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GSTP1 recombinant protein :: Glutathione S-Transferase pi 1 Recombinant Protein

Scan QR to view Datasheet Catalog #    MBS143603 GSTP1 recombinant protein
Unit / Price
0.005 mg  /  $140 +1 FREE 8GB USB
0.02 mg  /  $205 +1 FREE 8GB USB
1 mg  /  $3,515 +4 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Glutathione S-Transferase pi 1 (GSTP1), Recombinant Protein

 Also Known As   

Recombinant Human Glutathione S-Transferase pi 1

 Product Synonym Names    GSTP1 Human; Glutathione S-Transferase pi 1 Human Recombinant; Glutathione S-transferase P; GST class-pi; GSTP1-1; GSTP1; FAEES3; GST3; PI; DFN7
 Product Gene Name   

GSTP1 recombinant protein

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Sequence    MRGSHHHHHH GMASMTGGQQ MGRDLYDDDD KDRWGSHMPP YTVVYFPVRG RCAALRMLLA DQGQSWKEEV VTVETWQEGS LKASCLYGQL PKFQDGDLTL YQSNTILRHL GRTLGLYGKD QQEAALVDMV NDGVEDLRCK YISLIYTNYE AGKDDYVKAL PGQLKPFETL LSQNQGGKTF IVGDQISFAD YNLLDLLLIH EVLAPGCLDA FPLLSAYVGR LSARPKLKAF LASPEYVNLP INGNGKQ.
 OMIM    134660
 3D Structure    ModBase 3D Structure for P09211
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 Host    E Coli
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 Purity/Purification    Greater than 95.0% as determined by SDS-PAGE.
 Form/Format    The GSTP1 solution contains 20mM Tris-HCl buffer (pH7.0), 30% glycerol, 1mM EDTA and 0.1mM PMSF.
Sterile Filtered colorless solution.
 Concentration    20ug/40ul (lot specific)
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 Biological Activity    Specific activity is < 6.5 units/mg, and is defined as the amount of enzyme that conjugate 1.0 u mole of 1-chloro-2,4-dinitrobenzene (CDNB) with reduced glutathione per minute at pH 6.5 at 25C.
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 Other Notes    Small volumes of GSTP1 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Product Description specifically for GSTP1 recombinant protein

   Description: GSTP1 Human Recombinant fused with 37 amino acid His tag at N-terminus produced in E Coli is a single, non-glycosylated, polypeptide chain containing 247 amino acids (1-210 a.a.) and having a molecular mass of 27.6kDa.The GSTP1 is purified by proprietary chromatographic techniques.

