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raGHBP recombinant protein :: Growth Hormone Recombinant Protein

Scan QR to view Datasheet Catalog #    MBS143305 raGHBP recombinant protein
Unit / Price
0.005 mg  /  $140 +1 FREE 8GB USB
0.02 mg  /  $205 +1 FREE 8GB USB
1 mg  /  $3,280 +4 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Growth Hormone (raGHBP), Recombinant Protein

★Popular Item★
 Also Known As   

Recombinant Rabbit Growth Hormone Binding Protein

 Product Synonym Names    GHBP Rabbit; Growth Hormone Binding Protein Rabbit Recombinant; GHR; GHBP; GH receptor; Somatotropin receptor
 Product Gene Name   

raGHBP recombinant protein

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Sequence    AFSGSEATPA TLGRASESVQ RVHPGLGTNS SGKPKFTKCR SPELETFSCH WTDGVHHGLK SPGSVQLFYI RRNTQEWTQE WKECPDYVSA GENSCYFNSS YTSIWIPYCI KLTNNGGMVD QKCFSVEEIV QPDPPIGLNW TLLNVSLTGI HADIQVRWEP PPNADVQKGW IVLEYELQYK EVNETQWKMM DPVLSTSVPV YSLRLDKEYE VRVRSRQRSS EKYGEFSEVL YVTLPQMSPF TCEEDFRFP
 3D Structure    ModBase 3D Structure for P19941
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 Purity/Purification    Greater than 98.0% as determined bySDS-PAGE.
 Form/Format    The Growth Hormone Binding Protein Rabbit was lyophilized from a concentrated (1mg/ml) solution with 0.0045mM NaHCO3.
Sterile Filtered White lyophilized (freeze-dried) powder.
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 Source    Escherichia Coli.
 Solubility    It is recommended to reconstitute the lyophilized GHBP Rabbit in sterile 0.4% NaHCO3 pH 10, not less than 100ug/ml, which can then be further diluted to other aqueous solutions.
 Biological Activity    Evidended by its ability of forming 2:1 complex with non-primate Growth Hormones.
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 Preparation and Storage    Lyophilized Growth Hormone Binding Protein Rabbit although stable at room temperature for 3 weeks, should be stored desiccated below -18 degree C. Upon reconstitution GHBP Rabbit should be stored at 4 degree C between 2-7 days and for future use below -18 degree C.For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Please prevent freeze-thaw cycles.
 Other Notes    Small volumes of raGHBP recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for raGHBP recombinant protein

   Description: Growth Hormone Binding Protein Rabbit Extracellular Domain Recombinant produced in E.Coli is a single, non-glycosylated, polypeptide chain containing 249 amino acids and having a molecular mass of 28 kDa. GHBP Rabbit is purified by proprietary chromatographic techniques.

