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GNAS recombinant protein :: Guanine nucleotide-binding protein G(s) subunit alpha isoforms short Recombinant Protein

Scan QR to view Datasheet Catalog #    MBS1189964
SDS-PAGE
Unit / Price
0.01 mg (E-Coli)  /  $145 +1 FREE 8GB USB
0.05 mg (E-Coli)  /  $205 +1 FREE 8GB USB
0.1 mg (E-Coli)  /  $325 +1 FREE 8GB USB
0.2 mg (E-Coli)  /  $520 +1 FREE 8GB USB
0.5 mg (E-Coli)  /  $850 +1 FREE 8GB USB
0.05 mg (Yeast)  /  $915 +1 FREE 8GB USB
0.05 mg (Baculovirus)  /  $1,045 +1 FREE 8GB USB
0.2 mg (Yeast)  /  $1,230 +1 FREE 8GB USB
0.05 mg (Mammalian-Cell)  /  $1,290 +1 FREE 8GB USB
0.1 mg (Baculovirus)  /  $1,325 +1 FREE 8GB USB
1 mg (E-Coli)  /  $1,340 +1 FREE 8GB USB
0.5 mg (Yeast)  /  $1,390 +1 FREE 8GB USB
0.5 mg (Baculovirus)  /  $1,905 +2 FREE 8GB USB
0.1 mg (Mammalian-Cell)  /  $1,955 +2 FREE 8GB USB
1 mg (Yeast)  /  $2,115 +2 FREE 8GB USB
1 mg (Baculovirus)  /  $2,510 +3 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Guanine nucleotide-binding protein G(s) subunit alpha isoforms short (GNAS), Recombinant Protein

★Popular Item★
 Also Known As   

Recombinant Human Guanine nucleotide-binding protein G(s) subunit alpha isoforms short

 Product Synonym Names    Adenylate cyclase-stimulating G alpha protein
 Product Gene Name   

GNAS recombinant protein

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Sequence Positions    1-394aa; Full Length
 Sequence    MGCLGNSKTE DQRNEEKAQR EANKKIEKQL QKDKQVYRAT HRLLLLGAGE SGKSTIVKQM RILHVNGFNG EGGEEDPQAA RSNSDGEKAT KVQDIKNNLK EAIETIVAAM SNLVPPVELA NPENQFRVDY ILSVMNVPDF DFPPEFYEHA KALWEDEGVR ACYERSNEYQ LIDCAQYFLD KIDVIKQADY VPSDQDLLRC RVLTSGIFET KFQVDKVNFH MFDVGGQRDE RRKWIQCFND VTAIIFVVAS SSYNMVIRED NQTNRLQEAL NLFKSIWNNR WLRTISVILF LNKQDLLAEK VLAGKSKIED YFPEFARYTT PEDATPEPGE DPRVTRAKYF IRDEFLRIST ASGDGRHYCY PHFTCAVDTE NIRRVFNDCR DIIQRMHLRQ YELL
 3D Structure    ModBase 3D Structure for P63092
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 Host    E Coli or Yeast or Baculovirus or Mammalian Cell
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 Purity/Purification    Greater than 90% as determined by SDS-PAGE. (lot specific)
 Form/Format    Liquid containing glycerol
 Tag Information    This protein contains an N-terminal tag and may also contain a C-terminal tag. Tag types are determined by various factors including tag-protein stability, please inquire for tag information.
 Sterility    Sterile filter available upon request.
 Endotoxin    Low endotoxin available upon request.
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 Species    Homo sapiens (Human)
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 Preparation and Storage    Store at -20 degree C, for extended storage, conserve at -20 degree C or -80 degree C.
 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Other Notes    Small volumes of GNAS recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for GNAS recombinant protein

