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HER3 / ErbB3 recombinant protein

Scan QR to view Datasheet Catalog #    MBS2546418
SDS-PAGE
Unit / Price
0.01 mg  /  $525 +1 FREE 8GB USB
0.02 mg  /  $905 +1 FREE 8GB USB
 
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 Product Name   

HER3 / ErbB3, Recombinant Protein

★Popular Item★
 Also Known As   

Recombinant Human HER3 / ErbB3 Protein (His tag)

 Product Synonym Names    HER3, LCCS2, ErbB-3, c-erbB3, erbB3-S, MDA-BF-1, MGC88033, c-erbB-3, p180-ErbB3, p45-sErbB3, p85-sErbB3
 Product Gene Name   

HER3 / ErbB3 recombinant protein

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    M29366 mRNA
 3D Structure    ModBase 3D Structure for P21860
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 Host    Human Cells
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 Purity/Purification    > 95 % as determined by SDS-PAGE
 Form/Format    Lyophilized from sterile PBS, pH 7.4, 5% trehalose, 5% mannitol, 0.01% Tween80.
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 Source    Human
 Predicted N Terminal    Ser 20
 Bio-Activity    1. Measured by its binding ability in a functional ELISA.
2. Immobilized human ErbB3 at 2 ug/mL (100 ul/well) can bind human NRG1 (isoform Beta1), The EC50 of human NRG1 (isoform Beta1) is 0.43 ug/mL.
 Endotoxin    < 1.0 EU per mug of the protein as determined by the LAL method
 Reconstitution    It is recommended that sterile water (70 ul) be added to the vial to prepare a stock solution of 0.15 mg/mL.
Concentration is measured by UV-Vis.
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 Preparation and Storage    Store it under sterile conditions at -20 degree C to -80 degree C. It is recommended that the protein be aliquoted and be used as soon as possible. Avoid repeated freeze-thaw cycles.
 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Other Notes    Small volumes of HER3 / ErbB3 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for HER3 / ErbB3 recombinant protein

   Background: ErbB3, also known as Her3 (human epidermal growth factor receptor3), is a member of the epidermal growth factor receptor (EGFR) family of receptor tyrosine kinases. This membrane-bound glycoprotein has a neuregulin binding domain but has not an active kinase domain., and therefore can not mediate the intracellular signal transduction through protein phosphorylation. However, its heterodimer with ErbB2 or other EGFR members responsible for tyrosine phosphorylation forms a receptor complex with high affinity, and initiates the related pathway which lead to cell proliferation or differentiation. ErbB3 has been shown to implicated in numerous cancers, including prostate, bladder, and breast tumors. This protein has different isoforms derived from alternative splicing variants, and among which, the secreted isoform lacking the intermembrane region modulates the activity of membrane-bound form.

