Antibody Protein ELISA Kit from MyBioSource header Telephone 1.858.633.0165          
1.855.MyBioSource
Fax 1.858.633.0166    Email sales@mybiosource.com 
tel/fax
menu1 Home Products Ordering Company Help menu7
bottom
   MyBioSource rightarrow Recombinant Protein rightarrow GDF9  rightarrow LOG IN  rightarrow MY ACCOUNT  rightarrow CART CONTENTS  rightarrow CHECKOUT 
horiz bar
MyBioSource Menu separator
separator
ELISA Kit ELISA Kit
CLIA Kit CLIA Kit
PCR Kit PCR Kit
Monoclonal Antibody Monoclonal Antibody
Polyclonal Antibody Polyclonal Antibody
Secondary Antibody Secondary Antibody
Antigen Antigen
Biochemical Biochemical
cDNA Clone cDNA Clone
siRNA siRNA
Peptide Peptide
Recombinant/Purified Protein Rec./Purified Protein

Custom ELISA Kit Custom ELISA Kit
Custom Protein Custom Protein
Custom Antibody Custom Antibody
Antibody Matched Pairs Antibody Matched Pairs
Antibody & Corresponding Blocking Peptide Pairs Antibody Peptide Pairs
Phospho-Specific Antibodies Phospho Antibodies
Products by Disease Products by Disease
Products by Pathway Products by Pathway
Products by Tissue Products by Tissue

arrow Advanced Search
arrow Submit Technical Q&A
arrow International Distributors
arrow Contact Us
separator
Our Best Sellers moreseparator
separator
 • VRK2 Antibody
 • CLN5 Antibody
 • Apelin 12 (AP12) ELISA Kit
 • Actin Gamma 1 (ACTG1) ELISA Kit
 • Helicobacter Pylori Siga (HP-Siga) ELISA Kit
 • Mannose (MN) ELISA Kit
 • Rap Guanine Nucleotide Exchange Factor 1 (RAPGEF1) ELISA Kit
 • Renin ELISA Kit
 • Clusterin ELISA Kit
 • A Disintegrin and Metalloprotease 2 (ADAM2) ELISA Kit
 • Soluble P53 (SP53) ELISA Kit
 • Lipid Peroxide (LPO) ELISA Kit
 • Interleukin 9 (IL-9) ELISA Kit
 • Soluble Interleukin 7 Receptor (SIL-7R-CD127) ELISA Kit
 downarrow more ...
separator
separator
DatasheetFull DatasheetPrinter Friendly DatasheetPrint This DatasheetAdd to Compare ListHave Questions? Ask UsRequest for a Quotation today

GDF9 recombinant protein :: Growth/differentiation factor 9 Recombinant Protein

Scan QR to view Datasheet Catalog #    MBS1071262
SDS-PAGE
Unit / Price
0.01 mg (E-Coli)  /  $110 +1 FREE 8GB USB
0.05 mg (E-Coli)  /  $190 +1 FREE 8GB USB
0.1 mg (E-Coli)  /  $285 +1 FREE 8GB USB
0.2 mg (E-Coli)  /  $460 +1 FREE 8GB USB
0.05 mg (Yeast)  /  $695 +1 FREE 8GB USB
0.5 mg (E-Coli)  /  $750 +1 FREE 8GB USB
0.05 mg (Baculovirus)  /  $845 +1 FREE 8GB USB
0.2 mg (Yeast)  /  $935 +1 FREE 8GB USB
0.5 mg (Yeast)  /  $1,050 +1 FREE 8GB USB
0.1 mg (Baculovirus)  /  $1,065 +1 FREE 8GB USB
0.05 mg (Mammalian-Cell)  /  $1,085 +1 FREE 8GB USB
1 mg (E-Coli)  /  $1,180 +1 FREE 8GB USB
0.5 mg (Baculovirus)  /  $1,545 +1 FREE 8GB USB
1 mg (Yeast)  /  $1,595 +1 FREE 8GB USB
0.1 mg (Mammalian-Cell)  /  $1,660 +2 FREE 8GB USB
1 mg (Baculovirus)  /  $2,070 +2 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Growth/differentiation factor 9 (GDF9), Recombinant Protein

