NP_062005.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
122,887 Da
NCBI Official Full Name
GNAS isoform GNASL
NCBI Official Synonym Full Names
GNAS complex locus
NCBI Official Synonym Symbols
ALEX; SCG6; Gnas1; Gnpas; Nesp55; G-alpha-8 [Similar Products]
NCBI Protein Information
ALEX; GNAS; SCG6 (secretogranin VI)
UniProt Protein Name
Guanine nucleotide-binding protein G(s) subunit alpha isoforms short
UniProt Synonym Protein Names
Adenylate cyclase-stimulating G alpha protein; G-alpha-8
UniProt Synonym Gene Names
NCBI Summary for Gnas
This locus has a highly complex imprinted expression pattern. It gives rise to maternally, paternally, and biallelically expressed transcripts that are derived from four alternative promoters and 5' exons. Some transcripts contain a differentially methylated region (DMR) at their 5' exons, and this DMR is commonly found in imprinted genes and correlates with transcript expression. In addition, one of the transcripts contains a second overlapping ORF, which encodes a structurally unrelated protein - Alex. Alternative splicing of downstream exons is also observed, which results in different forms of the stimulatory G-protein alpha subunit, a key element of the classical signal transduction pathway linking receptor-ligand interactions with the activation of adenylyl cyclase and a variety of cellular reponses. Multiple transcript variants have been found for this gene. [provided by RefSeq, Apr 2009]
UniProt Comments for Gnas
Guanine nucleotide-binding proteins (G proteins) function as transducers in numerous signaling pathways controlled by G protein-coupled receptors (GPCRs). Signaling involves the activation of adenylyl cyclases, resulting in increased levels of the signaling molecule cAMP. GNAS functions downstream of several GPCRs, including beta-adrenergic receptors. Stimulates the Ras signaling pathway via RAPGEF2.
Research Articles on Gnas
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Pathways associated with Gnas recombinant protein
Diseases associated with Gnas recombinant protein
Organs/Tissues associated with Gnas recombinant protein
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