NP_001257710.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
12,609 Da
NCBI Official Full Name
granzyme H isoform 3
NCBI Official Synonym Full Names
granzyme H
NCBI Official Synonym Symbols
CCP-X; CGL-2; CSP-C; CTLA1; CTSGL2 [Similar Products]
NCBI Protein Information
granzyme H
UniProt Protein Name
Granzyme H
UniProt Synonym Protein Names
CCP-X; Cathepsin G-like 2; CTSGL2; Cytotoxic T-lymphocyte proteinase; Cytotoxic serine protease C; CSP-C
UniProt Synonym Gene Names
NCBI Summary for GZMH
This gene encodes a member of the peptidase S1 family of serine proteases. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed to generate a chymotrypsin-like protease. This protein is reported to be constitutively expressed in the NK (natural killer) cells of the immune system and may play a role in the cytotoxic arm of the innate immune response by inducing target cell death and by directly cleaving substrates in pathogen-infected cells. This gene is present in a gene cluster with another member of the granzyme subfamily on chromosome 14. [provided by RefSeq, Nov 2015]
UniProt Comments for GZMH
Cytotoxic chymotrypsin-like serine protease with preference for bulky and aromatic residues at the P1 position and acidic residues at the P3' and P4' sites. Probably necessary for target cell lysis in cell-mediated immune responses. Participates in the antiviral response via direct cleavage of several proteins essential for viral replication.
Research Articles on GZMH
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Products associated with GZMH recombinant protein
Pathways associated with GZMH recombinant protein
Diseases associated with GZMH recombinant protein
Organs/Tissues associated with GZMH recombinant protein
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