Introduction: GSTP1 is a polymorphic gene encoding active, functionally different GSTP1 variant proteins that are believed to function in xenobiotic metabolism and have a part in susceptibility to cancer, and other diseases. GSTP1 is a glutathione S-transferase belonging to the pi class. GST family enzymes play a significant role in detoxification by catalyzing the conjugation of many hydrophobic and electrophilic compounds with reduced glutathione. Based upon the biochemical, immunologic and structural properties of the soluble GSTs they are grouped into 4 main classes: alpha, mu, pi, and theta. The GSTP1 enzyme acts by catalyzing the reaction of glutathione with an acceptor molecule to form a Sulfur-substituted glutathione. The reactions employing glutathione contribute the transformation of a broad range of electrophiles, including reactive products of lipid, protein, carcinogens, therapeutic drugs, environmental toxins, and products of oxidative stress.The GSTP1 inactivation through CpG hypermethylation is frequent in pituitary adenomas and may be a factor in aggressive pituitary tumor behavior. GSTP1 is may be a transcriptional target of the p53 tumor suppressor gene. Single-nucleotide polymorphism in GSTP1 is linked to modified protein binding, which influence GSTP1's contribution to carcinogen and drug metabolism, and possibly disease pathogenesis and/or drug response. GST-pi might have central roles in proliferation of androgen-independent human prostate cancer cells.
 Product Categories/Family for GSTP1 recombinant protein    ENZYMES; Enzymes; Transferase
NCBI/Uniprot data below describe general gene information for GSTP1. It may not necessarily be applicable to this product.
 NCBI GI #    4504183
 NCBI GeneID    2950
 NCBI Accession #    NP_000843.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_000852.3 [Other Products]
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 UniProt Primary Accession #    P09211 [Other Products]
 UniProt Secondary Accession #    O00460; Q15690; Q5TZY3 [Other Products]
 UniProt Related Accession #    P09211 [Other Products]
 Molecular Weight    23,356 Da
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 NCBI Official Full Name    glutathione S-transferase P
 NCBI Official Synonym Full Names    glutathione S-transferase pi 1
 NCBI Official Symbol    GSTP1 [Similar Products]
 NCBI Official Synonym Symbols   
PI; DFN7; GST3; GSTP; FAEES3; HEL-S-22
[Similar Products]
 NCBI Protein Information    glutathione S-transferase P; GST class-pi; GSTP1-1; deafness, X-linked 7; epididymis secretory protein Li 22; fatty acid ethyl ester synthase III
 UniProt Protein Name    Glutathione S-transferase P
 UniProt Synonym Protein Names   
GST class-pi; GSTP1-1
 Protein Family    Glutathione S-transferase
 UniProt Gene Name    GSTP1 [Similar Products]
 UniProt Synonym Gene Names    FAEES3; GST3 [Similar Products]
 UniProt Entry Name    GSTP1_HUMAN
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 NCBI Summary for GSTP1    Glutathione S-transferases (GSTs) are a family of enzymes that play an important role in detoxification by catalyzing the conjugation of many hydrophobic and electrophilic compounds with reduced glutathione. Based on their biochemical, immunologic, and structural properties, the soluble GSTs are categorized into 4 main classes: alpha, mu, pi, and theta. This GST family member is a polymorphic gene encoding active, functionally different GSTP1 variant proteins that are thought to function in xenobiotic metabolism and play a role in susceptibility to cancer, and other diseases. [provided by RefSeq, Jul 2008]
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 UniProt Comments for GSTP1    GSTP1: Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. Regulates negatively CDK5 activity via p25/p35 translocation to prevent neurodegeneration. Homodimer. Interacts with CDK5. Belongs to the GST superfamily. Pi family.

Protein type: Transferase; EC 2.5.1.18; Other Amino Acids Metabolism - glutathione; Xenobiotic Metabolism - metabolism by cytochrome P450; Xenobiotic Metabolism - drug metabolism - cytochrome P450

Chromosomal Location of Human Ortholog: 11q13

Cellular Component: extracellular space; mitochondrion; cytoplasm; plasma membrane; intracellular; nucleus; cytosol; vesicle

Molecular Function: JUN kinase binding; protein binding; glutathione transferase activity; kinase regulator activity

