Antibody Protein ELISA Kit from MyBioSource header Telephone 1.858.633.0165          
1.855.MyBioSource
Fax 1.858.633.0166    Email sales@mybiosource.com 
tel/fax
menu1 Home Products Ordering Company Help menu7
bottom
   MyBioSource rightarrow Recombinant Protein rightarrow Dkc1  rightarrow LOG IN  rightarrow MY ACCOUNT  rightarrow CART CONTENTS  rightarrow CHECKOUT 
horiz bar
MyBioSource Menu separator
separator
ELISA Kit ELISA Kit
CLIA Kit CLIA Kit
PCR Kit PCR Kit
Monoclonal Antibody Monoclonal Antibody
Polyclonal Antibody Polyclonal Antibody
Secondary Antibody Secondary Antibody
Antigen Antigen
Biochemical Biochemical
cDNA Clone cDNA Clone
siRNA siRNA
Peptide Peptide
Recombinant/Purified Protein Rec./Purified Protein

Custom ELISA Kit Custom ELISA Kit
Custom Protein Custom Protein
Custom Antibody Custom Antibody
Antibody Matched Pairs Antibody Matched Pairs
Antibody & Corresponding Blocking Peptide Pairs Antibody Peptide Pairs
Phospho-Specific Antibodies Phospho Antibodies
Products by Disease Products by Disease
Products by Pathway Products by Pathway
Products by Tissue Products by Tissue

arrow Advanced Search
arrow Submit Technical Q&A
arrow International Distributors
arrow Contact Us
separator
Our Best Sellers moreseparator
separator
 • CD18 Antibody
 • Insulin Regulated Aminopeptidase (LNPEP) Antibody
 • SNAI1 Antibody
 • SEMA7A ELISA Kit
 • klotho ELISA Kit
 • TNFRSF10C cDNA Clone
 • Transforming Growth Factor Beta 3 (TGFb3) ELISA Kit
 • Acylglycerol kinase (AGK) Peptide
 • EGF Antibody
 • NTRK1 - TRKA - TRK A Antibody
 • CD83 Antibody
 • SYK ELISA Kit
 • Cross Linked C-Telopeptide Of Type I Collagen (CTXI) Antibody
 • BUP mAb1 Antibody
 downarrow more ...
separator
separator
DatasheetFull DatasheetPrinter Friendly DatasheetPrint This DatasheetAdd to Compare ListHave Questions? Ask UsRequest for a Quotation today

Dkc1 recombinant protein :: H/ACA ribonucleoprotein complex subunit 4 (Dkc1) Recombinant Protein

Scan QR to view Datasheet Catalog #    MBS1454122 Dkc1 recombinant protein
Unit / Price
0.05 mg (E-Coli)  /  $930 +1 FREE 8GB USB
0.05 mg (Baculovirus)  /  $1,135 +1 FREE 8GB USB
0.2 mg (E-Coli)  /  $1,245 +1 FREE 8GB USB
0.2 mg (Yeast)  /  $1,360 +1 FREE 8GB USB
0.5 mg (E-Coli)  /  $1,375 +1 FREE 8GB USB
0.05 mg (Mammalian-Cell)  /  $1,385 +1 FREE 8GB USB
0.1 mg (Baculovirus)  /  $1,440 +1 FREE 8GB USB
0.5 mg (Yeast)  /  $1,540 +1 FREE 8GB USB
1 mg (E-Coli)  /  $1,955 +2 FREE 8GB USB
0.5 mg (Baculovirus)  /  $2,060 +2 FREE 8GB USB
0.1 mg (Mammalian-Cell)  /  $2,085 +2 FREE 8GB USB
1 mg (Yeast)  /  $2,340 +2 FREE 8GB USB
1 mg (Baculovirus)  /  $2,710 +3 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

H/ACA ribonucleoprotein complex subunit 4 (Dkc1), Recombinant Protein

 Also Known As   

Recombinant Mouse H/ACA ribonucleoprotein complex subunit 4 (Dkc1)

