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HIF1AN recombinant protein

Scan QR to view Datasheet Catalog #    MBS203207
SDS-Page
Unit / Price
0.1 mg  /  $255 +1 FREE 8GB USB
0.5 mg  /  $535 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

HIF1AN, Recombinant Protein

 Also Known As   

HIF1AN, 1-349aa, Human, E Coli

 Product Synonym Names    Hypoxia-inducible factor 1 alpha subunit inhibitor; Hypoxia-inducible factor asparagine hydroxylase; Factor inhibiting HIF-1; FIH1; Hypoxia-inducible factor 1; alpha subunit inhibitor Hypoxia inducible factor asparagine hydroxylase; Factor inhibiting HIF1; FIH 1; FLJ20615; FLJ22027; Hypoxia inducible factor 1 alpha inhibitor; Hypoxia inducible factor 1 alpha subunit inhibitor; Peptide aspartate beta dioxygenase; DKFZp762F1811; Hypoxia-Inducible Factor-1 Alpha Inhibitor
 Product Gene Name   

HIF1AN recombinant protein

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Sequence    MAATAAEAVA SGSGEPREEA GALGPAWDES QLRSYSFPTR PIPRLSQSDP RAEELIENEE PVVLTDTNLV YPALKWDLEY LQENIGNGDF SVYSASTHKF LYYDEKKMAN FQNFKPRSNR EEMKFHEFVE KLQDIQQRGG EERLYLQQTL NDTVGRKIVM DFLGFNWNWI NKQQGKRGWG QLTSNLLLIG MEGNVTPAHY DEQQNFFAQI KGYKRCILFP PDQFECLYPY PVHHPCDRQS QVDFDNPDYE RFPNFQNVVG YETVVGPGDV LYIPMYWWHH IESLLNGGIT ITVNFWYKGA PTPKRIEYPL KAHQKVAIMR NIEKMLGEAL GNPQEVGPLL NTMIKGRYN
 OMIM    AF395830 mRNA
 3D Structure    ModBase 3D Structure for Q9NWT6
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 Host    E Coli
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 Purity/Purification    > 90% by SDS-PAGE
 Form/Format    Liquid. In 20 mM Tris-HCl Buffer (pH 8.0)
 Concentration    1 mg/ml (determined by Bradford assay) (lot specific)
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 Antigen Species    Human
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 Preparation and Storage    Can be stored at 4 degree C short term (1-2 weeks).
For long term storage, aliquot and store at -20 degree C or -70 degree C.
Avoid repeated freezing and thawing cycles.
 Other Notes    Small volumes of HIF1AN recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for HIF1AN recombinant protein

   Description: Hypoxia-inducible factor 1, alpha subunit inhibitor (HIF1AN), a member of the Fe2+ and 2-oxoglutarate-dependent dioxygenase superfamily, is protein that hydoxylates a specific asparagine residue (Asn-803) within the HIF1alpha C-terminal transactivation domain. In normoxia, the HIF1AN-mediated hydroxylation of the HIF1alpha transactivation domain results in blockage of the HIF1alpha-p300/CBP interaction and represses transcriptional activity of HIF1alpha-targeted genes. Recombinant human HIF1AN protein was expressed in E Coli and purified by using conventional chromatography techniques.
 Product Categories/Family for HIF1AN recombinant protein    Cell Cycle
 Applications Tested/Suitable for HIF1AN recombinant protein   

SDS-PAGE

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 SDS-Page of HIF1AN recombinant protein    HIF1AN recombinant protein SDS-Page image
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NCBI/Uniprot data below describe general gene information for HIF1AN. It may not necessarily be applicable to this product.
 NCBI GI #    148596936
 NCBI GeneID    55662
 NCBI Accession #    NP_060372 [Other Products]
 NCBI GenBank Nucleotide #    NP_060372.2 [Other Products]
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 UniProt Primary Accession #    Q9NWT6 [Other Products]
 UniProt Secondary Accession #    Q5W147; Q969Q7; Q9NPV5; D3DR69 [Other Products]
 UniProt Related Accession #    Q9NWT6 [Other Products]
 Molecular Weight    40.2 kDa (349 aa), confirmed by MALDI-TOF.
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 NCBI Official Full Name    hypoxia-inducible factor 1-alpha inhibitor
 NCBI Official Synonym Full Names    hypoxia inducible factor 1 alpha subunit inhibitor
 NCBI Official Symbol    HIF1AN [Similar Products]
 NCBI Official Synonym Symbols   
FIH1
[Similar Products]
 NCBI Protein Information    hypoxia-inducible factor 1-alpha inhibitor
 UniProt Protein Name    Hypoxia-inducible factor 1-alpha inhibitor
 UniProt Synonym Protein Names   
Factor inhibiting HIF-1; FIH-1; Hypoxia-inducible factor asparagine hydroxylase
 Protein Family    Hypoxia-inducible factor 1-alpha inhibitor
 UniProt Gene Name    HIF1AN [Similar Products]
 UniProt Synonym Gene Names    FIH1; FIH-1 [Similar Products]
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 UniProt Comments for HIF1AN    Hydroxylates HIF-1 alpha at 'Asn-803' in the C-terminal transactivation domain (CAD). Functions as an oxygen sensor and, under normoxic conditions, the hydroxylation prevents interaction of HIF-1 with transcriptional coactivators including Cbp/p300-interacting transactivator. Involved in transcriptional repression through interaction with HIF1A, VHL and histone deacetylases. Hydroxylates specific Asn residues within ankyrin repeat domains (ARD) of NFKB1, NFKBIA, NOTCH1, ASB4, PPP1R12A and several other ARD-containing proteins. Also hydroxylates Asp and His residues within ARDs of ANK1 and TNKS2, respectively. Negatively regulates NOTCH1 activity, accelerating myogenic differentiation. Positively regulates ASB4 activity, promoting vascular differentiation.
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Product References and Citations for HIF1AN recombinant protein

