NP_001107803.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
86,026 Da
NCBI Official Full Name
H(+)/Cl(-) exchange transporter 7 isoform b
NCBI Official Synonym Full Names
chloride voltage-gated channel 7
NCBI Official Synonym Symbols
CLC7; CLC-7; OPTA2; OPTB4; PPP1R63 [Similar Products]
NCBI Protein Information
H(+)/Cl(-) exchange transporter 7
UniProt Protein Name
H(+)/Cl(-) exchange transporter 7
UniProt Synonym Protein Names
Chloride channel 7 alpha subunit; Chloride channel protein 7; ClC-7
UniProt Synonym Gene Names
NCBI Summary for CLCN7
The product of this gene belongs to the CLC chloride channel family of proteins. Chloride channels play important roles in the plasma membrane and in intracellular organelles. This gene encodes chloride channel 7. Defects in this gene are the cause of osteopetrosis autosomal recessive type 4 (OPTB4), also called infantile malignant osteopetrosis type 2 as well as the cause of autosomal dominant osteopetrosis type 2 (OPTA2), also called autosomal dominant Albers-Schonberg disease or marble disease autosoml dominant. Osteopetrosis is a rare genetic disease characterized by abnormally dense bone, due to defective resorption of immature bone. OPTA2 is the most common form of osteopetrosis, occurring in adolescence or adulthood. [provided by RefSeq, Jul 2008]
UniProt Comments for CLCN7
Slowly voltage-gated channel mediating the exchange of chloride ions against protons. Functions as antiporter and contributes to the acidification of the lysosome lumen.
Research Articles on CLCN7
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Products associated with CLCN7 recombinant protein
Pathways associated with CLCN7 recombinant protein
Diseases associated with CLCN7 recombinant protein
Organs/Tissues associated with CLCN7 recombinant protein
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