Antibody Protein ELISA Kit from MyBioSource header Telephone 1.858.633.0165          
1.855.MyBioSource
Fax 1.858.633.0166    Email sales@mybiosource.com 
tel/fax
menu1 Home Products Ordering Company Help menu7
bottom
   MyBioSource rightarrow Recombinant Protein rightarrow Grb10  rightarrow LOG IN  rightarrow MY ACCOUNT  rightarrow CART CONTENTS  rightarrow CHECKOUT 
horiz bar
MyBioSource Menu separator
separator
ELISA Kit ELISA Kit
CLIA Kit CLIA Kit
PCR Kit PCR Kit
Monoclonal Antibody Monoclonal Antibody
Polyclonal Antibody Polyclonal Antibody
Secondary Antibody Secondary Antibody
Antigen Antigen
Biochemical Biochemical
cDNA Clone cDNA Clone
siRNA siRNA
Peptide Peptide
Recombinant/Purified Protein Rec./Purified Protein

Custom ELISA Kit Custom ELISA Kit
Custom Protein Custom Protein
Custom Antibody Custom Antibody
Antibody Matched Pairs Antibody Matched Pairs
Antibody & Corresponding Blocking Peptide Pairs Antibody Peptide Pairs
Phospho-Specific Antibodies Phospho Antibodies
Products by Disease Products by Disease
Products by Pathway Products by Pathway
Products by Tissue Products by Tissue

arrow Advanced Search
arrow Submit Technical Q&A
arrow International Distributors
arrow Contact Us
separator
Our Best Sellers moreseparator
separator
 • Rho-Associated Protein Kinase 1 (ROCK1) ELISA Kit
 • Decay Accelerating Factor (DAF) Antibody
 • SLC2A2 cDNA Clone
 • Antioncogene p21 protein ELISA Kit
 • Alpha-synuclein (SNCA) Antibody
 • Hepatitis A Virus Antibody IgG (HAV-IgG) ELISA Kit
 • PNLIPRP2 Antibody
 • Troponin T, cardiac muscle (TNNT2) Recombinant Protein
 • B-Cell Activating Factor Receptor (BAFFR) ELISA Kit
 • ALK (Phospho-Tyr1604) Antibody
 • HPRG Antibody
 • HTLV-1 TAX Antibody
 • GULP, engulfment adaptor PTB domain containing 1 (GULP1) ELISA Kit
 • NXPH1 cDNA Clone
 downarrow more ...
separator
separator
DatasheetFull DatasheetPrinter Friendly DatasheetPrint This DatasheetAdd to Compare ListHave Questions? Ask UsRequest for a Quotation today

Grb10 recombinant protein :: Growth factor receptor-bound protein 10 (Grb10) Recombinant Protein

Scan QR to view Datasheet Catalog #    MBS956222 Grb10 recombinant protein
Unit / Price
0.05 mg (E-Coli)  /  $1,020 +1 FREE 8GB USB
0.05 mg (Baculovirus)  /  $1,205 +1 FREE 8GB USB
0.2 mg (E-Coli)  /  $1,380 +1 FREE 8GB USB
0.05 mg (Mammalian-Cell)  /  $1,455 +1 FREE 8GB USB
0.2 mg (Yeast)  /  $1,465 +1 FREE 8GB USB
0.5 mg (E-Coli)  /  $1,520 +1 FREE 8GB USB
0.1 mg (Baculovirus)  /  $1,530 +1 FREE 8GB USB
0.5 mg (Yeast)  /  $1,655 +2 FREE 8GB USB
1 mg (E-Coli)  /  $2,165 +2 FREE 8GB USB
0.5 mg (Baculovirus)  /  $2,185 +2 FREE 8GB USB
0.1 mg (Mammalian-Cell)  /  $2,190 +2 FREE 8GB USB
1 mg (Yeast)  /  $2,505 +3 FREE 8GB USB
1 mg (Baculovirus)  /  $2,870 +3 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Growth factor receptor-bound protein 10 (Grb10), Recombinant Protein

 Also Known As   

Recombinant Rat Growth factor receptor-bound protein 10 (Grb10)