 Also Known As   

Recombinant Human Growth/differentiation factor 9

 Product Gene Name   

GDF9 recombinant protein

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
Table BarTOPTable Bar
 Sequence Positions    320-454aa; Full Length
 Sequence    GQETVSSELK KPLGPASFNL SEYFRQFLLP QNECELHDFR LSFSQLKWDN WIVAPHRYNP RYCKGDCPRA VGHRYGSPVH TMVQNIIYEK LDSSVPRPSC VPAKYSPLSV LTIEPDGSIA YKEYEDMIAT KCTCR
 OMIM    601918
 3D Structure    ModBase 3D Structure for O60383
Section Bar
 Host    E Coli or Yeast or Baculovirus or Mammalian Cell
Section Bar
 Purity/Purification    Greater than 90% as determined by SDS-PAGE.
 Form/Format    Liquid containing glycerol
 Tag Information    This protein contains an N-terminal tag and may also contain a C-terminal Myc-tag. N-terminal host tags may vary (His, His-SUMO, His-B2M, GST). Tag types are determined by various factors including tag-protein stability and, therefore, are subject to change; please inquire for tag information.
 Sterility    Sterile filter available upon request.
 Endotoxin    Low endotoxin available upon request.
Section Bar
Section Bar
 Preparation and Storage    Store at -20 degree C, for extended storage, conserve at -20 degree C or -80 degree C.
 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Other Notes    Small volumes of GDF9 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Table BarTOPTable Bar
 

Product Description specifically for GDF9 recombinant protein

   Required for ovarian folliculogenesis. Promotes primordial follicle development. Stimulates granulosa cell proliferation. Promotes cell transition from G0/G1 to S and G2/M phases, through an increase of CCND1 and CCNE1 expression, and RB1 phosphorylation. It regulates STAR expression and cAMP-dependent progesterone release in granulosa and thecal cells. Attenuates the suppressive effects of activin A on STAR expression and progesterone production by increasing the expression of inhibin B. It suppresses FST and FSTL3 production in granulosa-lutein cells.
 Product Categories/Family for GDF9 recombinant protein    Cardiovascular
Section Bar
 SDS-PAGE of GDF9 recombinant protein    GDF9 recombinant protein SDS-PAGE image
(Note: Representative image, actual molecular weight may vary depending on Tag type and expression host)
Table BarTOPTable Bar
NCBI/Uniprot data below describe general gene information for GDF9. It may not necessarily be applicable to this product.
 NCBI GI #    572152931
 NCBI GeneID    2661
 NCBI Accession #    NP_001275753.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_001288824.2 [Other Products]
Section Bar
 UniProt Primary Accession #    O60383 [Other Products]
 UniProt Secondary Accession #    Q4VAW5 [Other Products]
 UniProt Related Accession #    O60383 [Other Products]
 Molecular Weight    42.9kD
Table BarTOPTable Bar
 NCBI Official Full Name    growth/differentiation factor 9 isoform 2
 NCBI Official Synonym Full Names    growth differentiation factor 9
 NCBI Official Symbol    GDF9 [Similar Products]
 NCBI Protein Information    growth/differentiation factor 9
 UniProt Protein Name    Growth/differentiation factor 9
 Protein Family    Growth/differentiation factor
 UniProt Gene Name    GDF9 [Similar Products]
 UniProt Synonym Gene Names    GDF-9 [Similar Products]
 UniProt Entry Name    GDF9_HUMAN
Section Bar
 NCBI Summary for GDF9    This gene encodes a member of the transforming growth factor-beta superfamily. The encoded preproprotein is processed into a secreted factor that is required for ovarian folliculogenesis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2014]
Section Bar
 UniProt Comments for GDF9    GDF9: Required for ovarian folliculogenesis. Promotes primordial follicle development. Stimulates granulosa cell proliferation. Promotes cell transition from G0/G1 to S and G2/M phases, through an increase of CCND1 and CCNE1 expression, and RB1 phosphorylation. It regulates STAR expression and cAMP-dependent progesterone release in granulosa and thecal cells. Attenuates the suppressive effects of activin A on STAR expression and progesterone production by increasing the expression of inhibin B. It suppresses FST and FSTL3 production in granulosa-lutein cells. Altered GDF9 function may be involved in ovarian disorders. Rare variants in GDF9 have been found in patients with premature ovarian failure and mothers of dizygotic twins. Belongs to the TGF-beta family.

