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oGHBP recombinant protein :: Growth Hormone Recombinant Protein

Scan QR to view Datasheet Catalog #    MBS142346 oGHBP recombinant protein
Unit / Price
0.005 mg  /  $140 +1 FREE 8GB USB
0.02 mg  /  $205 +1 FREE 8GB USB
1 mg  /  $3,280 +4 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Growth Hormone (oGHBP), Recombinant Protein

 Also Known As   

Recombinant Ovine Growth Hormone Binding Protein

 Product Synonym Names    GHBP Ovine; Growth Hormone Binding Protein Ovine Recombinant; GHR; GHBP; GH receptor; Somatotropin receptor
 Product Gene Name   

oGHBP recombinant protein

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Sequence    The sequence of the first five N-terminal amino acids was determined and was found to be Ala-Phe-Se r-Gly-Ser
 3D Structure    ModBase 3D Structure for Q28575
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 Host    E Coli
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 Purity/Purification    Greater than 95.0% as determined by: (a) Analysis by SEC-HPLC. (b) Analysis by SDS-PAGE.
 Form/Format    GHBP was lyophilized from a concentrated (1mg/ml) solution with 0.0045mM NaHCO3.
Sterile Filtered White lyophilized (freeze-dried) powder.
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 Solubility    It is recommended to reconstitute the lyophilized Growth Hormone Binding Protein in sterile 18M Omega -cm H2O not less than 100 ug/ml, which can then be further diluted to other aqueous solutions.
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 Preparation and Storage    Lyophilized Growth Hormone Binding Protein although stable at room temperature for 3 weeks, should be stored desiccated below -18 degree C. Upon reconstitution GHBP should be stored at 4 degree C between 2-7 days and for future use below -18 degree C.For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Please prevent freeze-thaw cycles.
 Other Notes    Small volumes of oGHBP recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for oGHBP recombinant protein

   Description: Growth Hormone Binding Protein Ovine Recombinant produced in E Coli is a single, non-glycosylated, polypeptide chain containing 237 amino acids and having a molecular mass of 28 kDa. GHBP is purified by proprietary chromatographic techniques.

Introduction: GHBP is a transmembrane receptor for growth hormone. Binding of growth hormone to the receptor leads to receptor dimerization and the activation of an intra- and intercellular signal transduction pathway leading to growth. A common alternate allele of this gene, called GHRd3, lacks exon three and has been well-characterized. Mutations in this gene have been associated with Laron syndrome, also known as the growth hormone insensitivity syndrome (GHIS), a disorder characterized by short stature. Other splice variants, including one encoding a soluble form of the protein (GHRtr), have been observed but have not been thoroughly characterized.
 Product Categories/Family for oGHBP recombinant protein    CYTOKINES AND GROWTH FACTORS; Growth Factors; Growth Hormone
NCBI/Uniprot data below describe general gene information for oGHBP. It may not necessarily be applicable to this product.
 NCBI GI #    57164345
 NCBI GeneID    443333
 NCBI Accession #    NP_001009323.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_001009323.2 [Other Products]
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 UniProt Primary Accession #    Q28575 [Other Products]
 UniProt Related Accession #    Q28575 [Other Products]
 Molecular Weight    70,845 Da
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 NCBI Official Full Name    growth hormone receptor
 NCBI Official Symbol    GHR [Similar Products]
 NCBI Protein Information    growth hormone receptor; GH receptor; somatotropin receptor
 UniProt Protein Name    Growth hormone receptor
 UniProt Synonym Protein Names   
Somatotropin receptorGrowth hormone-binding protein; GH-binding protein; GHBPAlternative name(s):Serum-binding protein
 Protein Family    Growth hormone
 UniProt Gene Name    GHR [Similar Products]
 UniProt Synonym Gene Names    GH receptor; GH-binding protein; GHBP [Similar Products]
 UniProt Entry Name    GHR_SHEEP
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 UniProt Comments for oGHBP    Receptor for pituitary gland growth hormone involved in regulating postnatal body growth. On ligand binding, couples to, and activates the JAK2/STAT5 pathway ().
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 Research Articles on oGHBP    1. results suggest that GH-R, IGF-1 and IGF-IR mRNA expression in the skin of sheep follows specific developmental patterns
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Pathways associated with oGHBP recombinant proteinDiseases associated with oGHBP recombinant protein
 Products by Pathway  Pathway Diagram
 Cytokine-cytokine Receptor Interaction Pathway antibodies  Cytokine-cytokine Receptor Interaction Pathway Diagram
 Cytokine-cytokine Receptor Interaction Pathway antibodies  Cytokine-cytokine Receptor Interaction Pathway Diagram
 Jak-STAT Signaling Pathway antibodies  Jak-STAT Signaling Pathway Diagram
 Jak-STAT Signaling Pathway antibodies  Jak-STAT Signaling Pathway Diagram
 Neuroactive Ligand-receptor Interaction Pathway antibodies  Neuroactive Ligand-receptor Interaction Pathway Diagram
 Neuroactive Ligand-receptor Interaction Pathway antibodies  Neuroactive Ligand-receptor Interaction Pathway Diagram
 PI3K-Akt Signaling Pathway antibodies  PI3K-Akt Signaling Pathway Diagram
 PI3K-Akt Signaling Pathway antibodies  PI3K-Akt Signaling Pathway Diagram
 Disease Name  Pubmed Publications
 Nervous System Diseases Antibodies  >86 publications with oGHBP and Nervous System Diseases
 Laron Syndrome Antibodies  >81 publications with oGHBP and Laron Syndrome
 Disease Models, Animal Antibodies  >66 publications with oGHBP and Disease Models, Animal
 Weight Gain Antibodies  >51 publications with oGHBP and Weight Gain
 Liver Diseases Antibodies  >50 publications with oGHBP and Liver Diseases
 Carcinoma Antibodies  >49 publications with oGHBP and Carcinoma
 Necrosis Antibodies  >35 publications with oGHBP and Necrosis
 Kidney Diseases Antibodies  >35 publications with oGHBP and Kidney Diseases
 Inflammation Antibodies  >29 publications with oGHBP and Inflammation
 Fatty Liver Antibodies  >25 publications with oGHBP and Fatty Liver
Organs/Tissues associated with oGHBP recombinant protein
 Organ/Tissue Name  Pubmed Publications
 Digestive Antibodies  >298 publications with oGHBP and Digestive
 Bone Antibodies  >94 publications with oGHBP and Bone
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