Description: A DNA sequence encoding the extracellular domain (Met 1-Thr 643) of human ErbB3 (NP_001973.2) precursor was expressed, with a C-terminal polyhistidine tag.
 Application Notes for HER3 / ErbB3 recombinant protein    The recombinant human ErbB3 protein consists of 635 amino acids after the removal of signal peptide and has a calculated molecular mass of 70.2 kDa. As a result of glycosylation, the recombinant ErbB3 migrates as an approximately 100-110 kDa band in SDS-PAGE under reducing conditions.
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 SDS-PAGE of HER3 / ErbB3 recombinant protein    HER3 / ErbB3 recombinant protein SDS-PAGE image
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NCBI/Uniprot data below describe general gene information for HER3 / ErbB3. It may not necessarily be applicable to this product.
 NCBI GI #    54792100
 NCBI GeneID    2065
 NCBI Accession #    NP_001973.2 [Other Products]
 NCBI GenBank Nucleotide #    NM_001982.3 [Other Products]
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 UniProt Primary Accession #    P21860 [Other Products]
 UniProt Secondary Accession #    Q9BUD7; A8K6L6; B4DIK7; B4DV32; E9PDT8 [Other Products]
 UniProt Related Accession #    P21860 [Other Products]
 Molecular Weight    77,426 Da
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 NCBI Official Full Name    receptor tyrosine-protein kinase erbB-3 isoform 1
 NCBI Official Synonym Full Names    erb-b2 receptor tyrosine kinase 3
 NCBI Official Symbol    ERBB3 [Similar Products]
 NCBI Official Synonym Symbols   
HER3; LCCS2; ErbB-3; c-erbB3; erbB3-S; MDA-BF-1; c-erbB-3; p180-ErbB3; p45-sErbB3; p85-sErbB3
[Similar Products]
 NCBI Protein Information    receptor tyrosine-protein kinase erbB-3
 UniProt Protein Name    Receptor tyrosine-protein kinase erbB-3
 UniProt Synonym Protein Names   
Proto-oncogene-like protein c-ErbB-3; Tyrosine kinase-type cell surface receptor HER3
 UniProt Gene Name    ERBB3 [Similar Products]
 UniProt Synonym Gene Names    HER3 [Similar Products]
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 NCBI Summary for HER3 / ErbB3    This gene encodes a member of the epidermal growth factor receptor (EGFR) family of receptor tyrosine kinases. This membrane-bound protein has a neuregulin binding domain but not an active kinase domain. It therefore can bind this ligand but not convey the signal into the cell through protein phosphorylation. However, it does form heterodimers with other EGF receptor family members which do have kinase activity. Heterodimerization leads to the activation of pathways which lead to cell proliferation or differentiation. Amplification of this gene and/or overexpression of its protein have been reported in numerous cancers, including prostate, bladder, and breast tumors. Alternate transcriptional splice variants encoding different isoforms have been characterized. One isoform lacks the intermembrane region and is secreted outside the cell. This form acts to modulate the activity of the membrane-bound form. Additional splice variants have also been reported, but they have not been thoroughly characterized. [provided by RefSeq, Jul 2008]
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 UniProt Comments for HER3 / ErbB3    HER3: a receptor tyrosine kinase of the EGFR family. Binds and is activated by neuregulins and NTAK. Can form homodimers or ErbB-2/ErbB-3 heterodimers. Kinase domain lacks activity but heterodimerizes with other EGFRs to transduce growth signals. May be required for HER2 activity. Elevated expression in breast and other tumors is indicative of poor outcome. A secreted form is expressed in metastatic prostate cancer Two alternatively spliced isoforms have been described.

Protein type: EC 2.7.10.1; EGFR family; Kinase, protein; Membrane protein, integral; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (receptor); TK group

Chromosomal Location of Human Ortholog: 12q13.2

Cellular Component: basolateral plasma membrane; extracellular space; integral to plasma membrane; plasma membrane; receptor complex

Molecular Function: growth factor binding; identical protein binding; phosphatidylinositol-4,5-bisphosphate 3-kinase activity; protein binding; protein heterodimerization activity; protein tyrosine kinase activator activity; protein-tyrosine kinase activity; Ras guanyl-nucleotide exchange factor activity; transmembrane receptor activity

Biological Process: cranial nerve development; heart development; MAPKKK cascade; negative regulation of cell adhesion; negative regulation of neuron apoptosis; negative regulation of secretion; negative regulation of signal transduction; neuron apoptosis; peripheral nervous system development; phosphoinositide 3-kinase cascade; phosphoinositide-mediated signaling; positive regulation of phosphoinositide 3-kinase cascade; regulation of cell proliferation; regulation of phosphoinositide 3-kinase cascade; Schwann cell differentiation; signal transduction; transmembrane receptor protein tyrosine kinase signaling pathway

