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GH1 recombinant protein :: Growth Hormone, Recombinant Recombinant Protein

Scan QR to view Datasheet Catalog #    MBS319391 GH1 recombinant protein
Unit / Price
0.1 mg  /  $185 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Growth Hormone, Recombinant (GH1), Recombinant Protein

 Also Known As   

hGH, Recombinant

 Product Synonym Names    hGH, Recombinant; Human Growth Hormone (hGH), Recombinant
 Product Gene Name   

GH1 recombinant protein

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Chromosome Location    Chromosome: 17; NC_000017.10 (61994563..61996198, complement). Location: 17q24.2
 OMIM    139250
 3D Structure    ModBase 3D Structure for P01241
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 Host    E Coli
 Species Reactivity    Human
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 Specificity    Growth Hormone, Recombinant
 Purity/Purification    >98% pure (RP-HPLC and SDS-PAGE). Purified by chromatographic techniques. Product is sterile filtered.
 Form/Format    Purified, Lyophilized. Reconstitute using sterile deionized water to a concentration >100ug/ml. Further dilutions can be made in other aqueous buffers.
 Concentration    Total protein: 1mg/ml (OD280nm, E0.1% = 0.72). Activity: 3Units/mg (lot specific)
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 Buffer    Lyophilized from sodium phosphate buffer containing mannitol
 Preservative    No Preservative
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 Preparation and Storage    The lyophilized product, though stable for 3 weeks at room temperature, is best stored at -20 degree C. After reconstitution, short term (up to 1 week) store at 2-8 degree C. Long term, add 0.1% HSA or BSA, aliquot and store at -20 degree C. Avoid multiple freeze/thaw cycles.
 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Other Notes    Small volumes of GH1 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for GH1 recombinant protein

   Recombinant Human growth hormone (hGH) is a single, non-glycosylated, polypeptide chain containing 192 amino acids. Molecular weight: 22,260Da. The sequence of the first five N-terminal amino acids was determined to be Met-Phe-Pro-Thr-Ile.
 Product Categories/Family for GH1 recombinant protein    Purified Hormones and Steroids
NCBI/Uniprot data below describe general gene information for GH1. It may not necessarily be applicable to this product.
 NCBI GI #    183157
 NCBI GeneID    2688
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 UniProt Primary Accession #    P01241 [Other Products]
 UniProt Secondary Accession #    Q14405; Q16631; Q5EB53; Q9HBZ1; Q9UMJ7; Q9UNL5 [Other Products]
 UniProt Related Accession #    P01241; Q6IYF0; Q6IYF1 [Other Products]
 Molecular Weight    24,847 Da [Similar Products]
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 NCBI Official Full Name    growth hormone
 NCBI Official Synonym Full Names    growth hormone 1
 NCBI Official Symbol    GH1 [Similar Products]
 NCBI Official Synonym Symbols   
GH; GHN; GH-N; hGH-N; IGHD1B
[Similar Products]
 NCBI Protein Information    somatotropin; pituitary growth hormone
 UniProt Protein Name    Somatotropin
 UniProt Synonym Protein Names   
Growth hormone; GH; GH-N; Growth hormone 1; Pituitary growth hormone
 Protein Family    Somatotropin
 UniProt Gene Name    GH1 [Similar Products]
 UniProt Entry Name    SOMA_HUMAN
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 NCBI Summary for GH1    The protein encoded by this gene is a member of the somatotropin/prolactin family of hormones which play an important role in growth control. The gene, along with four other related genes, is located at the growth hormone locus on chromosome 17 where they are interspersed in the same transcriptional orientation; an arrangement which is thought to have evolved by a series of gene duplications. The five genes share a remarkably high degree of sequence identity. Alternative splicing generates additional isoforms of each of the five growth hormones, leading to further diversity and potential for specialization. This particular family member is expressed in the pituitary but not in placental tissue as is the case for the other four genes in the growth hormone locus. Mutations in or deletions of the gene lead to growth hormone deficiency and short stature. [provided by RefSeq]
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 UniProt Comments for GH1    Function: Plays an important role in growth control. Its major role in stimulating body growth is to stimulate the liver and other tissues to secrete IGF-1. It stimulates both the differentiation and proliferation of myoblasts. It also stimulates amino acid uptake and protein synthesis in muscle and other tissues.

Subunit structure: Monomer, dimer, trimer, tetramer and pentamer, disulfide-linked or non-covalently associated, in homopolymeric and heteropolymeric combinations. Can also form a complex either with GHBP or with the alpha2-macroglobulin complex.

Subcellular location: Secreted.