Introduction:
GHBP is a transmembrane receptor for growth hormone. Binding of growth hormone to the receptor leads to receptor dimerization and the activation of an intra- and intercellular signal transduction pathway leading to growth. A common alternate allele of this gene, called GHRd3, lacks exon three and has been well-characterized. Mutations in this gene have been associated with Laron syndrome, also known as the growth hormone insensitivity syndrome (GHIS), a disorder characterized by short stature. Other splice variants, including one encoding a soluble form of the protein (GHRtr), have been observed but have not been thoroughly characterized.
 Product Categories/Family for raGHBP recombinant protein    CYTOKINES AND GROWTH FACTORS; Growth Factors; Growth Hormone
NCBI/Uniprot data below describe general gene information for raGHBP. It may not necessarily be applicable to this product.
 NCBI GI #    130492708
 NCBI GeneID    100009325
 NCBI Accession #    NP_001076105.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_001082636.1 [Other Products]
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 UniProt Primary Accession #    P19941 [Other Products]
 UniProt Related Accession #    P19941 [Other Products]
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 NCBI Official Full Name    growth hormone receptor
 NCBI Official Symbol    GHR [Similar Products]
 NCBI Protein Information    growth hormone receptor; GH receptor; somatotropin receptor
 UniProt Protein Name    Growth hormone receptor
 UniProt Synonym Protein Names   
Somatotropin receptorGrowth hormone-binding protein; GH-binding protein; GHBPAlternative name(s):Serum-binding protein
 Protein Family    Growth hormone
 UniProt Gene Name    GHR [Similar Products]
 UniProt Synonym Gene Names    GH receptor; GH-binding protein; GHBP [Similar Products]
 UniProt Entry Name    GHR_RABIT
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 UniProt Comments for raGHBP    GH receptor: Receptor for pituitary gland growth hormone involved in regulating postnatal body growth. On ligand binding, couples to the JAK2/STAT5 pathway. Defects in GHR are a cause of Laron syndrome (LARS). A severe form of growth hormone insensitivity characterized by growth impairment, short stature, dysfunctional growth hormone receptor, and failure to generate insulin-like growth factor I in response to growth hormone. Defects in GHR may be a cause of idiopathic short stature autosomal (ISSA). Short stature is defined by a subnormal rate of growth. Belongs to the type I cytokine receptor family. Type 1 subfamily. 4 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, integral; Receptor, cytokine
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 Research Articles on raGHBP    1. Jak2 binding to the growth hormone receptor prevents endocytosis in a non-catalytic manner
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with raGHBP recombinant proteinPathways associated with raGHBP recombinant protein
 Reference Product  PubMed Publications
 JAK2 recombinant protein  >175 publications with raGHBP and JAK2
 STAT5B recombinant protein  >62 publications with raGHBP and STAT5B
 PRL recombinant protein  >52 publications with raGHBP and PRL
 SOCS3 recombinant protein  >21 publications with raGHBP and SOCS3
 GH1 recombinant protein  >21 publications with raGHBP and GH1
 SOCS2 recombinant protein  >16 publications with raGHBP and SOCS2
 JAK1 recombinant protein  >5 publications with raGHBP and JAK1
 INS recombinant protein  >5 publications with raGHBP and INS
 TYK2 recombinant protein  >4 publications with raGHBP and TYK2
 Products by Pathway  Pathway Diagram
 Cytokine-cytokine Receptor Interaction Pathway antibodies  Cytokine-cytokine Receptor Interaction Pathway Diagram
 Cytokine-cytokine Receptor Interaction Pathway antibodies  Cytokine-cytokine Receptor Interaction Pathway Diagram
 Jak-STAT Signaling Pathway antibodies  Jak-STAT Signaling Pathway Diagram
 Jak-STAT Signaling Pathway antibodies  Jak-STAT Signaling Pathway Diagram
 Neuroactive Ligand-receptor Interaction Pathway antibodies  Neuroactive Ligand-receptor Interaction Pathway Diagram
 Neuroactive Ligand-receptor Interaction Pathway antibodies  Neuroactive Ligand-receptor Interaction Pathway Diagram
 PI3K-Akt Signaling Pathway antibodies  PI3K-Akt Signaling Pathway Diagram
 PI3K-Akt Signaling Pathway antibodies  PI3K-Akt Signaling Pathway Diagram
Diseases associated with raGHBP recombinant proteinOrgans/Tissues associated with raGHBP recombinant protein
 Disease Name  Pubmed Publications
 Nervous System Diseases Antibodies  >86 publications with raGHBP and Nervous System Diseases
 Laron Syndrome Antibodies  >81 publications with raGHBP and Laron Syndrome
 Disease Models, Animal Antibodies  >66 publications with raGHBP and Disease Models, Animal
 Weight Gain Antibodies  >51 publications with raGHBP and Weight Gain
 Liver Diseases Antibodies  >50 publications with raGHBP and Liver Diseases
 Carcinoma Antibodies  >49 publications with raGHBP and Carcinoma
 Necrosis Antibodies  >35 publications with raGHBP and Necrosis
 Kidney Diseases Antibodies  >35 publications with raGHBP and Kidney Diseases
 Inflammation Antibodies  >29 publications with raGHBP and Inflammation
 Fatty Liver Antibodies  >25 publications with raGHBP and Fatty Liver
 Organ/Tissue Name  Pubmed Publications
 Eye Antibodies  >17 publications with raGHBP and Eye
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