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GSK3B recombinant protein :: Glycogen synthase kinase-3 beta Recombinant Protein

Scan QR to view Datasheet Catalog #    MBS142814 GSK3B recombinant protein
Unit / Price
0.002 mg  /  $140 +1 FREE 8GB USB
0.01 mg  /  $205 +1 FREE 8GB USB
1 mg  /  $5,015 +6 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Glycogen synthase kinase-3 beta (GSK3B), Recombinant Protein

★Popular Item★
 Also Known As   

Recombinant Human Glycogen synthase kinase-3 beta

 Product Gene Name   

GSK3B recombinant protein

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Sequence    MSGRPRTTSF AESCKPVQQP SAFGSMKVSR DKDGSKVTTV VATPGQGPDR PQEVSYTDTK VIGNGSFGVV YQAKLCDSGE LVAIKKVLQD KRFKNRELQI MRKLDHCNIV RLRYFFYSSG EKKDEVYLNL VLDYVPETVY RVARHYSRAK QTLPVIYVKL YMYQLFRSLA YIHSFGICHR DIKPQNLLLD PDTAVLKLCD FGSAKQLVRG EPNVSYICSR YYRAPELIFG ATDYTSSIDV WSAGCVLAEL LLGQPIFPGD SGVDQLVEII KVLGTPTREQ IREMNPNYTE FKFPQIKAHP WTKVFRPRTP PEAIALCSRL LEYTPTARLT PLEACAHSFF DELRDPNVKL PNGRDTPALF NFTTQELSSN PPLATILIPP HARIQAAAST PTNATAASDA NTGDRGQTNN AASASASNST
 OMIM    176980
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 Form/Format    PKC-g is supplied at a of 0.1mg/ml in 10mM Tris, pH 7.4, 0.1M NaCl, 20% glycerol, 1mM DTT, 0.1mM EDTA, 0.2mM PMSF and 0.03% Brij-35.
Physical Appearance: Sterile Filtered clear solution.
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 Other Notes    Small volumes of GSK3B recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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 Product Categories/Family for GSK3B recombinant protein    PROTEIN KINASES
NCBI/Uniprot data below describe general gene information for GSK3B. It may not necessarily be applicable to this product.
 NCBI GI #    13384594
 NCBI GeneID    5582
 NCBI Accession #    NP_002730.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_002739.3 [Other Products]
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 UniProt Secondary Accession #    B7Z8Q0 [Other Products]
 UniProt Related Accession #    P05129 [Other Products]
 Molecular Weight    62,030 Da
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 NCBI Official Full Name    protein kinase C gamma type
 NCBI Official Synonym Full Names    protein kinase C, gamma
 NCBI Official Symbol    PRKCG [Similar Products]
 NCBI Official Synonym Symbols   
PKCC; PKCG; SCA14; PKC-gamma
[Similar Products]
 NCBI Protein Information    protein kinase C gamma type
 UniProt Protein Name    Protein kinase C gamma type
 Protein Family    Glycogen synthase kinase
 UniProt Gene Name    PRKCG [Similar Products]
 UniProt Synonym Gene Names    PKCG; PKC-gamma [Similar Products]
 UniProt Entry Name    KPCG_HUMAN
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 NCBI Summary for GSK3B    Protein kinase C (PKC) is a family of serine- and threonine-specific protein kinases that can be activated by calcium and second messenger diacylglycerol. PKC family members phosphorylate a wide variety of protein targets and are known to be involved in diverse cellular signaling pathways. PKC also serve as major receptors for phorbol esters, a class of tumor promoters. Each member of the PKC family has a specific expression profile and is believed to play distinct roles in cells. The protein encoded by this gene is one of the PKC family members. This protein kinase is expressed solely in the brain and spinal cord and its localization is restricted to neurons. It has been demonstrated that several neuronal functions, including long term potentiation (LTP) and long term depression (LTD), specifically require this kinase. Knockout studies in mice also suggest that this kinase may be involved in neuropathic pain development. Defects in this protein have been associated with neurodegenerative disorder spinocerebellar ataxia-14 (SCA14). [provided by RefSeq, Jul 2008]
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 UniProt Comments for GSK3B    PKCG: a calcium-activated, phospholipid- and diacylglycerol (DAG)-dependent serine/threonine-protein kinase. Expressed in the brain and spinal cord where its localization is restricted to neurons. Several neuronal functions, including long term potentiation and depression (LTP&LTD) specifically require this kinase. Knockout studies in mice also suggest that this kinase may be involved in neuropathic pain development. Defects have been associated with neurodegenerative disorder spinocerebellar ataxia-14. Plays diverse roles in neuronal cells and eye tissues, such as regulation of the neuronal receptors GLUR4 and NMDAR1, modulation of receptors and neuronal functions related to sensitivity to opiates, pain and alcohol, mediation of synaptic function and cell survival after ischemia, and inhibition of gap junction activity after oxidative stress. Binds and phosphorylates GLUR4 glutamate receptor and regulates its function by increasing plasma membrane-associated GRIA4 expression. In primary cerebellar neurons treated with the agonist 3,5-dihyidroxyphenylglycine, functions downstream of the metabotropic glutamate receptor MGLUR5 and phosphorylates NMDAR1 receptor which plays a key role in synaptic plasticity, synaptogenesis, excitotoxicity, memory acquisition and learning. May be involved in the regulation of hippocampal long-term potentiation (LTP), but may be not necessary for the process of synaptic plasticity. May modulate the functionality of mu-type-opioid receptors by participating in a signaling pathway which leads to the phosphorylation and degradation of opioid receptors. May also contributes to chronic morphine-induced changes in nociceptive processing. Plays a role in neuropathic pain mechanisms and contributes to the maintenance of the allodynia pain produced by peripheral inflammation. Plays an important role in initial sensitivity and tolerance to ethanol, by mediating the behavioral effects of ethanol as well as the effects of this drug on the GABA(A) receptors. During and after cerebral ischemia modulate neurotransmission and cell survival in synaptic membranes, and is involved in insulin-induced inhibition of necrosis, an important mechanism for minimizing ischemic injury. Required for the elimination of multiple climbing fibers during innervation of Purkinje cells in developing cerebellum. Is activated in lens epithelial cells upon hydrogen peroxide treatment, and phosphorylates connexin-43, resulting in disassembly of GJA1 gap junction plaques and inhibition of gap junction activity which could provide a protective effect against oxidative stress. Phosphorylates p53 and promotes p53-dependent apoptosis in response to DNA damage. Interacts with GRIA4. Interacts with CDCP1. Interacts with TP53INP1 and p53. Expressed in Purkinje cells of the cerebellar cortex.