   Fukuba H., et al. (2008) Neurosci Lett. 433 (3):209-14.; Li J., et al. (2007) Mol Cell Biol. 27 (20):7345-53.;
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 Research Articles on HIF1AN    1. MiR-31-5p plays an important role in HS formation by inhibiting FIH and regulating the HIF-1alpha pathway.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with HIF1AN recombinant proteinPathways associated with HIF1AN recombinant protein
 Reference Product  PubMed Publications
 HIF1A recombinant protein  >72 publications with HIF1AN and HIF1A
 EGLN1 recombinant protein  >19 publications with HIF1AN and EGLN1
 VHL recombinant protein  >13 publications with HIF1AN and VHL
 VEGFA recombinant protein  >8 publications with HIF1AN and VEGFA
 NOTCH1 recombinant protein  >5 publications with HIF1AN and NOTCH1
 Products by Pathway  Pathway Diagram
 Cellular Response To Hypoxia Pathway antibodies  Cellular Response To Hypoxia Pathway Diagram
 Cellular Responses To Stress Pathway antibodies  Cellular Responses To Stress Pathway Diagram
 HIF-2-alpha Transcription Factor Network Pathway antibodies  HIF-2-alpha Transcription Factor Network Pathway Diagram
 Hypoxic And Oxygen Homeostasis Regulation Of HIF-1-alpha Pathway antibodies  Hypoxic And Oxygen Homeostasis Regulation Of HIF-1-alpha Pathway Diagram
 Oxygen-dependent Asparagine Hydroxylation Of Hypoxia-inducible Factor Alpha Pathway antibodies  Oxygen-dependent Asparagine Hydroxylation Of Hypoxia-inducible Factor Alpha Pathway Diagram
 Photodynamic Therapy-induced HIF-1 Survival Signaling Pathway antibodies  Photodynamic Therapy-induced HIF-1 Survival Signaling Pathway Diagram
 Regulation Of Hypoxia-inducible Factor (HIF) By Oxygen Pathway antibodies  Regulation Of Hypoxia-inducible Factor (HIF) By Oxygen Pathway Diagram
 MiR-148a/miR-31/FIH1/HIF1α-Notch Signaling In Glioblastoma Pathway antibodies  MiR-148a/miR-31/FIH1/HIF1α-Notch Signaling In Glioblastoma Pathway Diagram
Diseases associated with HIF1AN recombinant proteinOrgans/Tissues associated with HIF1AN recombinant protein
 Disease Name  Pubmed Publications
 Kidney Diseases Antibodies  >13 publications with HIF1AN and Kidney Diseases
 Liver Diseases Antibodies  >7 publications with HIF1AN and Liver Diseases
 Breast Neoplasms Antibodies  >7 publications with HIF1AN and Breast Neoplasms
 Nervous System Diseases Antibodies  >6 publications with HIF1AN and Nervous System Diseases
 Carcinoma, Hepatocellular Antibodies  >5 publications with HIF1AN and Carcinoma, Hepatocellular
 Inflammation Antibodies  >5 publications with HIF1AN and Inflammation
 Brain Diseases Antibodies  >4 publications with HIF1AN and Brain Diseases
 Heart Diseases Antibodies  >4 publications with HIF1AN and Heart Diseases
 Disease Models, Animal Antibodies  >4 publications with HIF1AN and Disease Models, Animal
 Fibrosis Antibodies  >4 publications with HIF1AN and Fibrosis
 Organ/Tissue Name  Pubmed Publications
 Vascular Antibodies  >30 publications with HIF1AN and Vascular
 Blood Antibodies  >20 publications with HIF1AN and Blood
 Kidney Antibodies  >18 publications with HIF1AN and Kidney
 Liver Antibodies  >10 publications with HIF1AN and Liver
 Lung Antibodies  >7 publications with HIF1AN and Lung
 Heart Antibodies  >7 publications with HIF1AN and Heart
 Lymph Node Antibodies  >5 publications with HIF1AN and Lymph Node
 Muscle Antibodies  >5 publications with HIF1AN and Muscle
 Lymph Antibodies  >5 publications with HIF1AN and Lymph
 Prostate Antibodies  >5 publications with HIF1AN and Prostate
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