Q63772.1
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UniProt Primary Accession #
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UniProt Related Accession #
Molecular Weight
Predicted Molecular Mass: 24.7kDa Accurate Molecular Mass: 28kDa as determined by SDS-PAGE reducing conditions.
NCBI Official Full Name
Growth arrest-specific protein 6
NCBI Official Synonym Full Names
growth arrest specific 6
NCBI Protein Information
growth arrest-specific protein 6; GPF; GAS-6; growth-potentiating factor; AXL receptor tyrosine kinase ligand
UniProt Protein Name
Growth arrest-specific protein 6
UniProt Synonym Protein Names
AXL receptor tyrosine kinase ligand; Growth-potentiating factor
UniProt Synonym Gene Names
UniProt Entry Name
GAS6_RAT
NCBI Summary for GAS6
provides protection of neurons against serum deprivation-induced apoptosis [RGD, Feb 2006]
UniProt Comments for GAS6
GAS6: Ligand for tyrosine-protein kinase receptors AXL, TYRO3 and MER whose signaling is implicated in cell growth and survival, cell adhesion and cell migration. GAS6/AXL signaling plays a role in various processes such as endothelial cell survival during acidification by preventing apoptosis, optimal cytokine signaling during human natural killer cell development, hepatic regeneration, gonadotropin-releasing hormone neuron survival and migration, platelet activation, or regulation of thrombotic responses. 4 isoforms of the human protein are produced by alternative splicing.
Protein type: Secreted, signal peptide; Ligand, receptor tyrosine kinase; Secreted
Cellular Component: extracellular space; cytoplasm; extracellular region; intracellular
Molecular Function: voltage-gated calcium channel activity; growth factor activity; phosphatidylserine binding; caspase inhibitor activity; protein tyrosine kinase activator activity; calcium ion binding; receptor tyrosine kinase binding; receptor agonist activity; molecular adaptor activity; receptor binding
Biological Process: entry of virus into host cell; tissue remodeling; neuron migration; negative regulation of caspase activity; signal transduction; enzyme linked receptor protein signaling pathway; protein amino acid phosphorylation; positive regulation of protein export from nucleus; positive regulation of natural killer cell differentiation; positive regulation of fibroblast proliferation; viral envelope fusion with host membrane; negative regulation of protein import into nucleus, translocation; positive regulation of glomerular filtration; tissue regeneration; negative regulation of interferon-gamma production; regulation of growth; positive regulation of phagocytosis; protein kinase B signaling cascade; negative regulation of interleukin-6 production; positive regulation of TOR signaling pathway; virion attachment, binding of host cell surface receptor; organ regeneration; activation of protein kinase B; negative regulation of transcription factor activity; viral genome replication; negative regulation of tumor necrosis factor production; cellular response to starvation; positive regulation of peptidyl-serine phosphorylation; phagocytosis; cell-substrate adhesion; positive regulation of protein kinase B signaling cascade; peptidyl-serine phosphorylation; positive regulation of protein kinase activity; positive regulation of protein amino acid phosphorylation; negative regulation of transcription, DNA-dependent; positive regulation of cytokine and chemokine mediated signaling pathway; blood coagulation; negative regulation of interleukin-1 secretion; apoptotic cell clearance; negative regulation of apoptosis
Research Articles on GAS6
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Products associated with GAS6 recombinant protein
Pathways associated with GAS6 recombinant protein
Organs/Tissues associated with GAS6 recombinant protein
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