Biological Process: negative regulation of MAP kinase activity; negative regulation of JNK activity; central nervous system development; negative regulation of MAPKKK cascade; negative regulation of acute inflammatory response; negative regulation of interleukin-1 beta production; negative regulation of I-kappaB kinase/NF-kappaB cascade; negative regulation of tumor necrosis factor production; negative regulation of stress-activated MAPK cascade; regulation of stress-activated MAPK cascade; negative regulation of biosynthetic process; response to reactive oxygen species; glutathione metabolic process; negative regulation of nitric-oxide synthase biosynthetic process; negative regulation of fibroblast proliferation; xenobiotic metabolic process; positive regulation of superoxide release; negative regulation of protein kinase activity; negative regulation of apoptosis
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 Research Articles on GSTP1    1. In breast cancer cells, GSTP1 inhibits the expression of RIP140, a negative regulator of estrogen receptor alpha transcription, at both mRNA and protein levels.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with GSTP1 recombinant proteinPathways associated with GSTP1 recombinant protein
 Reference Product  PubMed Publications
 CYP1A1 recombinant protein  >280 publications with GSTP1 and CYP1A1
 CYP2E1 recombinant protein  >149 publications with GSTP1 and CYP2E1
 EPHX1 recombinant protein  >140 publications with GSTP1 and EPHX1
 CYP1B1 recombinant protein  >91 publications with GSTP1 and CYP1B1
 CYP3A4 recombinant protein  >72 publications with GSTP1 and CYP3A4
 GPX1 recombinant protein  >27 publications with GSTP1 and GPX1
 CYP2C19 recombinant protein  >19 publications with GSTP1 and CYP2C19
 GSTZ1 recombinant protein  >17 publications with GSTP1 and GSTZ1
 MAPK8 recombinant protein  >4 publications with GSTP1 and MAPK8
 Products by Pathway  Pathway Diagram
 4-hydroxy-2-nonenal Detoxification Pathway antibodies  4-hydroxy-2-nonenal Detoxification Pathway Diagram
 Arachidonate Epoxygenase / Epoxide Hydrolase Pathway antibodies  Arachidonate Epoxygenase / Epoxide Hydrolase Pathway Diagram
 Biological Oxidations Pathway antibodies  Biological Oxidations Pathway Diagram
 Cellular Responses To Stress Pathway antibodies  Cellular Responses To Stress Pathway Diagram
 Chemical Carcinogenesis Pathway antibodies  Chemical Carcinogenesis Pathway Diagram
 Chemical Carcinogenesis Pathway antibodies  Chemical Carcinogenesis Pathway Diagram
 Defective AHCY Causes Hypermethioninemia With S-adenosylhomocysteine Hydrolase Deficiency (HMAHCHD) Pathway antibodies  Defective AHCY Causes Hypermethioninemia With S-adenosylhomocysteine Hydrolase Deficiency (HMAHCHD) Pathway Diagram
 Defective GCLC Causes Hemolytic Anemia Due To Gamma-glutamylcysteine Synthetase Deficiency (HAGGSD) Pathway antibodies  Defective GCLC Causes Hemolytic Anemia Due To Gamma-glutamylcysteine Synthetase Deficiency (HAGGSD) Pathway Diagram
 Defective GGT1 Causes Glutathionuria (GLUTH) Pathway antibodies  Defective GGT1 Causes Glutathionuria (GLUTH) Pathway Diagram
 Defective GSS Causes Glutathione Synthetase Deficiency (GSS Deficiency) Pathway antibodies  Defective GSS Causes Glutathione Synthetase Deficiency (GSS Deficiency) Pathway Diagram
Diseases associated with GSTP1 recombinant proteinOrgans/Tissues associated with GSTP1 recombinant protein
 Disease Name  Pubmed Publications
 Carcinoma Antibodies  >928 publications with GSTP1 and Carcinoma
 Prostatic Neoplasms Antibodies  >330 publications with GSTP1 and Prostatic Neoplasms
 Liver Diseases Antibodies  >292 publications with GSTP1 and Liver Diseases
 Lung Neoplasms Antibodies  >292 publications with GSTP1 and Lung Neoplasms
 Liver Neoplasms Antibodies  >254 publications with GSTP1 and Liver Neoplasms
 Neoplasms, Experimental Antibodies  >237 publications with GSTP1 and Neoplasms, Experimental
 Nervous System Diseases Antibodies  >189 publications with GSTP1 and Nervous System Diseases
 Disease Progression Antibodies  >180 publications with GSTP1 and Disease Progression
 Stomach Neoplasms Antibodies  >140 publications with GSTP1 and Stomach Neoplasms
 Carcinoma, Hepatocellular Antibodies  >123 publications with GSTP1 and Carcinoma, Hepatocellular
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >739 publications with GSTP1 and Blood
 Liver Antibodies  >697 publications with GSTP1 and Liver
 Lung Antibodies  >514 publications with GSTP1 and Lung
 Prostate Antibodies  >364 publications with GSTP1 and Prostate
 Kidney Antibodies  >198 publications with GSTP1 and Kidney
 Brain Antibodies  >193 publications with GSTP1 and Brain
 Stomach Antibodies  >160 publications with GSTP1 and Stomach
 Bladder Antibodies  >120 publications with GSTP1 and Bladder
 Skin Antibodies  >105 publications with GSTP1 and Skin
 Placenta Antibodies  >94 publications with GSTP1 and Placenta
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