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CLCN3 recombinant protein :: H (+)/Cl (-) exchange transporter 3 (CLCN3) Recombinant Protein

Scan QR to view Datasheet Catalog #    MBS1142109 CLCN3 recombinant protein
Unit / Price
1 mg (E-Coli)  /  $2,790 +3 FREE 8GB USB
1 mg (Yeast)  /  $3,250 +4 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

H (+)/Cl (-) exchange transporter 3 (CLCN3), Recombinant Protein

 Also Known As   

Recombinant Rabbit H (+)/Cl (-) exchange transporter 3 (CLCN3)

 Product Synonym Names    Recombinant H (+)/Cl (-) exchange transporter 3 (CLCN3); H(+)/Cl(-) exchange transporter 3; Chloride channel protein 3; ClC-3 Chloride transporter ClC-3
 Product Gene Name   

CLCN3 recombinant protein

[Similar Products]
 Product Synonym Gene Name    CLCN3 [Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Sequence Positions    1-818
 Sequence    MESEQLFHRG YYRNSYNSIT SASSDEELLD GAGVIMDFQT SEDDNLLDGD TAVGTHYTMT NGGSINSSTH LLDLLDEPIP GVGTYDDFHT IDWVREKCKD RERHRRINSK KKESAWEMTK SLYDAWSGWL VVTLTGLASG ALAGLIDIAA DWMTDLKEGI CLSALWYNHE QCCWGSNETT FEERDKCPQW KTWAELIIGQ AEGPGSYIMN YIMYIFWALS FAFLAVSLVK VFAPYACGSG IPEIKTILSG FIIRGYLGKW TLMIKTITLV LAVASGLSLG KEGPLVHVAC CCGNIFSYLF PKYSTNEAKK REVLSAASAA GVSVAFGAPI GGVLFSLEEV SYYFPLKTLW RSFFAALVAA FVLRSINPFG NSRLVLFYVE YHTPWYLFEL FPFILLGVFG GLWGAFFIRA NIAWCRRRKS TKFGKYPVLE VIIVAAITAV IAFPNPYTRL NTSELIKELF TDCGPLESSS LCDYRNDMNA SKIVDDIPDR PAGIGVYSAI WQLCLALIFK IIMTVFTFGI KVPSGLFIPS MAIGAIAGRI VGIAVEQLAY YHHDWFIFKE WCEVGADCIT PGLYAMVGAA ACLGGVTRMT VSLVVIVFEL TGGLEYIVPL MAAVMTSKWV GDAFGREGIY EAHIRLNGYP FLDAKEEFTH TTLAADVMRP RRNDPPLAVL TQDNMTVDDI ENMINETSYN GFPVIMSKES QRLVGFALRR DLTIAIESAR KKQEGIVGSS RVCFAQHTPS LPAESPRPLK LRSILDMSPF TVTDHTPMEI VVDIFRKLGL RQCLVTHNGR LLGIITKKDI LRHMAQTANQ DPASIMFN
 Chromosome Location    Chromosome: 2; NC_013670.1 (47703241..47779719). Location: chromosome: 2
 3D Structure    ModBase 3D Structure for O18894
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 Host    E Coli or Yeast or Baculovirus or Mammalian Cell
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 Purity/Purification    >90%
 Form/Format    Liquid containing glycerol; lyophilization may be available upon request.
 Tag Information    This protein contains an N-terminal tag and may also contain a C-terminal Myc-tag. N-terminal host tags may vary (His, His-SUMO, His-B2M, GST). Tag types are determined by various factors including tag-protein stability and, therefore, are subject to change; please inquire for tag information. Additional charge for Tag removal. Tag removal service standardly refers to removal of N-terminal Tag. Any C-terminal Myc-tag may remain intact unless removal of the C-terminal Myc-tag is specifically requested. In most cases tags can be successfully removed. If the lab concludes the protein is no longer stable after tag removal then your protein will be supplied with the tag intact, and you will not be charged for tag removal service.
 Sterility    Sterile filter available upon request.
 Endotoxin    Low endotoxin available upon request.
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 Species    Oryctolagus cuniculus (Rabbit)
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 Preparation and Storage    Store at -20 degree C. For extended storage, store at -20 or -80 degree C.
 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Other Notes    Small volumes of CLCN3 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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NCBI/Uniprot data below describe general gene information for CLCN3. It may not necessarily be applicable to this product.
 NCBI GI #    126723586
 NCBI GeneID    100008673
 NCBI Accession #    NP_001075498.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_001082029.1 [Other Products]
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 UniProt Primary Accession #    O18894 [Other Products]
 UniProt Related Accession #    O18894 [Other Products]
 Molecular Weight    90,966 Da [Similar Products]
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 NCBI Official Full Name    H(+)/Cl(-) exchange transporter 3
 NCBI Official Symbol    CLCN3 [Similar Products]
 NCBI Protein Information    H(+)/Cl(-) exchange transporter 3; H(+)/Cl(-) exchange transporter 3; clC-3; chloride channel 3; chloride channel protein 3; chloride transporter ClC-3
 UniProt Protein Name    H(+)/Cl(-) exchange transporter 3
 UniProt Synonym Protein Names   
Chloride channel protein 3; ClC-3; Chloride transporter ClC-3
 Protein Family    H(+)/Cl(-) exchange transporter
 UniProt Gene Name    CLCN3 [Similar Products]
 UniProt Synonym Gene Names    ClC-3 [Similar Products]
 UniProt Entry Name    CLCN3_RABIT
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 UniProt Comments for CLCN3    Function: Mediates the exchange of chloride ions against protons. Functions as antiporter and contributes to the acidification of the endosome and synaptic vesicle lumen, and may thereby affect vesicle trafficking and exocytosis. May play an important role in neuronal cell function through regulation of membrane excitability by protein kinase C. It could help neuronal cells to establish short-term memory

