NP_034964.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Related Accession #
Molecular Weight
42,921 Da
NCBI Official Full Name
growth/differentiation factor 8 preproprotein
NCBI Official Synonym Full Names
myostatin
NCBI Official Synonym Symbols
NCBI Protein Information
growth/differentiation factor 8
UniProt Protein Name
Growth/differentiation factor 8
UniProt Synonym Protein Names
Myostatin
UniProt Synonym Gene Names
NCBI Summary for Mstn
This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate each subunit of the disulfide-linked homodimer. This protein negatively regulates skeletal muscle cell proliferation and differentiation. Homozygous knockout mice for this gene exhibit increased muscle mass and bone density, and reduced adiposity. [provided by RefSeq, Jul 2016]
UniProt Comments for Mstn
Acts specifically as a negative regulator of skeletal muscle growth.
Research Articles on Mstn
Precautions
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Disclaimer
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Products associated with Mstn recombinant protein
Pathways associated with Mstn recombinant protein
Diseases associated with Mstn recombinant protein
Organs/Tissues associated with Mstn recombinant protein
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