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GH1 recombinant protein :: Growth Hormone Recombinant Protein

Scan QR to view Datasheet Catalog #    MBS553233 GH1 recombinant protein
Unit / Price
0.01 mg  /  $145 +1 FREE 8GB USB
0.05 mg  /  $220 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Growth Hormone (GH1), Recombinant Protein

 Also Known As   

Mouse Growth Hormone Recombinant

 Product Synonym Names    Somatotropin; gh1; gh-1; growth hormone
 Product Gene Name   

GH1 recombinant protein

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Sequence    MATDSRTSWL LTVSLLCLLW PQEASAFPAM PLSSLFSNAV LRAQHLHQLA ADTYKEFERA YIPEGQRYSI QNAQAAFCFS ETIPAPTGKE EAQQRTDMEL LRFSLLLIQS WLGPVQFLSR IFTNSLMFGT SDRVYEKLKD LEEGIQALMQ ELEDGSPRVG QILKQTYDKF DANMRSDDAL LKNYGLLSCF KKDLHKAETY LRVMKCRRFV ESSCAF
 3D Structure    ModBase 3D Structure for P06880
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 Host    E Coli
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 Purity/Purification    >95%, as determined by SDS-PAGE and HPLC
 Form/Format    Recombinant Mouse Growth Hormone was lyophilized from 0.2 um filtered 100mM NaCl, 20mM PB, pH 7.4.
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 Domain    four helix cytokine core
 Host Note    Optimized DNA sequence encoding Mouse Growth Hormone mature chain was expressed in Escherichia Coli.
 Endotoxin    Endotoxin content was assayed using a LAL gel clot method.
Endotoxin level was found to be less than 0.1 ng/ug (1EU/ug).
 Reconstitution    A quick spin of the vial followed by reconstitution in distilled water to a concentration not less than 0.1 mg/mL. This solution can then be diluted into other buffers.
 Molecular Weight Note    Native Mouse Growth Hormone is generated by the proteolytic removal of the signal peptide and propeptide, the molecule has a calculated molecular mass of approximately 22 kDa.

Recombinant GH is a disulfide-linked homodimeric protein consisting of 191 amino acid residue subunits, and migrates as an approximately 22 kDa protein under non-reducing and reducing conditions in SDS-PAGE.
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 Preparation and Storage    The lyophilized protein is stable for at least 2 years from date of receipt at -20 degree C.
Upon reconstitution, this cytokine can be stored in working aliquots at 2 degree - 8 degree C for one month, or at -20 degree C for six months, with a carrier protein without detectable loss of activity.

Avoid repeated freeze/thaw cycles.
 Other Notes    Small volumes of GH1 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Product Description specifically for GH1 recombinant protein

   The physiological activity for which growth hormone is best known is the promotion of growth of bone, cartilage, and soft tissues. Detectable levels of growth hormone are found throughout the remainder of adulthood, suggesting other functions in addition to promotion of growth. Growth hormone may be important for the maintenance of lean body mass; most growth-promoting effects of growth hormone are mediated by IGF-1 the synthesis of which is regulated by growth hormone. The biological activities of growth hormone are mediated by receptors belonging to one of the Cytokine receptor families. Growth hormone has been shown to be produced by T- cells, B-cells, and macrophages. In human lymphocytes growth hormone appears to up-regulate its own expression. Growth hormone appears to act as an enhancer of immune responses and is produced in considerable amounts by T- helper cells.
 Product Categories/Family for GH1 recombinant protein    Cytokines
NCBI/Uniprot data below describe general gene information for GH1. It may not necessarily be applicable to this product.
 NCBI GI #    6679997
 NCBI GeneID    14599
 NCBI Accession #    NP_032143.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_008117.3 [Other Products]
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 UniProt Primary Accession #    P06880 [Other Products]
 UniProt Secondary Accession #    Q544X1 [Other Products]
 UniProt Related Accession #    P06880; Q8BK24; Q9R2C3 [Other Products]
 Molecular Weight    24,716 Da
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 NCBI Official Full Name    somatotropin
 UniProt Protein Name    Somatotropin
 UniProt Synonym Protein Names   
Growth hormone
 Protein Family    Growth hormone
 UniProt Gene Name    Gh1 [Similar Products]
 UniProt Synonym Gene Names    Gh [Similar Products]
 UniProt Entry Name    SOMA_MOUSE
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 UniProt Comments for GH1    GH: Plays an important role in growth control. Its major role in stimulating body growth is to stimulate the liver and other tissues to secrete IGF-1. It stimulates both the differentiation and proliferation of myoblasts. It also stimulates amino acid uptake and protein synthesis in muscle and other tissues. Defects in GH1 are a cause of growth hormone deficiency isolated type 1A (IGHD1A); also known as pituitary dwarfism I. IGHD1A is an autosomal recessive deficiency of GH which causes short stature. IGHD1A patients have an absence of GH with severe dwarfism and often develop anti-GH antibodies when given exogenous GH. Defects in GH1 are a cause of growth hormone deficiency isolated type 1B (IGHD1B); also known as dwarfism of Sindh. IGHD1B is an autosomal recessive deficiency of GH which causes short stature. IGHD1B patients have low but detectable levels of GH. Dwarfism is less severe than in IGHD1A and patients usually respond well to exogenous GH. Defects in GH1 are the cause of Kowarski syndrome (KWKS); also known as pituitary dwarfism VI. Defects in GH1 are a cause of growth hormone deficiency isolated type 2 (IGHD2). IGHD2 is an autosomal dominant deficiency of GH which causes short stature. Clinical severity is variable. Patients have a positive response and immunologic tolerance to growth hormone therapy. Belongs to the somatotropin/prolactin family. 4 isoforms of the human protein are produced by alternative splicing.

