View our list of available Coronavirus (COVID-19, SARS-CoV-2, 2019-nCOV) antibodies, recombinant proteins, ELISA Kits... Options Full Datasheet Printer Friendly Datasheet Prepare for Printing Full Datasheet Printer Friendly Datasheet Prepare for Printing Have Questions? Ask Us! Request A Quote Today! Add To Compare List HIV-1 Envelope Recombinant Protein Catalog # MBS142590 Unit / Price 0.1 mg / $335 +1 FREE 8GB USB 0.5 mg / $830 +1 FREE 8GB USB 1 mg / $1,265 +1 FREE 8GB USB 5x1 mg / $5,355 +6 FREE 8GB USB Product Name Product Info Accession #s Product Desc Diseases/Tissues/Pathways Applications References Product Name HIV-1 Envelope, Recombinant Protein Popular Item Full Product Name Recombinant HIV-1 Envelope (233) Product Synonym Names HIV-1 Envelope; HIV-1 Envelope Recombinant; HIV-1 Envelope Research Use Only For Research Use Only. Not for use in diagnostic procedures. TOP Host Escherichia Coli Specificity Immunoreactive with all sera of HIV-1 and HIV-type O infected individuals and with 60-80% of HIV-2 infected individuals. Purity/Purification Greater than 95.0% as determined by HPLC analysis and SDS-PAGE. Form/Format The HIV-1 is dissolved in 0.5X PBS and contains 6M urea. Physical Appearance Sterile filtered colorless clear solution (1 mg/ml) Stability HIV-1 envelope 233 a.a although stable at 4°C for 1 week, should be stored below -18°C. Please prevent freeze/thaw cycles. Other Notes Small volumes of HIV-1 Envelope recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply. TOP Related Product Information for HIV-1 Envelope recombinant protein Description: HIV-1 envelope is an E Coli-derived recombinant protein that composes all of the reported immunogenic determinants found in gp41 and a small portion of gp120. The gene encoding this fusion protein was synthesized using codons optimized for E Coli expression and doesn't represent a linear HIV-1 envelope sequence. HIV-1 is a non-glycosylated, 233 amino acid polypeptide chain, having a molecular mass of 27275.88 dalton and pI=9.68. HIV-1 envelope protein spans the C-Terminus of gp120 and most of gp41. Superior reagent for HIV-1 and HIV type-O detection. Detects all HIV-1 and HIV-type O infected individuals responding to envelope proteins.Introduction: Human immunodeficiency virus (HIV) is a retrovirusthat can lead to a condition in which the immune systembegins to fail, leading to opportunistic infections. HIV primarily infects vital cells in the humanimmune systemsuch as helper T cells(specifically CD4+ T cells), macrophagesand dendritic cells. HIV infection leads to low levels of CD4+ T cells through three main mechanisms: firstly, direct viral killing of infected cells; secondly, increased rates of apoptosisin infected cells; and thirdly, killing of infected CD4+ T cells by CD8 cytotoxic lymphocytesthat recognize infected cells. When CD4+ T cell numbers decline below a critical level, cell-mediated immunityis lost, and the body becomes progressively more susceptible to opportunistic infections. HIV was classified as a member of the genus Lentivirus, part of the family of Retroviridae. Lentiviruses have many common morphologies and biological properties. Many species are infected by lentiviruses, which are characteristically responsible for long-duration illnesses with a long incubation period. Lentiviruses are transmitted as single-stranded, positive-sense, enveloped RNA viruses. Upon entry of the target cell, the viral RNA genomeis converted to double-stranded DNAby a virally encoded reverse transcriptasethat is present in the virus particle. This viral DNA is then integrated into the cellular DNA by a virally encoded integraseso that the genome can be transcribed. Once the virus has infected the cell, two pathways are possible: either the virus becomes latentand the infected cell continues to function, or the virus becomes active and replicates, and a large number of virus particles are liberated that can then infect other cells. Product Categories/Family for HIV-1 Envelope recombinant protein Viral Antigens; HUMAN IMMUNODEFICIENCY VIRUS; Viral Antigens; HIV Applications Tested/Suitable for HIV-1 Envelope recombinant protein ELISA (EIA), Western Blot (WB) Application Notes for HIV-1 Envelope recombinant protein Antigen is suitable for ELISA and Western blots, excellent antigen for early detection of HIV seroconvertors with minimal specificity problems. 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