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GARS recombinant protein :: Glycyl tRNA Synthetase Recombinant Protein

Scan QR to view Datasheet Catalog #    MBS2030433 (SPECIAL PROMOTION: Get FREE $5 Starbucks gift card (Maximum 5 gift cards/product). Gift card(s) will be included with shipment)
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Unit / Price
0.01 mg  /  $140 +1 FREE 8GB USB
0.05 mg  /  $260 +1 FREE 8GB USB
0.1 mg  /  $400 +1 FREE 8GB USB
0.2 mg  /  $495 +1 FREE 8GB USB
0.5 mg  /  $955 +1 FREE 8GB USB
1 mg  /  $1,415 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Glycyl tRNA Synthetase (GARS), Recombinant Protein

★Popular Item★
 Also Known As   

Recombinant Glycyl tRNA Synthetase (GARS)

 Product Gene Name   

GARS recombinant protein

[Similar Products]
 Matching Pairs    Antibody: Glycyl tRNA Synthetase (MBS2028384)
Antigen: Glycyl tRNA Synthetase (MBS2030433)
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Sequence    The target protein is fused with two N-terminal Tags, His-tag and T7-tag, its sequence is listed below.
VEEV VPNVIEPSFG LGRIMYTVFE HTFHVREGDE QRTFFSFPAV VAPFKCSVLP LSQNQEFMPF VKELSEALTR HGVSHKVDDS SGSIGRRYAR TDEIGVAFGV TIDFDTVNKT PHTATLRDRD SMRQIRAEIS ELPSIVQDLA NGNITWADVE ARYPLFEGQE TGKKE
 OMIM    600287
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 Host    Host: E Coli
Source: Prokaryotic expression
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 Purity/Purification    >90%
 Form/Format    Supplied as lyophilized form in PBS, pH7.4, containing 5% trehalose, 0.01% sarcosyl.
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 Predicted Molecular Mass    22.7kDa
 Accurate Molecular Mass (KD)    23kDa
 Endotoxin    <1.0EU per 1ug (determined by the LAL method)
 Expression System    Prokaryotic expression
 Tag    two N-terminal Tags, His-tag and S-tag
 Organism Species    Homo sapiens (Human)
 Fragment    Val567~Glu735
 Usage    Reconstitute in sterile PBS, pH7.2-pH7.4.
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 Preparation and Storage    Storage: Avoid repeated freeze/thaw cycles. Store at 2-8 degree C for one month. Aliquot and store at -80 degree C for 12 months.
Stability Test: The thermal stability is described by the loss rate of the targetprotein. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37 degree C for 48h, and no obvious degradation andprecipitation were observed. The loss of this protein is less than 5% within the expiration date under appropriate storage condition.
 ISO Certification    Manufactured in an ISO 9001:2015 and ISO 13485:2016 Certified Laboratory.
 Supply Chain Verification    Manufactured in a lab with traceable raw materials manufactured on site. Coordinated product portfolio of antibodies, pairs, conjugates, recombinant proteins, and immunoassay materials available. Please inquire.
 Other Notes    Small volumes of GARS recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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 Applications Tested/Suitable for GARS recombinant protein   

SDS-PAGE, Western Blot (WB), ELISA (EIA), Immunoprecipitation (IP)

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 SDS-Page of GARS recombinant protein    GARS recombinant protein SDS-Page image
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NCBI/Uniprot data below describe general gene information for GARS. It may not necessarily be applicable to this product.
 NCBI GI #    1311463
 NCBI GeneID    2617
 NCBI Accession #    BAA06338.1 [Other Products]
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 UniProt Secondary Accession #    Q969Y1; B3KQA2; B4DIA0 [Other Products]
 UniProt Related Accession #    P41250 [Other Products]
 Molecular Weight    83,166 Da
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 NCBI Official Full Name    glycyl tRNA synthetase
 NCBI Official Synonym Full Names    glycyl-tRNA synthetase
 NCBI Official Symbol    GARS [Similar Products]
 NCBI Official Synonym Symbols   
HMN5; CMT2D; DSMAV; GlyRS; SMAD1
[Similar Products]
 NCBI Protein Information    glycine--tRNA ligase
 UniProt Protein Name    Glycine--tRNA ligase
 UniProt Synonym Protein Names   
Diadenosine tetraphosphate synthetase; AP-4-A synthetase; Glycyl-tRNA synthetase; GlyRS
 Protein Family    Glycine--tRNA ligase
 UniProt Gene Name    GARS [Similar Products]
 UniProt Synonym Gene Names    AP-4-A synthetase; GlyRS [Similar Products]
 UniProt Entry Name    SYG_HUMAN
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 NCBI Summary for GARS    This gene encodes glycyl-tRNA synthetase, one of the aminoacyl-tRNA synthetases that charge tRNAs with their cognate amino acids. The encoded enzyme is an (alpha)2 dimer which belongs to the class II family of tRNA synthetases. It has been shown to be a target of autoantibodies in the human autoimmune diseases, polymyositis or dermatomyositis. [provided by RefSeq, Jul 2008]
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 UniProt Comments for GARS    GARS: Catalyzes the attachment of glycine to tRNA(Gly). Is also able produce diadenosine tetraphosphate (Ap4A), a universal pleiotropic signaling molecule needed for cell regulation pathways, by direct condensation of 2 ATPs. Defects in GARS are the cause of Charcot-Marie-Tooth disease type 2D (CMT2D). CMT2D is a form of Charcot- Marie-Tooth disease, the most common inherited disorder of the peripheral nervous system. Charcot-Marie-Tooth disease is classified in two main groups on the basis of electrophysiologic properties and histopathology: primary peripheral demyelinating neuropathy or CMT1, and primary peripheral axonal neuropathy or CMT2. Neuropathies of the CMT2 group are characterized by signs of axonal regeneration in the absence of obvious myelin alterations, normal or slightly reduced nerve conduction velocities, and progressive distal muscle weakness and atrophy. CMT2D is characterized by a more severe phenotype in the upper extremities (severe weakness and atrophy, absence of tendon reflexes) than in the lower limbs. CMT2D inheritance is autosomal dominant. Defects in GARS are a cause of distal hereditary motor neuronopathy type 5A (HMN5A); also known as distal hereditary motor neuropathy type V (DSMAV). A disorder characterized by distal muscular atrophy mainly affecting the upper extremities, in contrast to other distal motor neuronopathies. These constitute a heterogeneous group of neuromuscular diseases caused by selective degeneration of motor neurons in the anterior horn of the spinal cord, without sensory deficit in the posterior horn. The overall clinical picture consists of a classical distal muscular atrophy syndrome in the legs without clinical sensory loss. The disease starts with weakness and wasting of distal muscles of the anterior tibial and peroneal compartments of the legs. Later on, weakness and atrophy may expand to the proximal muscles of the lower limbs and/or to the distal upper limbs. Belongs to the class-II aminoacyl-tRNA synthetase family.

