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GSTT1 recombinant protein :: Glutathione S Transferase, T1-1 Human Recombinant Protein

Scan QR to view Datasheet Catalog #    MBS635557 GSTT1 recombinant protein
Unit / Price
0.1 mg  /  $555 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Glutathione S Transferase, T1-1 Human (GSTT1), Recombinant Protein

★Popular Item★
 Also Known As   

Glutathione S Transferase, T1-1, Recombinant Human (GST)

 Product Gene Name   

GSTT1 recombinant protein

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Chromosome Location    Chromosome: 22; NC_000022.10 (24376135..24384284, complement). Location: 22q11.23
 OMIM    600436
 3D Structure    ModBase 3D Structure for P30711
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 Specificity    This purified product exhibits high enzymatic activity for CDNB, the synthetic substrate that is most commonly used for GST analyses. However, as is widely known for GST activity analysis using. CDNB as a substrate, low concentrations (high dilutions) of the enzyme result in lower activity values.
 Purity/Purification    ~95% (SDS-PAGE)
Specifications: >95%
 Form/Format    Supplied as a liquid in 50mM Tris-HCl, pH 7.5, 50mM sodium chloride, 1mM DTT, 5mM EDTA and 50% glycerol.
 Concentration    ~1mg/ml
Specifications: 2.5mg/ml (lot specific)
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 Biological Activity    ~30 Units/mg using spectrophotometric determination of 4- nitrobenzyl chloride conjugation with reduced glutathione (5mM) in 100mM NaPO4 (pH 6.5) at room temperature.
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 Preparation and Storage    May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
 Other Notes    Small volumes of GSTT1 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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 Product Categories/Family for GSTT1 recombinant protein    BioSeparation; BioSep-Assay Detection, Tags
NCBI/Uniprot data below describe general gene information for GSTT1. It may not necessarily be applicable to this product.
 NCBI GI #    167466164
 NCBI GeneID    2952
 NCBI Accession #    NP_000844.2 [Other Products]
 NCBI GenBank Nucleotide #    NM_000853.2 [Other Products]
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 UniProt Primary Accession #    P30711 [Other Products]
 UniProt Secondary Accession #    O00226; Q5TZY2; Q969K8; Q96IY3 [Other Products]
 UniProt Related Accession #    P30711 [Other Products]
 Molecular Weight    ~25kD [Similar Products]
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 NCBI Official Full Name    glutathione S-transferase theta-1
 NCBI Official Synonym Full Names    glutathione S-transferase theta 1
 NCBI Official Symbol    GSTT1 [Similar Products]
 NCBI Protein Information    glutathione S-transferase theta-1; GST class-theta-1; glutathione transferase T1-1
 UniProt Protein Name    Glutathione S-transferase theta-1
 UniProt Synonym Protein Names   
GST class-theta-1; Glutathione transferase T1-1
 Protein Family    Glutathione S-transferase
 UniProt Gene Name    GSTT1 [Similar Products]
 UniProt Entry Name    GSTT1_HUMAN
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 NCBI Summary for GSTT1    Glutathione S-transferase (GST) theta 1 (GSTT1) is a member of a superfamily of proteins that catalyze the conjugation of reduced glutathione to a variety of electrophilic and hydrophobic compounds. Human GSTs can be divided into five main classes: alpha, mu, pi, theta, and zeta. The theta class includes GSTT1 and GSTT2. The GSTT1 and GSTT2 share 55% amino acid sequence identity and both of them were claimed to have an important role in human carcinogenesis. The GSTT1 gene is located approximately 50kb away from the GSTT2 gene. The GSTT1 and GSTT2 genes have a similar structure, being composed of five exons with identical exon/intron boundaries. [provided by RefSeq, Jul 2008]
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 UniProt Comments for GSTT1    GSTT1: Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. Acts on 1,2- epoxy-3-(4-nitrophenoxy)propane, phenethylisothiocyanate 4- nitrobenzyl chloride and 4-nitrophenethyl bromide. Displays glutathione peroxidase activity with cumene hydroperoxide. Belongs to the GST superfamily. Theta family.

Protein type: Transferase; Xenobiotic Metabolism - drug metabolism - cytochrome P450; EC 2.5.1.18; Xenobiotic Metabolism - metabolism by cytochrome P450; Other Amino Acids Metabolism - glutathione

Chromosomal Location of Human Ortholog: 22q11.23

Cellular Component: cytosol

Molecular Function: glutathione transferase activity; glutathione peroxidase activity

Biological Process: glutathione metabolic process; xenobiotic metabolic process
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 Research Articles on GSTT1    1. The NULL genotype for GSTT1 increases the risk of schizophrenia in a sample of an Iranian population.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with GSTT1 recombinant proteinPathways associated with GSTT1 recombinant protein
 Reference Product  PubMed Publications
 GSTM1 recombinant protein  >1873 publications with GSTT1 and GSTM1
 GSTP1 recombinant protein  >832 publications with GSTT1 and GSTP1
 CYP1A1 recombinant protein  >398 publications with GSTT1 and CYP1A1
 GSTA1 recombinant protein  >84 publications with GSTT1 and GSTA1
 GSTA4 recombinant protein  >6 publications with GSTT1 and GSTA4
 GSTA2 recombinant protein  >6 publications with GSTT1 and GSTA2
 GSTA3 recombinant protein  >4 publications with GSTT1 and GSTA3
 ATM recombinant protein  >2 publications with GSTT1 and ATM
 Products by Pathway  Pathway Diagram
 Aflatoxin B1 Metabolism Pathway antibodies  Aflatoxin B1 Metabolism Pathway Diagram
 Biological Oxidations Pathway antibodies  Biological Oxidations Pathway Diagram
 Chemical Carcinogenesis Pathway antibodies  Chemical Carcinogenesis Pathway Diagram
 Chemical Carcinogenesis Pathway antibodies  Chemical Carcinogenesis Pathway Diagram
 Drug Metabolism - Cytochrome P450 Pathway antibodies  Drug Metabolism - Cytochrome P450 Pathway Diagram
 Drug Metabolism - Cytochrome P450 Pathway antibodies  Drug Metabolism - Cytochrome P450 Pathway Diagram
 Glutathione Conjugation Pathway antibodies  Glutathione Conjugation Pathway Diagram
 Glutathione Metabolism Pathway antibodies  Glutathione Metabolism Pathway Diagram
 Glutathione Metabolism Pathway antibodies  Glutathione Metabolism Pathway Diagram
 Glutathione Metabolism Pathway antibodies  Glutathione Metabolism Pathway Diagram
Diseases associated with GSTT1 recombinant protein
 Disease Name  Pubmed Publications
 Neoplasms Antibodies  >988 publications with GSTT1 and Neoplasms
 Carcinoma Antibodies  >326 publications with GSTT1 and Carcinoma
 Lung Diseases Antibodies  >207 publications with GSTT1 and Lung Diseases
 Gastrointestinal Diseases Antibodies  >194 publications with GSTT1 and Gastrointestinal Diseases
 Lung Neoplasms Antibodies  >136 publications with GSTT1 and Lung Neoplasms
 Breast Neoplasms Antibodies  >102 publications with GSTT1 and Breast Neoplasms
 Chromosome Aberrations Antibodies  >101 publications with GSTT1 and Chromosome Aberrations
 Nervous System Diseases Antibodies  >97 publications with GSTT1 and Nervous System Diseases
 Liver Diseases Antibodies  >95 publications with GSTT1 and Liver Diseases
 Urinary Bladder Neoplasms Antibodies  >76 publications with GSTT1 and Urinary Bladder Neoplasms
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