NP_000508
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
19.5 kDa (179aa)
NCBI Official Full Name
hemoglobin subunit alpha
NCBI Official Synonym Full Names
hemoglobin subunit alpha 2
NCBI Official Synonym Symbols
NCBI Protein Information
hemoglobin subunit alpha
UniProt Protein Name
Hemoglobin subunit alpha
UniProt Synonym Protein Names
Alpha-globin; Hemoglobin alpha chain
NCBI Summary for HBA2
The human alpha globin gene cluster located on chromosome 16 spans about 30 kb and includes seven loci: 5'- zeta - pseudozeta - mu - pseudoalpha-1 - alpha-2 - alpha-1 - theta - 3'. The alpha-2 (HBA2) and alpha-1 (HBA1) coding sequences are identical. These genes differ slightly over the 5' untranslated regions and the introns, but they differ significantly over the 3' untranslated regions. Two alpha chains plus two beta chains constitute HbA, which in normal adult life comprises about 97% of the total hemoglobin; alpha chains combine with delta chains to constitute HbA-2, which with HbF (fetal hemoglobin) makes up the remaining 3% of adult hemoglobin. Alpha thalassemias result from deletions of each of the alpha genes as well as deletions of both HBA2 and HBA1; some nondeletion alpha thalassemias have also been reported. [provided by RefSeq, Jul 2008]
UniProt Comments for HBA2
Involved in oxygen transport from the lung to the various peripheral tissues.
Product References and Citations for HBA2 recombinant protein
Jorge S.B., et al. (2003) Braz. J. Med. Biol. Res. 36:1471-1474; Abdulmalik O., et al. (2004) Am. J. Hematol. 77:268-276
Research Articles on HBA2
Precautions
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Products associated with HBA2 recombinant protein
Pathways associated with HBA2 recombinant protein
Diseases associated with HBA2 recombinant protein
Organs/Tissues associated with HBA2 recombinant protein
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