 Product Gene Name   

Dkc1 recombinant protein

[Similar Products]
 Product Synonym Gene Name    Dkc1 [Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
Table BarTOPTable Bar
 Sequence Positions    2-509aa, Full Length of Mature Protein
 Sequence    ADAEVITFPK KHKKKKDRKP LQEDDVAEIQ HAEEFLIKPE SKVAQLDTSQ WPLLLKNFDK LNVRTAHYTP LPCGSNPLKR EIGDYIRTGF INLDKPSNPS SHEVVAWIRR ILRVEKTGHS GTLDPKVTGC LIVCIERATR LVKSQQSAGK EYVGIVRLHN AIEGGTQLSR ALETLTGALF QRPPLIAAVK RQLRVRTIYE SKMIEYDPER RLGIFWVSCE AGTYIRTLCV HLGLLLGVGG QMQELRRVRS GVMSEKDHMV TMHDVLDAQW LYDNHKDESY LRRVVYPLEK LLTSHKRLVM KDSAVNAICY GAKIMLPGLL RYEDGIEVNQ EIVVITTKGE AICMAIALMT TAVISTCDHG IVAKIKRVIM ERDTYPRKWG LGPKASQKKM MIKQGLLDKH GKPTDNTPAT WKQDYIDYSD SGKNTLVTEA VQAPQLAAEA VNVIKRKRDS ESESDETPTV PQLKEKKKKK DKKPKTVLES GGETGDGDND TTKKKKKKKV KVVEEMSE
 3D Structure    ModBase 3D Structure for Q9ESX5
Section Bar
 Host    E Coli or Yeast or Baculovirus or Mammalian Cell
Section Bar
 Purity/Purification    >85% (SDS-PAGE) (lot specific)
 Form/Format    Liquid containing glycerol
 Tag Information    This protein contains an N-terminal tag and may also contain a C-terminal tag. Tag types are determined by various factors including tag-protein stability, please inquire for tag information.
 Sterility    Sterile filter available upon request.
 Endotoxin    Low endotoxin available upon request.
Section Bar
 Species    Mouse
 Storage Buffer    Tris-based buffer, 50% glycerol
 Tag Information    Tag type will be determined during the manufacturing process
Section Bar
 Preparation and Storage    Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.
 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Other Notes    Small volumes of Dkc1 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Table BarTOPTable Bar
 