 Product Gene Name   

Grb10 recombinant protein

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
Table BarTOPTable Bar
 Sequence Positions    1-599aa, Full length protein
 Sequence    MNNDINSSVE SLNSACNMQS DTDTVPLLEN GQSASNQPSA SSSRGQPQAS PRQKMQRSQP VHIQPLRRLQ EEDQQLRTSS LPAIPNPFPE LAGGAPGSPP SVAPSSLPPP PSQPPAKHFP PGFQLAKLTR PGLWTKTTAR FSKRQPKNQC QTDTANAVSR IPTSQMEKLR LRKDVKVFSE DGTSKVVEIL TDMTARDLCQ LLVYKSHCVD DNSWTLVEHH PQLGLERCLE DHEIVVQVES TMPSESKFLF RKNYAKYEFF KNPVNFFPDQ MVTWCQQSNG GQAQLLQNFL NSSSCPEIQG FLQVKEVGRK SWKKLYVCLR RSGLYYSTKG TSKEPRHLQL LADLEESSIF YLIAGKKQYN APNEHGMCIK PNKAKIEMKE LRLLCAEDEQ IRTCWMTAFR LLKYGMLLYQ NYRIPQQRKG LAPPFNAPMR SVSENSLVAM DFSGQIGRVI DNPAEAQSAA LEEGHAWRKR STRMNILSSQ SPLHPSTLNS VIHRTQHWFH GRISREESHR IIKQQGLVDG LFLLRDSQSN PKAFVLTLCH QQKIRNFQIL PCEDDGQTFF TLDDGNTKFS DLIQLVDFYQ LNKGVLPCKL KHHCIRVAL
 3D Structure    ModBase 3D Structure for P0CE43
Section Bar
 Host    E Coli or Yeast or Baculovirus or Mammalian Cell
Section Bar
 Purity/Purification    >85% (SDS-PAGE) (lot specific)
 Form/Format    Liquid containing glycerol
 Tag Information    This protein contains an N-terminal tag and may also contain a C-terminal tag. Tag types are determined by various factors including tag-protein stability, please inquire for tag information.
 Sterility    Sterile filter available upon request.
 Endotoxin    Low endotoxin available upon request.
Section Bar
 Species    Rat
 Storage Buffer    Tris-based buffer, 50% glycerol
 Tag Information    Tag type will be determined during the manufacturing process
Section Bar
 Preparation and Storage    Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.
 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Other Notes    Small volumes of Grb10 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Table BarTOPTable Bar
 