Protein type: Cytokine; Secreted; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 5q31.1

Cellular Component: cytoplasm; extracellular space

Molecular Function: cytokine activity; growth factor activity; transforming growth factor beta receptor binding

Biological Process: BMP signaling pathway; cell development; female gamete generation; negative regulation of cell growth; oocyte growth; positive regulation of cell proliferation; regulation of apoptosis; regulation of MAPKKK cascade; transforming growth factor beta receptor signaling pathway
Table BarTOPTable Bar
 

Product References and Citations for GDF9 recombinant protein

   The DNA sequence and comparative analysis of human chromosome 5.Schmutz J., Martin J., Terry A., Couronne O., Grimwood J., Lowry S., Gordon L.A., Scott D., Xie G., Huang W., Hellsten U., Tran-Gyamfi M., She X., Prabhakar S., Aerts A., Altherr M., Bajorek E., Black S., Branscomb E., Caoile C., Challacombe J.F., Chan Y.M., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Glavina T., Gomez M., Gonzales E., Goodstein D., Grigoriev I., Groza M., Hammon N., Hawkins T., Haydu L., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Lopez F., Lou Y., Martinez D., Medina C., Morgan J., Nandkeshwar R., Noonan J.P., Pitluck S., Pollard M., Predki P., Priest J., Ramirez L., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wheeler J., Wu K., Yang J., Dickson M., Cheng J.-F., Eichler E.E., Olsen A., Pennacchio L.A., Rokhsar D.S., Richardson P., Lucas S.M., Myers R.M., Rubin E.M.Nature 431:268-274(2004) Human growth differentiation factor 9 (GDF-9) and its novel homolog GDF-9B are expressed in oocytes during early folliculogenesis.Aaltonen J., Laitinen M.P., Vuojolainen K., Jaatinen R., Horelli-Kuitunen N., Seppae L., Louhio H., Tuuri T., Sjoeberg J., Buetzow R., Hovatta O., Dale L., Ritvos O.J. Clin. Endocrinol. Metab. 84:2744-2750(1999) Growth differentiation factor-9 inhibits 3'5'-adenosine monophosphate-stimulated steroidogenesis in human granulosa and theca cells.Yamamoto N., Christenson L.K., McAllister J.M., Strauss J.F. IIIJ. Clin. Endocrinol. Metab. 87:2849-2856(2002) ErratumYamamoto N., Christenson L.K., McAllister J.M., Strauss J.F. IIIJ. Clin. Endocrinol. Metab. 87:4495-4495(2002) Phosphorylation of bone morphogenetic protein-15 and growth and differentiation factor-9 plays a critical role in determining agonistic or antagonistic functions.McMahon H.E., Sharma S., Shimasaki S.Endocrinology 149:812-817(2008) Effects of growth differentiation factor 9 on cell cycle regulators and ERK42/44 in human granulosa cell proliferation.Huang Q., Cheung A.P., Zhang Y., Huang H.F., Auersperg N., Leung P.C.Am. J. Physiol. 296:E1344-E1353(2009) Golgi apparatus casein kinase phosphorylates bioactive Ser-6 of bone morphogenetic protein 15 and growth and differentiation factor 9.Tibaldi E., Arrigoni G., Martinez H.M., Inagaki K., Shimasaki S., Pinna L.A.FEBS Lett. 584:801-805(2010) Growth differentiation factor 9 reverses activin A suppression of steroidogenic acute regulatory protein expression and progesterone production in human granulosa-lutein cells.Shi F.T., Cheung A.P., Klausen C., Huang H.F., Leung P.C.J. Clin. Endocrinol. Metab. 95:E172-E180(2010) Growth differentiating factor 9 (GDF9) and bone morphogenetic protein 15 both activate development of human primordial follicles in vitro, with seemingly more beneficial effects of GDF9.Kedem A., Fisch B., Garor R., Ben-Zaken A., Gizunterman T., Felz C., Ben-Haroush A., Kravarusic D., Abir R.J. Clin. Endocrinol. Metab. 96:E1246-E1254(2011) Growth differentiation factor 9 (GDF9) suppresses follistatin and follistatin-like 3 production in human granulosa-lutein cells.Shi F.T., Cheung A.P., Huang H.F., Leung P.C.PLoS ONE 6:E22866-E22866(2011) The ratio of growth differentiation factor 9 bone morphogenetic protein 15 mRNA expression is tightly co-regulated and differs between species over a wide range of ovulation rates.Crawford J.L., McNatty K.P.Mol. Cell. Endocrinol. 