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HAGH recombinant protein

Scan QR to view Datasheet Catalog #    MBS203809
SDS-PAGE
Unit / Price
0.05 mg  /  $375 +1 FREE 8GB USB
0.25 mg  /  $925 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

HAGH, Recombinant Protein

 Also Known As   

HAGH, 1-260aa, Human, His tag, E Coli

 Product Synonym Names    Hydroxyacylglutathione hydrolase; GLO; GLX2; Glyoxalase II; HAGH1
 Product Gene Name   

HAGH recombinant protein

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Sequence    MGSSHHHHHH SSGLVPRGSH MGSHMKVEVL PALTDNYMYL VIDDETKEAA IVDPVQPQKV VDAARKHGVK LTTVLTTHHH WDHAGGNEKL VKLESGLKVY GGDDRIGALT HKITHLSTLQ VGSLNVKCLA TPCHTSGHIC YFVSKPGGSE PPAVFTGDTL FVAGCGKFYE GTADEMCKAL LEVLGRLPPD TRVYCGHEYT INNLKFARHV EPGNAAIREK LAWAKEKYSI GEPTVPSTLA EEFTYNPFMR VREKTVQQHA GETDPVTTMR AVRREKDQFK MPRD
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 Purity/Purification    > 95% by SDS - PAGE
 Form/Format    Liquid. In 20 mM Tris-HCl Buffer (pH 8.5) containing 10% Glycerol
 Concentration    0.5 mg/ml (determined by Bradford assay) (lot specific)
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 Antigen Species    Human
 Tag    His-tag
 Expression System    E Coli
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 Preparation and Storage    Can be stored at 4 degree C short term (1-2 weeks). For long term storage, aliquot and store at -20 degree C or -70 degree C. Avoid repeated freezing and thawing cycles.
 Other Notes    Small volumes of HAGH recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Product Description specifically for HAGH recombinant protein

   HAGH is a member of the glyoxalase family and a thiolesterase which hydrolyses S-lactoyl-glutathione to reduced glutathione and D-lactate. This protein is a detoxifying enzyme of glycolysis byproduct methylglyoxal and a target of p63 and p73 and serves as a pro-survival factor of the p53 family. It exists only as a monomer and binds two zinc ions per subunit. Recombinant human HAGH protein, fused to His-tag at N-terminus, was expressed in E.coli and purified by using conventional chromatography.
 Product Categories/Family for HAGH recombinant protein    Enzymes & Proteases
 Applications Tested/Suitable for HAGH recombinant protein   

SDS-PAGE

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 SDS-PAGE of HAGH recombinant protein    HAGH recombinant protein SDS-PAGE image
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NCBI/Uniprot data below describe general gene information for HAGH. It may not necessarily be applicable to this product.
 NCBI GI #    94538320
 NCBI GeneID    3029
 NCBI Accession #    NP_001035517 [Other Products]
 NCBI GenBank Nucleotide #    NM_001040427.1 [Other Products]
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 UniProt Secondary Accession #    A8K290; B4DP33; B4DRA7; E7EN93 [Other Products]
 UniProt Related Accession #    Q16775 [Other Products]
 Molecular Weight    31.4 kDa (284aa), confirmed by MALDI-TOF
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 NCBI Official Full Name    hydroxyacylglutathione hydrolase, mitochondrial isoform 2
 NCBI Official Synonym Full Names    hydroxyacylglutathione hydrolase
 NCBI Official Symbol    HAGH [Similar Products]
 NCBI Official Synonym Symbols   
GLO2; GLX2; GLXII; HAGH1
[Similar Products]
 NCBI Protein Information    hydroxyacylglutathione hydrolase, mitochondrial; glx II; glyoxalase II; hydroxyacylglutathione hydroxylase
 UniProt Protein Name    Hydroxyacylglutathione hydrolase, mitochondrial
 UniProt Synonym Protein Names   
Glyoxalase II; Glx II
 UniProt Gene Name    HAGH [Similar Products]
 UniProt Synonym Gene Names    GLO2; HAGH1; Glx II [Similar Products]
 UniProt Entry Name    GLO2_HUMAN
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 NCBI Summary for HAGH    The enzyme encoded by this gene is classified as a thiolesterase and is responsible for the hydrolysis of S-lactoyl-glutathione to reduced glutathione and D-lactate. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2013]
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 UniProt Comments for HAGH    HAGH: Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid. Belongs to the metallo-beta-lactamase superfamily. Glyoxalase II family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Mitochondrial; EC 3.1.2.6; Carbohydrate Metabolism - pyruvate; Hydrolase

Chromosomal Location of Human Ortholog: 16p13.3

Cellular Component: mitochondrial matrix; cytoplasm

Molecular Function: hydroxyacylglutathione hydrolase activity; zinc ion binding

Biological Process: glutathione biosynthetic process

Disease: Hydroxyacyl Glutathione Hydrolase Deficiency
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Product References and Citations for HAGH recombinant protein

   Vila AJ., et al. (2010) J Inorg Biochem. 104(7):726-31.
Crowder MW., et al (2009) Biochemistry. 48(23):5426-34.
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 Research Articles on HAGH    1. Observational study of gene-disease association. (HuGE Navigator)
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with HAGH recombinant proteinPathways associated with HAGH recombinant protein
 Reference Product  PubMed Publications
 PGP recombinant protein  >4 publications with HAGH and PGP
 GLO1 recombinant protein  >4 publications with HAGH and GLO1
 ESD recombinant protein  >1 publications with HAGH and ESD
 Products by Pathway  Pathway Diagram
 Pyruvate Metabolism Pathway antibodies  Pyruvate Metabolism Pathway Diagram
 Pyruvate Metabolism Pathway antibodies  Pyruvate Metabolism Pathway Diagram
Diseases associated with HAGH recombinant proteinOrgans/Tissues associated with HAGH recombinant protein
 Disease Name  Pubmed Publications
 Nervous System Diseases Antibodies  >4 publications with HAGH and Nervous System Diseases
 Congenital Abnormalities Antibodies  >2 publications with HAGH and Congenital Abnormalities
 Heart Defects, Congenital Antibodies  >1 publications with HAGH and Heart Defects, Congenital
 Heart Diseases Antibodies  >1 publications with HAGH and Heart Diseases
 Kidney Diseases Antibodies  >1 publications with HAGH and Kidney Diseases
 Inflammation Antibodies  >1 publications with HAGH and Inflammation
 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >5 publications with HAGH and Brain
 Kidney Antibodies  >3 publications with HAGH and Kidney
 Skin Antibodies  >2 publications with HAGH and Skin
 Heart Antibodies  >2 publications with HAGH and Heart
 Blood Antibodies  >2 publications with HAGH and Blood
 Nerve Antibodies  >1 publications with HAGH and Nerve
 Muscle Antibodies  >1 publications with HAGH and Muscle
 Lung Antibodies  >1 publications with HAGH and Lung
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