Protein type: Protein kinase, AGC; EC 2.7.11.13; Protein kinase, Ser/Thr (non-receptor); Kinase, protein; AGC group; PKC family; Alpha subfamily

Chromosomal Location of Human Ortholog: 19q13.4

Cellular Component: perinuclear region of cytoplasm; dendrite; plasma membrane; intercellular junction; nucleus; cytosol

Molecular Function: protein kinase C activity; zinc ion binding; protein serine/threonine/tyrosine kinase activity; calcium-dependent protein kinase C activity; ATP binding; protein kinase activity

Biological Process: epidermal growth factor receptor signaling pathway; platelet activation; positive regulation of mismatch repair; fibroblast growth factor receptor signaling pathway; nerve growth factor receptor signaling pathway; protein amino acid autophosphorylation; rhythmic process; response to morphine; response to pain; regulation of circadian rhythm; signal transduction; protein amino acid phosphorylation; synaptic transmission; learning and/or memory; phospholipase C activation; innate immune response; chemosensory behavior; negative regulation of protein ubiquitination; negative regulation of neuron apoptosis; negative regulation of protein catabolic process; blood coagulation; phosphorylation; regulation of response to food

Disease: Spinocerebellar Ataxia 14
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 Research Articles on GSK3B    1. we show that the mutation V138E of the protein kinase C gamma (PKCgamma) C1B domain, which is implicated in spinocerebellar ataxia type 14, exhibits a partially unfolded C-terminus
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with GSK3B recombinant proteinPathways associated with GSK3B recombinant protein
 Reference Product  PubMed Publications
 PRKCA recombinant protein  >99 publications with GSK3B and PRKCA
 PRKCD recombinant protein  >25 publications with GSK3B and PRKCD
 SRC recombinant protein  >9 publications with GSK3B and SRC
 PRKCB recombinant protein  >2 publications with GSK3B and PRKCB
 HRAS recombinant protein  >1 publications with GSK3B and HRAS
 GRIN2B recombinant protein  >1 publications with GSK3B and GRIN2B
 GJA1 recombinant protein  >1 publications with GSK3B and GJA1
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Diseases associated with GSK3B recombinant proteinOrgans/Tissues associated with GSK3B recombinant protein
 Disease Name  Pubmed Publications
 Nervous System Diseases Antibodies  >172 publications with GSK3B and Nervous System Diseases
 Brain Diseases Antibodies  >89 publications with GSK3B and Brain Diseases
 Pain Antibodies  >86 publications with GSK3B and Pain
 Ataxia Antibodies  >59 publications with GSK3B and Ataxia
 Hyperalgesia Antibodies  >45 publications with GSK3B and Hyperalgesia
 Spinocerebellar Ataxias Antibodies  >38 publications with GSK3B and Spinocerebellar Ataxias
 Cardiovascular Diseases Antibodies  >28 publications with GSK3B and Cardiovascular Diseases
 Mental Disorders Antibodies  >25 publications with GSK3B and Mental Disorders
 Eye Diseases Antibodies  >16 publications with GSK3B and Eye Diseases
 Brain Ischemia Antibodies  >15 publications with GSK3B and Brain Ischemia
 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >241 publications with GSK3B and Brain
 Eye Antibodies  >36 publications with GSK3B and Eye
 Kidney Antibodies  >15 publications with GSK3B and Kidney
 Ovary Antibodies  >4 publications with GSK3B and Ovary
 Stomach Antibodies  >3 publications with GSK3B and Stomach
 Testis Antibodies  >2 publications with GSK3B and Testis
 Thymus Antibodies  >1 publications with GSK3B and Thymus
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