Protein type: Ligase; EC 6.1.1.14; Translation; Mitochondrial

Chromosomal Location of Human Ortholog: 7p15

Cellular Component: nucleoplasm; mitochondrial matrix; cytoplasm; cytosol; secretory granule

Molecular Function: protein dimerization activity; glycine-tRNA ligase activity; ATP binding

Biological Process: tRNA aminoacylation for protein translation; glycyl-tRNA aminoacylation; gene expression; diadenosine tetraphosphate biosynthetic process

Disease: Neuronopathy, Distal Hereditary Motor, Type Va; Charcot-marie-tooth Disease, Axonal, Type 2d
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 Research Articles on GARS    1. we propose that the disease-causing L129P mutant of glycyl-tRNA synthetase is linked to a distribution defect in peripheral nerves in vivo.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with GARS recombinant proteinPathways associated with GARS recombinant protein
 Reference Product  PubMed Publications
 AARS recombinant protein  >4 publications with GARS and AARS
 IARS recombinant protein  >1 publications with GARS and IARS
 Products by Pathway  Pathway Diagram
 Aminoacyl-tRNA Biosynthesis Pathway antibodies  Aminoacyl-tRNA Biosynthesis Pathway Diagram
 Aminoacyl-tRNA Biosynthesis Pathway antibodies  Aminoacyl-tRNA Biosynthesis Pathway Diagram
 Aminoacyl-tRNA Biosynthesis, Eukaryotes Pathway antibodies  Aminoacyl-tRNA Biosynthesis, Eukaryotes Pathway Diagram
 Aminoacyl-tRNA Biosynthesis, Eukaryotes Pathway antibodies  Aminoacyl-tRNA Biosynthesis, Eukaryotes Pathway Diagram
 Cytosolic TRNA Aminoacylation Pathway antibodies  Cytosolic TRNA Aminoacylation Pathway Diagram
 Gene Expression Pathway antibodies  Gene Expression Pathway Diagram
 Mitochondrial TRNA Aminoacylation Pathway antibodies  Mitochondrial TRNA Aminoacylation Pathway Diagram
 TRNA Aminoacylation Pathway antibodies  TRNA Aminoacylation Pathway Diagram
Diseases associated with GARS recombinant proteinOrgans/Tissues associated with GARS recombinant protein
 Disease Name  Pubmed Publications
 Nervous System Diseases Antibodies  >140 publications with GARS and Nervous System Diseases
 Cardiovascular Diseases Antibodies  >37 publications with GARS and Cardiovascular Diseases
 Pain Antibodies  >23 publications with GARS and Pain
 Disease Models, Animal Antibodies  >10 publications with GARS and Disease Models, Animal
 Inflammation Antibodies  >5 publications with GARS and Inflammation
 Liver Diseases Antibodies  >4 publications with GARS and Liver Diseases
 Skin Diseases Antibodies  >4 publications with GARS and Skin Diseases
 Cognition Disorders Antibodies  >4 publications with GARS and Cognition Disorders
 Neoplasms, Experimental Antibodies  >4 publications with GARS and Neoplasms, Experimental
 Charcot-Marie-Tooth disease, Type 2D Antibodies  >4 publications with GARS and Charcot-Marie-Tooth disease, Type 2D
 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >76 publications with GARS and Brain
 Bone Antibodies  >45 publications with GARS and Bone
 Nerve Antibodies  >42 publications with GARS and Nerve
 Blood Antibodies  >40 publications with GARS and Blood
 Vascular Antibodies  >35 publications with GARS and Vascular
 Muscle Antibodies  >25 publications with GARS and Muscle
 Eye Antibodies  >11 publications with GARS and Eye
 Ovary Antibodies  >6 publications with GARS and Ovary
 Liver Antibodies  >5 publications with GARS and Liver
 Lung Antibodies  >5 publications with GARS and Lung
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