Disease: Lethal Congenital Contracture Syndrome 2
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 Research Articles on HER3 / ErbB3    1. High HER3 expression in colon cancer was associated to distal colon location and low-grade tumor.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with HER3 / ErbB3 recombinant proteinPathways associated with HER3 / ErbB3 recombinant protein
 Reference Product  PubMed Publications
 ERBB2 recombinant protein  >821 publications with HER3 / ErbB3 and ERBB2
 EGFR recombinant protein  >425 publications with HER3 / ErbB3 and EGFR
 EGF recombinant protein  >276 publications with HER3 / ErbB3 and EGF
 NRG1 recombinant protein  >92 publications with HER3 / ErbB3 and NRG1
 PA2G4 recombinant protein  >34 publications with HER3 / ErbB3 and PA2G4
 GRB2 recombinant protein  >23 publications with HER3 / ErbB3 and GRB2
 NRG2 recombinant protein  >18 publications with HER3 / ErbB3 and NRG2
 RNF41 recombinant protein  >17 publications with HER3 / ErbB3 and RNF41
 SHC1 recombinant protein  >7 publications with HER3 / ErbB3 and SHC1
 Products by Pathway  Pathway Diagram
 Adaptive Immune System Pathway antibodies  Adaptive Immune System Pathway Diagram
 Calcium Signaling Pathway antibodies  Calcium Signaling Pathway Diagram
 Calcium Signaling Pathway antibodies  Calcium Signaling Pathway Diagram
 Constitutive PI3K/AKT Signaling In Cancer Pathway antibodies  Constitutive PI3K/AKT Signaling In Cancer Pathway Diagram
 DAP12 Interactions Pathway antibodies  DAP12 Interactions Pathway Diagram
 DAP12 Signaling Pathway antibodies  DAP12 Signaling Pathway Diagram
 Disease Pathway antibodies  Disease Pathway Diagram
 Downregulation Of ERBB2:ERBB3 Signaling Pathway antibodies  Downregulation Of ERBB2:ERBB3 Signaling Pathway Diagram
 Downstream Signal Transduction Pathway antibodies  Downstream Signal Transduction Pathway Diagram
 Downstream Signaling Events Of B Cell Receptor (BCR) Pathway antibodies  Downstream Signaling Events Of B Cell Receptor (BCR) Pathway Diagram
Diseases associated with HER3 / ErbB3 recombinant proteinOrgans/Tissues associated with HER3 / ErbB3 recombinant protein
 Disease Name  Pubmed Publications
 Breast Neoplasms Antibodies  >237 publications with HER3 / ErbB3 and Breast Neoplasms
 Carcinoma Antibodies  >225 publications with HER3 / ErbB3 and Carcinoma
 Adenocarcinoma Antibodies  >91 publications with HER3 / ErbB3 and Adenocarcinoma
 Lung Neoplasms Antibodies  >82 publications with HER3 / ErbB3 and Lung Neoplasms
 Neoplasms, Experimental Antibodies  >64 publications with HER3 / ErbB3 and Neoplasms, Experimental
 Nervous System Diseases Antibodies  >63 publications with HER3 / ErbB3 and Nervous System Diseases
 Disease Models, Animal Antibodies  >55 publications with HER3 / ErbB3 and Disease Models, Animal
 Neoplasm Metastasis Antibodies  >50 publications with HER3 / ErbB3 and Neoplasm Metastasis
 Prostatic Neoplasms Antibodies  >36 publications with HER3 / ErbB3 and Prostatic Neoplasms
 Ovarian Neoplasms Antibodies  >28 publications with HER3 / ErbB3 and Ovarian Neoplasms
 Organ/Tissue Name  Pubmed Publications
 Nerve Antibodies  >139 publications with HER3 / ErbB3 and Nerve
 Lung Antibodies  >115 publications with HER3 / ErbB3 and Lung
 Brain Antibodies  >78 publications with HER3 / ErbB3 and Brain
 Muscle Antibodies  >72 publications with HER3 / ErbB3 and Muscle
 Prostate Antibodies  >56 publications with HER3 / ErbB3 and Prostate
 Vascular Antibodies  >48 publications with HER3 / ErbB3 and Vascular
 Embryonic Tissue Antibodies  >44 publications with HER3 / ErbB3 and Embryonic Tissue
 Heart Antibodies  >43 publications with HER3 / ErbB3 and Heart
 Liver Antibodies  >36 publications with HER3 / ErbB3 and Liver
 Mammary Gland Antibodies  >34 publications with HER3 / ErbB3 and Mammary Gland
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