NP_001305794.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
32,742 Da
NCBI Official Full Name
glycine N-methyltransferase isoform 2
NCBI Official Synonym Full Names
glycine N-methyltransferase
NCBI Official Synonym Symbols
NCBI Protein Information
glycine N-methyltransferase
UniProt Protein Name
Glycine N-methyltransferase
NCBI Summary for GNMT
The protein encoded by this gene is an enzyme that catalyzes the conversion of S-adenosyl-L-methionine (along with glycine) to S-adenosyl-L-homocysteine and sarcosine. This protein is found in the cytoplasm and acts as a homotetramer. Defects in this gene are a cause of GNMT deficiency (hypermethioninemia). Alternative splicing results in multiple transcript variants. Naturally occurring readthrough transcription occurs between the upstream CNPY3 (canopy FGF signaling regulator 3) gene and this gene and is represented with GeneID:107080644. [provided by RefSeq, Jan 2016]
UniProt Comments for GNMT
Catalyzes the methylation of glycine by using S-adenosylmethionine (AdoMet) to form N-methylglycine (sarcosine) with the concomitant production of S-adenosylhomocysteine (AdoHcy). Possible crucial role in the regulation of tissue concentration of AdoMet and of metabolism of methionine.
Research Articles on GNMT
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Products associated with GNMT recombinant protein
Pathways associated with GNMT recombinant protein
Diseases associated with GNMT recombinant protein
Organs/Tissues associated with GNMT recombinant protein
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