Protein type: Secreted; Hormone; Secreted, signal peptide

Cellular Component: extracellular space; mitochondrion; plasma membrane; extracellular region; trans-Golgi network; cytosol; nucleus; secretory granule

Molecular Function: growth hormone receptor binding; metal ion binding; hormone activity

Biological Process: response to food; response to light stimulus; positive regulation of neurogenesis; cellular response to insulin stimulus; neuroblast proliferation; glucose transport; positive regulation of multicellular organism growth; regulation of steroid hormone receptor signaling pathway; signal transduction; positive regulation of growth; alveolus development
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Product References and Citations for GH1 recombinant protein

   Growth Hormone secretagogues and Growth Hormone releasing peptides act as orthosteric super-agonists but not allosteric regulators for activation of the g protein go1 by the ghrelin receptor .Mol. Pharmacol., Oct 2009; 76: 802 - 811.
statement by the Growth Hormone research society on the gh/igf-i axis in extending health span .J Gerontol A Biol Sci Med Sci, Oct 2009; 64A: 1039 - 1044.
the p561t polymorphism of the Growth Hormone receptor gene has an inhibitory effect on mandibular growth in young children .Eur J Orthod, Oct 2009; 31: 536 - 541.
central ghrelin regulates peripheral lipid metabolism in a Growth Hormone-independent fashion .Endocrinology, Oct 2009; 150: 4562 - 4574.
effects of syndyphalin-33 on feed intake and circulating measures of Growth Hormone, cortisol, and immune cell populations in the recently weaned pig .J Anim Sci, Oct 2009; 87: 3218 - 3225.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Pathways associated with GH1 recombinant proteinDiseases associated with GH1 recombinant protein
 Products by Pathway  Pathway Diagram
 Adipogenesis Pathway antibodies  Adipogenesis Pathway Diagram
 Diabetes Pathways antibodies  Diabetes Pathways Diagram
 Jak-STAT Signaling Pathway antibodies  Jak-STAT Signaling Pathway Diagram
 Jak-STAT Signaling Pathway antibodies  Jak-STAT Signaling Pathway Diagram
 Neuroactive Ligand-receptor Interaction Pathway antibodies  Neuroactive Ligand-receptor Interaction Pathway Diagram
 Neuroactive Ligand-receptor Interaction Pathway antibodies  Neuroactive Ligand-receptor Interaction Pathway Diagram
 Synthesis, Secretion, And Deacylation Of Ghrelin Pathway antibodies  Synthesis, Secretion, And Deacylation Of Ghrelin Pathway Diagram
 Disease Name  Pubmed Publications
 Neoplasms Antibodies  >3921 publications with GH1 and Neoplasms
 Pituitary Neoplasms Antibodies  >2645 publications with GH1 and Pituitary Neoplasms
 Adenoma Antibodies  >2016 publications with GH1 and Adenoma
 Insulin Resistance Antibodies  >1334 publications with GH1 and Insulin Resistance
 Body Weight Changes Antibodies  >1102 publications with GH1 and Body Weight Changes
 Bone Diseases, Developmental Antibodies  >1049 publications with GH1 and Bone Diseases, Developmental
 Gonadal Disorders Antibodies  >966 publications with GH1 and Gonadal Disorders
 Heart Diseases Antibodies  >937 publications with GH1 and Heart Diseases
 Congenital Abnormalities Antibodies  >930 publications with GH1 and Congenital Abnormalities
 Kidney Diseases Antibodies  >621 publications with GH1 and Kidney Diseases
Organs/Tissues associated with GH1 recombinant protein
 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >6792 publications with GH1 and Brain
 Pituitary Gland Antibodies  >4958 publications with GH1 and Pituitary Gland
 Embryonic Tissue Antibodies  >321 publications with GH1 and Embryonic Tissue
 Uncharacterized Tissue Antibodies  >5 publications with GH1 and Uncharacterized Tissue
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