NP_000075.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
90,785 Da
NCBI Official Full Name
H(+)/Cl(-) exchange transporter 5 isoform b
NCBI Official Synonym Full Names
chloride voltage-gated channel 5
NCBI Official Synonym Symbols
XRN; CLC5; XLRH; CLCK2; ClC-5; DENTS; NPHL1; NPHL2; hCIC-K2 [Similar Products]
NCBI Protein Information
H(+)/Cl(-) exchange transporter 5
UniProt Protein Name
H(+)/Cl(-) exchange transporter 5
UniProt Synonym Protein Names
Chloride channel protein 5; ClC-5; Chloride transporter ClC-5
UniProt Synonym Gene Names
NCBI Summary for CLCN5
This gene encodes a member of the ClC family of chloride ion channels and ion transporters. The encoded protein is primarily localized to endosomal membranes and may function to facilitate albumin uptake by the renal proximal tubule. Mutations in this gene have been found in Dent disease and renal tubular disorders complicated by nephrolithiasis. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jan 2013]
UniProt Comments for CLCN5
Proton-coupled chloride transporter. Functions as antiport system and exchanges chloride ions against protons. Important for normal acidification of the endosome lumen. May play an important role in renal tubular function.
Research Articles on CLCN5
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Products associated with CLCN5 recombinant protein
Pathways associated with CLCN5 recombinant protein
Diseases associated with CLCN5 recombinant protein
Organs/Tissues associated with CLCN5 recombinant protein
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