NP_001041643.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
NCBI Official Full Name
growth hormone receptor isoform 2
NCBI Official Synonym Full Names
growth hormone receptor
NCBI Official Synonym Symbols
NCBI Protein Information
growth hormone receptor; GH receptor; somatotropin receptor; growth hormone receptor/binding protein; Growth hormone receptor precursor (GH receptor) (GH binding protein) (GHBP) (Serum binding protein)
UniProt Protein Name
Growth hormone receptor
UniProt Synonym Protein Names
Somatotropin receptorCleaved into the following chain:Growth hormone-binding protein; GH-binding protein; GHBP; Alternative name(s):; Serum-binding protein
UniProt Synonym Gene Names
UniProt Entry Name
GHR_MOUSE
UniProt Comments for GHR
GH receptor: Receptor for pituitary gland growth hormone involved in regulating postnatal body growth. On ligand binding, couples to the JAK2/STAT5 pathway. Defects in GHR are a cause of Laron syndrome (LARS). A severe form of growth hormone insensitivity characterized by growth impairment, short stature, dysfunctional growth hormone receptor, and failure to generate insulin-like growth factor I in response to growth hormone. Defects in GHR may be a cause of idiopathic short stature autosomal (ISSA). Short stature is defined by a subnormal rate of growth. Belongs to the type I cytokine receptor family. Type 1 subfamily. 4 isoforms of the human protein are produced by alternative splicing.
Protein type: Membrane protein, integral; Receptor, cytokine
Cellular Component: extracellular space; cell surface; mitochondrion; integral to plasma membrane; integral to membrane; extracellular region; extrinsic to membrane; cell soma; membrane; cytoplasm; plasma membrane; nucleus; receptor complex
Molecular Function: growth hormone receptor activity; hematopoietin/interferon-class (D200-domain) cytokine receptor activity; protein binding; protein homodimerization activity; growth factor binding; peptide hormone binding; SH2 domain binding; protein phosphatase binding; protein kinase binding
Biological Process: activation of JAK protein; succinate metabolic process; isoleucine metabolic process; oxaloacetate metabolic process; hormone-mediated signaling; activation of MAPK activity; cytokine and chemokine mediated signaling pathway; positive regulation of JAK-STAT cascade; regulation of multicellular organism growth; valine metabolic process; citrate metabolic process; endocytosis; positive regulation of multicellular organism growth; fatty acid metabolic process; JAK-STAT cascade; tyrosine phosphorylation of JAK2 protein; creatine metabolic process; response to estradiol stimulus; multicellular organismal metabolic process; cellular response to hormone stimulus; 2-oxoglutarate metabolic process; positive regulation of peptidyl-tyrosine phosphorylation; insulin-like growth factor receptor signaling pathway; allantoin metabolic process; creatinine metabolic process; taurine metabolic process
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Pathways associated with GHR recombinant protein
Diseases associated with GHR recombinant protein
Organs/Tissues associated with GHR recombinant protein
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