Belongs to the GST superfamily. Mu family. 2 isoforms of the human protein are produced by alternative splicing.Protein type: Xenobiotic Metabolism - drug metabolism - cytochrome P450; Xenobiotic Metabolism - metabolism by cytochrome P450; Transferase; Other Amino Acids Metabolism - glutathione; EC 2.5.1.18Cellular Component: protein complex; cytoplasm; extracellular region; myelin sheathMolecular Function: transferase activity; protein binding; protein homodimerization activity; glutathione transferase activity; protein heterodimerization activity; nickel ion binding; steroid bindingBiological Process: glutathione metabolic process; metabolic process Research Articles on mGSTM1 1. Genetic variants that cause a decremental change in expression of Gstm1 may permit an environment of exaggerated oxidative stress, leading to susceptibility to vascular remodeling and atherosclerosis TOP Precautions All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines. Disclaimer While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information. TOP Pathways associated with mGSTM1 active protein Products by Pathway Pathway Diagram Aflatoxin B1 Metabolism Pathway antibodies Aflatoxin B1 Metabolism Pathway Diagram Biological Oxidations Pathway antibodies Biological Oxidations Pathway Diagram Chemical Carcinogenesis Pathway antibodies Chemical Carcinogenesis Pathway Diagram Chemical Carcinogenesis Pathway antibodies Chemical Carcinogenesis Pathway Diagram Defective AHCY Causes Hypermethioninemia With S-adenosylhomocysteine Hydrolase Deficiency (HMAHCHD) Pathway antibodies Defective AHCY Causes Hypermethioninemia With S-adenosylhomocysteine Hydrolase Deficiency (HMAHCHD) Pathway Diagram Defective GCLC Causes Hemolytic Anemia Due To Gamma-glutamylcysteine Synthetase Deficiency (HAGGSD) Pathway antibodies Defective GCLC Causes Hemolytic Anemia Due To Gamma-glutamylcysteine Synthetase Deficiency (HAGGSD) Pathway Diagram Defective GGT1 Causes Glutathionuria (GLUTH) Pathway antibodies Defective GGT1 Causes Glutathionuria (GLUTH) Pathway Diagram Defective GSS Causes Glutathione Synthetase Deficiency (GSS Deficiency) Pathway antibodies Defective GSS Causes Glutathione Synthetase Deficiency (GSS Deficiency) Pathway Diagram Defective MAT1A Causes Methionine Adenosyltransferase Deficiency (MATD) Pathway antibodies Defective MAT1A Causes Methionine Adenosyltransferase Deficiency (MATD) Pathway Diagram Defective OPLAH Causes 5-oxoprolinase Deficiency (OPLAHD) Pathway antibodies Defective OPLAH Causes 5-oxoprolinase Deficiency (OPLAHD) Pathway Diagram Diseases associated with mGSTM1 active protein Disease Name Pubmed Publications Disease Susceptibility Antibodies >1260 publications with mGSTM1 and Disease Susceptibility Lung Neoplasms Antibodies >313 publications with mGSTM1 and Lung Neoplasms Carcinoma, Squamous Cell Antibodies >223 publications with mGSTM1 and Carcinoma, Squamous Cell Skin Diseases Antibodies >209 publications with mGSTM1 and Skin Diseases Colorectal Neoplasms Antibodies >150 publications with mGSTM1 and Colorectal Neoplasms Leukemia Antibodies >142 publications with mGSTM1 and Leukemia Liver Diseases Antibodies >135 publications with mGSTM1 and Liver Diseases Urinary Bladder Neoplasms Antibodies >130 publications with mGSTM1 and Urinary Bladder Neoplasms Chromosome Aberrations Antibodies >128 publications with mGSTM1 and Chromosome Aberrations Asthma Antibodies >98 publications with mGSTM1 and Asthma Organs/Tissues associated with mGSTM1 active protein Organ/Tissue Name Pubmed Publications Blood Antibodies >849 publications with mGSTM1 and Blood Lung Antibodies >459 publications with mGSTM1 and Lung Liver Antibodies >200 publications with mGSTM1 and Liver Bladder Antibodies >175 publications with mGSTM1 and Bladder Stomach Antibodies >91 publications with mGSTM1 and Stomach Prostate Antibodies >83 publications with mGSTM1 and Prostate Skin Antibodies >76 publications with mGSTM1 and Skin Kidney Antibodies >64 publications with mGSTM1 and Kidney Brain Antibodies >56 publications with mGSTM1 and Brain Heart Antibodies >47 publications with mGSTM1 and Heart TOP © 2006-24 MyBioSource.com. 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