By similarity.

Subcellular location: Early endosome membrane; Multi-pass membrane protein

By similarity. Late endosome membrane; Multi-pass membrane protein

By similarity. Cytoplasmic vesicle › secretory vesicle membrane; Multi-pass membrane protein

By similarity.

Post-translational modification: N-glycosylated

By similarity.

Miscellaneous: The CLC channel family contains both chloride channels and proton-coupled anion transporters that exchange chloride or another anion for protons. The presence of conserved gating glutamate residues is typical for family members that function as antiporters

By similarity.

Sequence similarities: Belongs to the chloride channel (TC 2.A.49) family. ClC-3/CLCN3 subfamily. [View classification]Contains 2 CBS domains.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Diseases associated with CLCN3 recombinant proteinOrgans/Tissues associated with CLCN3 recombinant protein
 Disease Name  Pubmed Publications
 Nervous System Diseases Antibodies  >5 publications with CLCN3 and Nervous System Diseases
 Heart Failure Antibodies  >2 publications with CLCN3 and Heart Failure
 Heart Diseases Antibodies  >2 publications with CLCN3 and Heart Diseases
 Kidney Diseases Antibodies  >2 publications with CLCN3 and Kidney Diseases
 Proteinuria Antibodies  >2 publications with CLCN3 and Proteinuria
 Myocardial Ischemia Antibodies  >1 publications with CLCN3 and Myocardial Ischemia
 Fibrosis Antibodies  >1 publications with CLCN3 and Fibrosis
 Neoplasms Antibodies  >1 publications with CLCN3 and Neoplasms
 Muscular Diseases Antibodies  >1 publications with CLCN3 and Muscular Diseases
 Cardiomyopathies Antibodies  >1 publications with CLCN3 and Cardiomyopathies
 Organ/Tissue Name  Pubmed Publications
 Central Nervous System Antibodies  >7 publications with CLCN3 and Central Nervous System
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