   Guanine nucleotide-binding proteins (G proteins) function as transducers in numerous signaling pathways controlled by G protein-coupled receptors (GPCRs). Signaling involves the activation of adenylyl cyclases, resulting in increased levels of the signaling molecule cAMP. GNAS functions downstream of several GPCRs, including beta-adrenergic receptors. Stimulates the Ras signaling pathway via RAPGEF2.
 Product Categories/Family for GNAS recombinant protein    Signal Transduction
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 SDS-PAGE of GNAS recombinant protein    GNAS recombinant protein SDS-PAGE image
(Note: Representative image, actual molecular weight may vary depending on Tag type and expression host)
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NCBI/Uniprot data below describe general gene information for GNAS. It may not necessarily be applicable to this product.
 NCBI GI #    4504047
 NCBI GeneID    2778
 NCBI Accession #    NP_000507.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_000516.5 [Other Products]
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 UniProt Primary Accession #    P63092 [Other Products]
 UniProt Related Accession #    P63092; O95467; P84996; Q5JWF2 [Other Products]
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 NCBI Official Full Name    protein GNAS isoform GNASL
 NCBI Official Synonym Full Names    GNAS complex locus
 NCBI Official Symbol    GNAS [Similar Products]
 NCBI Official Synonym Symbols   
AHO; GSA; GSP; POH; GPSA; NESP; SCG6; SgVI; GNAS1; C20orf45
[Similar Products]
 NCBI Protein Information    protein ALEX; protein GNAS; protein SCG6 (secretogranin VI)
 UniProt Protein Name    Guanine nucleotide-binding protein G(s) subunit alpha isoforms short
 UniProt Synonym Protein Names   
Adenylate cyclase-stimulating G alpha protein
 Protein Family    Protein
 UniProt Gene Name    GNAS [Similar Products]
 UniProt Synonym Gene Names    GNAS1; GSP [Similar Products]
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 NCBI Summary for GNAS    This locus has a highly complex imprinted expression pattern. It gives rise to maternally, paternally, and biallelically expressed transcripts that are derived from four alternative promoters and 5' exons. Some transcripts contain a differentially methylated region (DMR) at their 5' exons, and this DMR is commonly found in imprinted genes and correlates with transcript expression. An antisense transcript is produced from an overlapping locus on the opposite strand. One of the transcripts produced from this locus, and the antisense transcript, are paternally expressed noncoding RNAs, and may regulate imprinting in this region. In addition, one of the transcripts contains a second overlapping ORF, which encodes a structurally unrelated protein - Alex. Alternative splicing of downstream exons is also observed, which results in different forms of the stimulatory G-protein alpha subunit, a key element of the classical signal transduction pathway linking receptor-ligand interactions with the activation of adenylyl cyclase and a variety of cellular reponses. Multiple transcript variants encoding different isoforms have been found for this gene. Mutations in this gene result in pseudohypoparathyroidism type 1a, pseudohypoparathyroidism type 1b, Albright hereditary osteodystrophy, pseudopseudohypoparathyroidism, McCune-Albright syndrome, progressive osseus heteroplasia, polyostotic fibrous dysplasia of bone, and some pituitary tumors. [provided by RefSeq, Aug 2012]
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 UniProt Comments for GNAS    Guanine nucleotide-binding proteins (G proteins) function as transducers in numerous signaling pathways controlled by G protein-coupled receptors (GPCRs) (PubMed:17110384). Signaling involves the activation of adenylyl cyclases, resulting in increased levels of the signaling molecule cAMP (PubMed:26206488, PubMed:8702665). GNAS functions downstream of several GPCRs, including beta-adrenergic receptors (PubMed:21488135). Stimulates the Ras signaling pathway via RAPGEF2 (PubMed:12391161).
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Product References and Citations for GNAS recombinant protein

   "Identification by molecular cloning of two forms of the alpha-subunit of the human liver stimulatory (GS) regulatory component of adenylyl cyclase." Mattera R., Codina J., Crozat A., Kidd V., Woo S.L.C., Birnbaumer L. FEBS Lett. 206:36-42(1986)
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 Research Articles on GNAS    1. Mutations of GNAS that cause constitutive Gsalpha signaling are found in patients with McCune-Albright syndrome, fibrous dysplasia of bone, and different endocrine and non-endocrine tumors.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with GNAS recombinant proteinPathways associated with GNAS recombinant protein
 Reference Product  PubMed Publications
 TSHR recombinant protein  >17 publications with GNAS and TSHR
 ADRB2 recombinant protein  >8 publications with GNAS and ADRB2
 LHCGR recombinant protein  >2 publications with GNAS and LHCGR
 GNB1 recombinant protein  >1 publications with GNAS and GNB1
 GHRHR recombinant protein  >1 publications with GNAS and GHRHR
 Products by Pathway  Pathway Diagram
 Adrenergic Signaling In Cardiomyocytes Pathway antibodies  Adrenergic Signaling In Cardiomyocytes Pathway Diagram
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 Alcoholism Pathway antibodies  Alcoholism Pathway Diagram
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 Aldosterone Synthesis And Secretion Pathway antibodies  Aldosterone Synthesis And Secretion Pathway Diagram
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 Amoebiasis Pathway antibodies  Amoebiasis Pathway Diagram
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 Amphetamine Addiction Pathway antibodies  Amphetamine Addiction Pathway Diagram
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Diseases associated with GNAS recombinant proteinOrgans/Tissues associated with GNAS recombinant protein
 Disease Name  Pubmed Publications
 Pseudopseudohypoparathyroidism Antibodies  >200 publications with GNAS and Pseudopseudohypoparathyroidism
 PSEUDOHYPOPARATHYROIDISM, TYPE IA Antibodies  >200 publications with GNAS and PSEUDOHYPOPARATHYROIDISM, TYPE IA
 Pseudohypoparathyroidism Antibodies  >200 publications with GNAS and Pseudohypoparathyroidism
 Endocrine System Diseases Antibodies  >172 publications with GNAS and Endocrine System Diseases
 Fibrous Dysplasia, Polyostotic Antibodies  >109 publications with GNAS and Fibrous Dysplasia, Polyostotic
 Obesity Antibodies  >66 publications with GNAS and Obesity
 Kidney Diseases Antibodies  >35 publications with GNAS and Kidney Diseases
 Ossification, Heterotopic Antibodies  >32 publications with GNAS and Ossification, Heterotopic
 Hyperplasia Antibodies  >28 publications with GNAS and Hyperplasia
 Brachydactyly Antibodies  >28 publications with GNAS and Brachydactyly
 Organ/Tissue Name  Pubmed Publications
 Bone Antibodies  >159 publications with GNAS and Bone
 Blood Antibodies  >140 publications with GNAS and Blood
 Parathyroid Antibodies  >101 publications with GNAS and Parathyroid
 Thyroid Antibodies  >63 publications with GNAS and Thyroid
 Skin Antibodies  >62 publications with GNAS and Skin
 Nerve Antibodies  >57 publications with GNAS and Nerve
 Kidney Antibodies  >55 publications with GNAS and Kidney
 Brain Antibodies  >53 publications with GNAS and Brain
 Pancreas Antibodies  >51 publications with GNAS and Pancreas
 Muscle Antibodies  >34 publications with GNAS and Muscle
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