NP_038569.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
25.5 kDa
NCBI Official Full Name
glutathione S-transferase P 1
NCBI Official Synonym Full Names
glutathione S-transferase, pi 1
NCBI Official Synonym Symbols
NCBI Protein Information
glutathione S-transferase P 1
UniProt Protein Name
Glutathione S-transferase P 1
UniProt Synonym Protein Names
GST YF-YF; GST class-pi; GST-piB; Preadipocyte growth factor
UniProt Synonym Gene Names
UniProt Entry Name
GSTP1_MOUSE
UniProt Comments for Gstp1
GSTP1: Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. Regulates negatively CDK5 activity via p25/p35 translocation to prevent neurodegeneration. Homodimer. Interacts with CDK5. Belongs to the GST superfamily. Pi family.
Protein type: Transferase; Xenobiotic Metabolism - drug metabolism - cytochrome P450; Xenobiotic Metabolism - metabolism by cytochrome P450; EC 2.5.1.18; Other Amino Acids Metabolism - glutathione
Cellular Component: cytoplasm; cytosol; extracellular space; intracellular; mitochondrion; nucleus; plasma membrane; protein complex; vesicle
Molecular Function: drug binding; glutathione binding; glutathione transferase activity; JUN kinase binding; kinase regulator activity; protein binding; protein kinase binding; transferase activity
Biological Process: glutathione metabolic process; metabolic process; negative regulation of acute inflammatory response; negative regulation of apoptosis; negative regulation of biosynthetic process; negative regulation of fibroblast proliferation; negative regulation of I-kappaB kinase/NF-kappaB cascade; negative regulation of interleukin-1 beta production; negative regulation of JNK activity; negative regulation of nitric-oxide synthase biosynthetic process; negative regulation of stress-activated MAPK cascade; negative regulation of tumor necrosis factor production; positive regulation of superoxide release; regulation of stress-activated MAPK cascade; response to reactive oxygen species
Product References and Citations for Gstp1 recombinant protein
A cDNA sequence coding a class pi glutathione S-transferase of mouse.Hatayama I., Satoh K., Sato K.Nucleic Acids Res. 18:4606-4606(1990)
Isolation and characterization of two mouse PI class glutathione S-transferase genes.Bammler T.K., Smith C.A.D., Wolf R.C.Biochem. J. 298:385-390(1994)
Two murine GSTpi genes are arranged in tandem and are differentially expressed.Xu X., Stambrook P.J.J. Biol. Chem. 269:30268-30273(1994)
Molecular cloning of mouse preadipocyte growth factor.Kawada T., Aoki N., Kamei Y., Sugimoto E.
Lubec G., Klug S., Kang S.U.Submitted (APR-2007)
to UniProtKB
Purification, mass spectrometric characterization, and covalent modification of murine glutathione S-transferases.Mitchell A.E., Morin D., Lame M.W., Jones A.D.Chem. Res. Toxicol. 8:1054-1062(1995)
SIRT5-mediated lysine desuccinylation impacts diverse metabolic pathways.Park J., Chen Y., Tishkoff D.X., Peng C., Tan M., Dai L., Xie Z., Zhang Y., Zwaans B.M., Skinner M.E., Lombard D.B., Zhao Y.Mol. Cell 50:919-930(2013)
Molecular structure at 1.8 A of mouse liver class pi glutathione S-transferase complexed with S-(p-nitrobenzyl)
glutathione and other inhibitors.Garcia-Saez I., Parraga A., Phillips M.F., Mantle T.J., Coll M.J. Mol. Biol. 237:298-314(1994)
The three-dimensional structure of Cys-47-modified mouse liver glutathione S-transferase P1-1. Carboxymethylation dramatically decreases the affinity for glutathione and is associated with a loss of electron density in the alphaB-310B region.Vega M.C., Walsh S.B., Mantle T.J., Coll M.J. Biol. Chem. 273:2844-2850(1998)
Research Articles on Gstp1
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Products associated with Gstp1 recombinant protein
Pathways associated with Gstp1 recombinant protein
Diseases associated with Gstp1 recombinant protein
Organs/Tissues associated with Gstp1 recombinant protein
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