Involvement in disease: Defects in GH1 are a cause of growth hormone deficiency isolated type 1A (IGHD1A) [

MIM:262400]; also known as pituitary dwarfism I. IGHD1A is an autosomal recessive deficiency of GH which causes short stature. IGHD1A patients have an absence of GH with severe dwarfism and often develop anti-GH antibodies when given exogenous GH. Ref.19Defects in GH1 are a cause of growth hormone deficiency isolated type 1B (IGHD1B) [

MIM:612781]; also known as dwarfism of Sindh. IGHD1B is an autosomal recessive deficiency of GH which causes short stature. IGHD1B patients have low but detectable levels of GH. Dwarfism is less severe than in IGHD1A and patients usually respond well to exogenous GH.Defects in GH1 are the cause of Kowarski syndrome (KWKS) [

MIM:262650]; also known as pituitary dwarfism VI. Ref.28 Ref.31 Ref.38Defects in GH1 are a cause of growth hormone deficiency isolated type 2 (IGHD2) [

MIM:173100]. IGHD2 is an autosomal dominant deficiency of GH which causes short stature. Clinical severity is variable. Patients have a positive response and immunologic tolerance to growth hormone therapy.

Pharmaceutical use: Available under the names Nutropin or Protropin (Genentech), Norditropin (Novo Nordisk), Genotropin (Pharmacia Upjohn), Humatrope (Eli Lilly) and Saizen or Serostim (Serono). Used for the treatment of growth hormone deficiency and for Turner's syndrome.

Miscellaneous: Circulating GH shows a great heterogeneity due to alternative splicing, differential post-translational modifications of monomeric forms, oligomerization, optional binding to 2 different GH-binding proteins, and potentially proteolytic processing.

Sequence similarities: Belongs to the somatotropin/prolactin family.
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 Research Articles on GH1    1. Decreased placental expression of hPGH, IGF-I and IGFBP-1 in pregnancies complicated by fetal growth restriction.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with GH1 recombinant proteinPathways associated with GH1 recombinant protein
 Reference Product  PubMed Publications
 PRLR recombinant protein  >1 publications with GH1 and PRLR
 Products by Pathway  Pathway Diagram
 Adipogenesis Pathway antibodies  Adipogenesis Pathway Diagram
 Cytokine-cytokine Receptor Interaction Pathway antibodies  Cytokine-cytokine Receptor Interaction Pathway Diagram
 Cytokine-cytokine Receptor Interaction Pathway antibodies  Cytokine-cytokine Receptor Interaction Pathway Diagram
 Diabetes Pathways antibodies  Diabetes Pathways Diagram
 Endochondral Ossification Pathway antibodies  Endochondral Ossification Pathway Diagram
 Jak-STAT Signaling Pathway antibodies  Jak-STAT Signaling Pathway Diagram
 Jak-STAT Signaling Pathway antibodies  Jak-STAT Signaling Pathway Diagram
 Neuroactive Ligand-receptor Interaction Pathway antibodies  Neuroactive Ligand-receptor Interaction Pathway Diagram
 Neuroactive Ligand-receptor Interaction Pathway antibodies  Neuroactive Ligand-receptor Interaction Pathway Diagram
 Synthesis, Secretion, And Deacylation Of Ghrelin Pathway antibodies  Synthesis, Secretion, And Deacylation Of Ghrelin Pathway Diagram
Diseases associated with GH1 recombinant proteinOrgans/Tissues associated with GH1 recombinant protein
 Disease Name  Pubmed Publications
 Neoplasms Antibodies  >63 publications with GH1 and Neoplasms
 Central Nervous System Diseases Antibodies  >50 publications with GH1 and Central Nervous System Diseases
 Thyroid Neoplasms Antibodies  >17 publications with GH1 and Thyroid Neoplasms
 Bone Diseases, Developmental Antibodies  >10 publications with GH1 and Bone Diseases, Developmental
 Skin Diseases Antibodies  >10 publications with GH1 and Skin Diseases
 ISOLATED GROWTH HORMONE DEFICIENCY, TYPE II Antibodies  >9 publications with GH1 and ISOLATED GROWTH HORMONE DEFICIENCY, TYPE II
 Breast Neoplasms Antibodies  >9 publications with GH1 and Breast Neoplasms
 Neoplasms, Experimental Antibodies  >8 publications with GH1 and Neoplasms, Experimental
 Adenoma Antibodies  >7 publications with GH1 and Adenoma
 Liver Neoplasms Antibodies  >6 publications with GH1 and Liver Neoplasms
 Organ/Tissue Name  Pubmed Publications
 Pituitary Gland Antibodies  >42 publications with GH1 and Pituitary Gland
 Brain Antibodies  >39 publications with GH1 and Brain
 Placenta Antibodies  >3 publications with GH1 and Placenta
 Prostate Antibodies  >2 publications with GH1 and Prostate
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