Related Product Information for Dkc1 recombinant protein

   This gene is a member of the H
ACA snoRNPs (small nucleolar ribonucleoproteins) gene family. snoRNPs are involved in various aspects of rRNA processing and modification and have been classified into two families: C
D and H
ACA. The H
ACA snoRNPs also include the NOLA1, 2 and 3 proteins. This protein and the three NOLA proteins localize to the dense fibrillar components of nucleoli and to coiled (Cajal) bodies in the nucleus. Both 18S rRNA production and rRNA pseudouridylation are impaired if any one of the four proteins is depleted. These four H
ACA snoRNP proteins are also components of the telomerase complex. This protein is related to the Saccharomyces cerevisiae Cbf5p and Drosophila melanogaster Nop60B proteins. The gene lies in a tail-to-tail orientation with the palmitoylated erythrocyte membrane protein gene and is transcribed in a telomere to centromere direction. Both nucleotide substitutions and single trinucleotide repeat polymorphisms have been found in this gene. Mutations in this gene cause X-linked dyskeratosis congenita, a disease resulting in reticulate skin pigmentation, mucosal leukoplakia, nail dystrophy, and progressive bone marrow failure in most cases. Mutations in this gene also cause Hoyeraal-Hreidarsson syndrome, which is a more severe form of dyskeratosis congenita. Two transcript variants encoding different isoforms have been found for this gene.
NCBI/Uniprot data below describe general gene information for Dkc1. It may not necessarily be applicable to this product.
 NCBI GI #    91064867
 NCBI GeneID    245474
 NCBI Accession #    NP_001025478.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_001030307.2 [Other Products]
Section Bar
 UniProt Primary Accession #    Q9ESX5 [Other Products]
 UniProt Secondary Accession #    Q3UWE5 [Other Products]
 UniProt Related Accession #    Q9ESX5 [Other Products]
 Molecular Weight    57,402 Da
Table BarTOPTable Bar
 NCBI Official Full Name    H/ACA ribonucleoprotein complex subunit 4 isoform 3
 NCBI Official Synonym Full Names    dyskeratosis congenita 1, dyskerin
 NCBI Official Symbol    Dkc1 [Similar Products]
 NCBI Official Synonym Symbols   
BC068171
[Similar Products]
 NCBI Protein Information    H/ACA ribonucleoprotein complex subunit 4
 UniProt Protein Name    H/ACA ribonucleoprotein complex subunit 4
 UniProt Synonym Protein Names   
Dyskerin; Nopp140-associated protein of 57 kDa; Nucleolar protein NAP57; Nucleolar protein family A member 4; snoRNP protein DKC1
 UniProt Gene Name    Dkc1 [Similar Products]
Section Bar
 UniProt Comments for Dkc1    Required for ribosome biogenesis and telomere maintenance. Probable catalytic subunit of H/ACA small nucleolar ribonucleoprotein (H/ACA snoRNP) complex, which catalyzes pseudouridylation of rRNA. This involves the isomerization of uridine such that the ribose is subsequently attached to C5, instead of the normal N1. Each rRNA can contain up to 100 pseudouridine ('psi') residues, which may serve to stabilize the conformation of rRNAs. Also required for correct processing or intranuclear trafficking of TERC, the RNA component of the telomerase reverse transcriptase (TERT) holoenzyme.
Table BarTOPTable Bar
 Research Articles on Dkc1    1. Mouse embryonic fibroblasts cells with no pseudouridylation activity in H/ACA snoRNPs due to lack of Dkc1, can produce mature ribosomes, however, the ribosomes are very unstable and cell growth and division is very slow.
Table BarTOPTable Bar
 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
Table BarTOPTable Bar
Pathways associated with Dkc1 recombinant proteinDiseases associated with Dkc1 recombinant protein
 Products by Pathway  Pathway Diagram
 Cell Cycle Pathway antibodies  Cell Cycle Pathway Diagram
 Chromosome Maintenance Pathway antibodies  Chromosome Maintenance Pathway Diagram
 Extension Of Telomeres Pathway antibodies  Extension Of Telomeres Pathway Diagram
 H/ACA Ribonucleoprotein Complex Pathway antibodies  H/ACA Ribonucleoprotein Complex Pathway Diagram
 Ribosome Biogenesis In Eukaryotes Pathway antibodies  Ribosome Biogenesis In Eukaryotes Pathway Diagram
 Ribosome Biogenesis In Eukaryotes Pathway antibodies  Ribosome Biogenesis In Eukaryotes Pathway Diagram
 Telomere Extension By Telomerase Pathway antibodies  Telomere Extension By Telomerase Pathway Diagram
 Telomere Maintenance Pathway antibodies  Telomere Maintenance Pathway Diagram
 Disease Name  Pubmed Publications
 DYSKERATOSIS CONGENITA, X-LINKED Antibodies  >133 publications with Dkc1 and DYSKERATOSIS CONGENITA, X-LINKED
 Dyskeratosis Congenita Antibodies  >133 publications with Dkc1 and Dyskeratosis Congenita
 Congenital Abnormalities Antibodies  >117 publications with Dkc1 and Congenital Abnormalities
 Anemia Antibodies  >31 publications with Dkc1 and Anemia
 Bone Marrow Diseases Antibodies  >28 publications with Dkc1 and Bone Marrow Diseases
 Neoplasms Antibodies  >27 publications with Dkc1 and Neoplasms
 Hoyeraal Hreidarsson syndrome Antibodies  >16 publications with Dkc1 and Hoyeraal Hreidarsson syndrome
 Nervous System Diseases Antibodies  >11 publications with Dkc1 and Nervous System Diseases
 Fibrosis Antibodies  >9 publications with Dkc1 and Fibrosis
 Carcinoma Antibodies  >7 publications with Dkc1 and Carcinoma
Organs/Tissues associated with Dkc1 recombinant protein
 Organ/Tissue Name  Pubmed Publications
 Bone Marrow Antibodies  >76 publications with Dkc1 and Bone Marrow
 Skin Antibodies  >27 publications with Dkc1 and Skin
 Blood Antibodies  >24 publications with Dkc1 and Blood
 Brain Antibodies  >9 publications with Dkc1 and Brain
 Lung Antibodies  >7 publications with Dkc1 and Lung
 Liver Antibodies  >7 publications with Dkc1 and Liver
 Embryonic Tissue Antibodies  >5 publications with Dkc1 and Embryonic Tissue
 Prostate Antibodies  >3 publications with Dkc1 and Prostate
 Heart Antibodies  >3 publications with Dkc1 and Heart
 Intestine Antibodies  >2 publications with Dkc1 and Intestine
Table BarTOPTable Bar
horiz bar
 SSL   Follow us on Facebook Follow us onTwitter Follow us on Google Plus Connect us on LinkedIn Subscribe to our RSS Feed for latest products and special promotions