348:339-343(2012) Mutational screening of the coding region of growth differentiation factor 9 gene in Indian women with ovarian failure.Dixit H., Rao L.K., Padmalatha V., Kanakavalli M., Deenadayal M., Gupta N., Chakravarty B., Singh L.Menopause 12:749-754(2005) Mutations and sequence variants in GDF9 and BMP15 in patients with premature ovarian failure.Laissue P., Christin-Maitre S., Touraine P., Kuttenn F., Ritvos O., Aittomaki K., Bourcigaux N., Jacquesson L., Bouchard P., Frydman R., Dewailly D., Reyss A.-C., Jeffery L., Bachelot A., Massin N., Fellous M., Veitia R.A.Eur. J. Endocrinol. 154:739-744(2006) Novel variants in growth differentiation factor 9 in mothers of dizygotic twins.Palmer J.S., Zhao Z.Z., Hoekstra C., Hayward N.K., Webb P.M., Whiteman D.C., Martin N.G., Boomsma D.I., Duffy D.L., Montgomery G.W.J. Clin. Endocrinol. Metab. 91:4713-4716(2006) Growth differentiating factor-9 mutations may be associated with premature ovarian failure.Kovanci E., Rohozinski J., Simpson J.L., Heard M.J., Bishop C.E., Carson S.A.Fertil. Steril. 87:143-146(2007) Analyses of GDF9 mutation in 100 Chinese women with premature ovarian failure.Zhao H., Qin Y., Kovanci E., Simpson J.L., Chen Z.J., Rajkovic A.Fertil. Steril. 88:1474-1476(2007) Analyses of growth differentiation factor 9 (GDF9) and bone morphogenetic protein 15 (BMP15) mutation in Chinese women with premature ovarian failure.Wang B., Wen Q., Ni F., Zhou S., Wang J., Cao Y., Ma X.Clin. Endocrinol. (Oxf.) 72:135-136(2010)
Section Bar
 Research Articles on GDF9    1. results support a model of activation for human GDF9 dependent on cumulin formation through heterodimerization with BMP15. Oocyte-secreted cumulin is likely to be a central regulator of fertility in mono-ovular mammals.
Table BarTOPTable Bar
 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
Table BarTOPTable Bar
Products associated with GDF9 recombinant proteinPathways associated with GDF9 recombinant protein
 Reference Product  PubMed Publications
 BMPR2 recombinant protein  >35 publications with GDF9 and BMPR2
 SMAD2 recombinant protein  >24 publications with GDF9 and SMAD2
 BMPR1B recombinant protein  >22 publications with GDF9 and BMPR1B
 HAS2 recombinant protein  >19 publications with GDF9 and HAS2
 CYP19A1 recombinant protein  >16 publications with GDF9 and CYP19A1
 FSHR recombinant protein  >15 publications with GDF9 and FSHR
 LHCGR recombinant protein  >10 publications with GDF9 and LHCGR
 TGFBR1 recombinant protein  >9 publications with GDF9 and TGFBR1
 CYP17A1 recombinant protein  >6 publications with GDF9 and CYP17A1
 KITLG recombinant protein  >2 publications with GDF9 and KITLG
 Products by Pathway  Pathway Diagram
 Ovarian Infertility Genes Pathway antibodies  Ovarian Infertility Genes Pathway Diagram
 Ovarian Steroidogenesis Pathway antibodies  Ovarian Steroidogenesis Pathway Diagram
 Ovarian Steroidogenesis Pathway antibodies  Ovarian Steroidogenesis Pathway Diagram
Diseases associated with GDF9 recombinant protein
 Disease Name  Pubmed Publications
 Infertility, Female Antibodies  >70 publications with GDF9 and Infertility, Female
 Ovarian Diseases Antibodies  >67 publications with GDF9 and Ovarian Diseases
 Polycystic Ovary Syndrome Antibodies  >18 publications with GDF9 and Polycystic Ovary Syndrome
 Infertility, Male Antibodies  >9 publications with GDF9 and Infertility, Male
 Congenital Abnormalities Antibodies  >6 publications with GDF9 and Congenital Abnormalities
 Disease Models, Animal Antibodies  >6 publications with GDF9 and Disease Models, Animal
 Necrosis Antibodies  >5 publications with GDF9 and Necrosis
 Kidney Diseases Antibodies  >4 publications with GDF9 and Kidney Diseases
 Cardiovascular Diseases Antibodies  >3 publications with GDF9 and Cardiovascular Diseases
 Prostatic Neoplasms Antibodies  >2 publications with GDF9 and Prostatic Neoplasms
Table BarTOPTable Bar
horiz bar
 SSL   Follow us on Facebook Follow us onTwitter Follow us on Google Plus Connect us on LinkedIn Subscribe to our RSS Feed for latest products and special promotions