Related Product Information for Grb10 recombinant protein

   The product of this gene belongs to a small family of adapter proteins that are known to interact with a number of receptor tyrosine kinases and signaling molecules. This gene encodes a growth factor receptor-binding protein that interacts with insulin receptors and insulin-like growth-factor receptors. Overexpression of some isoforms of the encoded protein inhibits tyrosine kinase activity and results in growth suppression. This gene is imprinted in a highly isoform- and tissue-specific manner. Alternatively spliced transcript variants encoding different isoforms have been identified.
NCBI/Uniprot data below describe general gene information for Grb10. It may not necessarily be applicable to this product.
 NCBI GI #    1046859290
 NCBI GeneID    498416
 NCBI Accession #    XP_017454822.1 [Other Products]
 NCBI GenBank Nucleotide #    XM_017599333.1 [Other Products]
Section Bar
 UniProt Primary Accession #    P0CE43 [Other Products]
 UniProt Related Accession #    P0CE43 [Other Products]
 Molecular Weight    67,882 Da
Table BarTOPTable Bar
 NCBI Official Full Name    growth factor receptor-bound protein 10 isoform X2
 NCBI Official Synonym Full Names    growth factor receptor bound protein 10
 NCBI Official Symbol    Grb10 [Similar Products]
 NCBI Official Synonym Symbols   
RGD1566234
[Similar Products]
 NCBI Protein Information    growth factor receptor-bound protein 10
 UniProt Protein Name    Growth factor receptor-bound protein 10
 UniProt Synonym Protein Names   
GRB10 adapter protein
 Protein Family    Growth factor receptor-bound protein
 UniProt Gene Name    Grb10 [Similar Products]
Section Bar
 UniProt Comments for Grb10    Adapter protein which modulates coupling of a number of cell surface receptor kinases with specific signaling pathways. Binds to, and suppress signals from, activated receptors tyrosine kinases, including the insulin (INSR) and insulin-like growth factor (IGF1R) receptors. The inhibitory effect can be achieved by 2 mechanisms: interference with the signaling pathway and increased receptor degradation. Delays and reduces AKT1 phosphorylation in response to insulin stimulation. Blocks association between INSR and IRS1 and IRS2 and prevents insulin-stimulated IRS1 and IRS2 tyrosine phosphorylation. Recruits NEDD4 to IGF1R, leading to IGF1R ubiquitination, increased internalization and degradation by both the proteasomal and lysosomal pathways. A similar role in the mediation of ubiquitination has also been suggested with INSR. Negatively regulates Wnt signaling by interacting with LRP6 intracellular portion and interfering with the binding of AXIN1 to LRP6. Positive regulator of the KDR/VEGFR-2 signaling pathway. May inhibit NEDD4-mediated degradation of KDR/VEGFR-2 ().
Table BarTOPTable Bar
 Research Articles on Grb10    1. In rat uterus, enforced miR199a expression suppresses cell proliferation partially through targeting Grb10.
Table BarTOPTable Bar
 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
Table BarTOPTable Bar
Pathways associated with Grb10 recombinant proteinDiseases associated with Grb10 recombinant protein
 Products by Pathway  Pathway Diagram
 EGFR1 Signaling Pathway antibodies  EGFR1 Signaling Pathway Diagram
 Insulin Signaling Pathway antibodies  Insulin Signaling Pathway Diagram
 Insulin Receptor Signalling Cascade Pathway antibodies  Insulin Receptor Signalling Cascade Pathway Diagram
 Kit Receptor Signaling Pathway antibodies  Kit Receptor Signaling Pathway Diagram
 Signal Transduction Pathway antibodies  Signal Transduction Pathway Diagram
 Signal Attenuation Pathway antibodies  Signal Attenuation Pathway Diagram
 Signaling By Insulin Receptor Pathway antibodies  Signaling By Insulin Receptor Pathway Diagram
 Signaling By SCF-KIT Pathway antibodies  Signaling By SCF-KIT Pathway Diagram
 Disease Name  Pubmed Publications
 Brain Diseases Antibodies  >15 publications with Grb10 and Brain Diseases
 Nervous System Diseases Antibodies  >15 publications with Grb10 and Nervous System Diseases
 Fetal Growth Retardation Antibodies  >11 publications with Grb10 and Fetal Growth Retardation
 Disease Models, Animal Antibodies  >8 publications with Grb10 and Disease Models, Animal
 Breast Neoplasms Antibodies  >7 publications with Grb10 and Breast Neoplasms
 Weight Loss Antibodies  >5 publications with Grb10 and Weight Loss
 Carcinoma Antibodies  >5 publications with Grb10 and Carcinoma
 Cardiovascular Diseases Antibodies  >4 publications with Grb10 and Cardiovascular Diseases
 Cognition Disorders Antibodies  >3 publications with Grb10 and Cognition Disorders
 Kidney Diseases Antibodies  >3 publications with Grb10 and Kidney Diseases
Organs/Tissues associated with Grb10 recombinant protein
 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >31 publications with Grb10 and Brain
 Embryonic Tissue Antibodies  >22 publications with Grb10 and Embryonic Tissue
 Liver Antibodies  >16 publications with Grb10 and Liver
 Placenta Antibodies  >16 publications with Grb10 and Placenta
 Kidney Antibodies  >15 publications with Grb10 and Kidney
 Heart Antibodies  >9 publications with Grb10 and Heart
 Lung Antibodies  >8 publications with Grb10 and Lung
 Ovary Antibodies  >4 publications with Grb10 and Ovary
 Adipose Tissue Antibodies  >4 publications with Grb10 and Adipose Tissue
 Connective Tissue Antibodies  >4 publications with Grb10 and Connective Tissue
Table BarTOPTable Bar
horiz bar
 SSL   Follow us on Facebook Follow us onTwitter Follow us on Google Plus Connect us on LinkedIn Subscribe to our RSS Feed for latest products and special promotions