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HLA-G recombinant protein :: HLA class I histocompatibility antigen, alpha chain G Recombinant Protein

Scan QR to view Datasheet Catalog #    MBS717410
SDS-Page
Unit / Price
0.01 mg (E-Coli)  /  $150 +1 FREE 8GB USB
0.05 mg (E-Coli)  /  $190 +1 FREE 8GB USB
0.01 mg (Mammalian-Cell)  /  $225 +1 FREE 8GB USB
0.1 mg (E-Coli)  /  $285 +1 FREE 8GB USB
0.02 mg (Mammalian-Cell)  /  $335 +1 FREE 8GB USB
0.2 mg (E-Coli)  /  $460 +1 FREE 8GB USB
0.05 mg (Mammalian-Cell)  /  $635 +1 FREE 8GB USB
0.5 mg (E-Coli)  /  $750 +1 FREE 8GB USB
0.05 mg (Yeast)  /  $845 +1 FREE 8GB USB
0.1 mg (Mammalian-Cell)  /  $880 +1 FREE 8GB USB
0.05 mg (Baculovirus)  /  $990 +1 FREE 8GB USB
0.2 mg (Yeast)  /  $1,140 +1 FREE 8GB USB
1 mg (E-Coli)  /  $1,180 +1 FREE 8GB USB
0.1 mg (Baculovirus)  /  $1,245 +1 FREE 8GB USB
0.5 mg (Yeast)  /  $1,285 +1 FREE 8GB USB
0.5 mg (Baculovirus)  /  $1,795 +2 FREE 8GB USB
1 mg (Yeast)  /  $1,955 +2 FREE 8GB USB
1 mg (Baculovirus)  /  $2,385 +2 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

HLA class I histocompatibility antigen, alpha chain G (HLA-G), Recombinant Protein

★Popular Item★
 Also Known As   

Recombinant Human HLA class I histocompatibility antigen, alpha chain G protein

 Product Synonym Names    HLA G antigen; MHC class I antigen G
 Product Gene Name   

HLA-G recombinant protein

[Similar Products]
 Product Synonym Gene Name    HLA-6.0; HLAG [Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 MBS717410 COA    COA PDF
 MBS717410 Technical Datasheet    Technical Datasheet PDF
 Sequence Positions    25-338. Full length of the mature protein.
 Sequence    GSHSMRYFSA AVSRPGRGEP RFIAMGYVDD TQFVRFDSDS ACPRMEPRAP WVEQEGPEYW EEETRNTKAH AQTDRMNLQT LRGYYNQSEA SSHTLQWMIG CDLGSDGRLL RGYEQYAYDG KDYLALNEDL RSWTAADTAA QISKRKCEAA NVAEQRRAYL EGTCVEWLHR YLENGKEMLQ RADPPKTHVT HHPVFDYEAT LRCWALGFYP AEIILTWQRD GEDQTQDVEL VETRPAGDGT FQKWAAVVVP SGEEQRYTCH VQHEGLPEPL MLRWKQSSLP TIPIMGIVAG LVVLAAVVTG AAVAAVLWRK KSSD
 OMIM    142871
 3D Structure    ModBase 3D Structure for P17693
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 Host    E Coli or Yeast or Baculovirus or Mammalian Cell
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 Purity/Purification    Greater than 90% as determined by SDS-PAGE. (lot specific)
 Form/Format    Liquid containing glycerol
 Tag Information    This protein contains an N-terminal tag and may also contain a C-terminal Myc-tag. N-terminal host tags may vary (His, His-SUMO, His-B2M, GST). Tag types are determined by various factors including tag-protein stability and, therefore, are subject to change; please inquire for tag information.
 Sterility    Sterile filter available upon request.
 Endotoxin    Low endotoxin available upon request.
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 Production Note    Special Offer: The E. coli host-expressed protein is manufactured from a stock plasmid containing the protein gene. E. coli host-expressed protein is stocked in different unit sizes ranging from as small as 10 ug to as large as 1 mg. Bulk inventory is also available. The E. coli host-expressed protein has been ordered over and over again by researchers and has stood the test of time as both a robust protein and important target for the research community. It is part of our new program to make our most popular protein targets and corresponding hosts available in expanded unit sizes and with a quick processing time. Select E. coli host-expressed protein for the fastest delivery among all hosts. Please contact us or email to support@mybiosource.com for more details.
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 Preparation and Storage    Store at -20 degree C, for extended storage, conserve at -20 degree C or -80 degree C.
 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Other Notes    Small volumes of HLA-G recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for HLA-G recombinant protein

   Involved in the presentation of foreign antigens to the immune system. Plays a role in maternal tolerance of the fetus by mediating protection from the deleterious effects of natural killer cells, cytotoxic T-lymphocytes, macrophages and mononuclear cells.
 Product Categories/Family for HLA-G recombinant protein    Immunology
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 SDS-Page of HLA-G recombinant protein    HLA-G recombinant protein SDS-Page image
(Note: Representative image, actual molecular weight may vary depending on Tag type and expression host)
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NCBI/Uniprot data below describe general gene information for HLA-G. It may not necessarily be applicable to this product.
 NCBI GI #    4504415
 NCBI GeneID    3135
 NCBI Accession #    NP_002118.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_002127.5 [Other Products]
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 UniProt Primary Accession #    P17693 [Other Products]
 Molecular Weight    62.9kD
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 NCBI Official Full Name    HLA class I histocompatibility antigen, alpha chain G
 UniProt Protein Name    HLA class I histocompatibility antigen, alpha chain G
 UniProt Synonym Protein Names   
HLA G antigen; MHC class I antigen G
 Protein Family    HLA class I histocompatibility antigen
 UniProt Gene Name    HLA-G [Similar Products]
 UniProt Synonym Gene Names    HLA-6.0; HLAG [Similar Products]
 UniProt Entry Name    HLAG_HUMAN
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 NCBI Summary for HLA-G    HLA-G belongs to the HLA class I heavy chain paralogues. This class I molecule is a heterodimer consisting of a heavy chain and a light chain (beta-2 microglobulin). The heavy chain is anchored in the membrane. HLA-G is expressed on fetal derived placental cells. The heavy chain is approximately 45 kDa and its gene contains 8 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the alpha1 and alpha2 domain, which both bind the peptide, exon 4 encodes the alpha3 domain, exon 5 encodes the transmembrane region, and exon 6 encodes the cytoplasmic tail. [provided by RefSeq, Jul 2008]
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 UniProt Comments for HLA-G    HLA-G: Involved in the presentation of foreign antigens to the immune system. Plays a role in maternal tolerance of the fetus by mediating protection from the deleterious effects of natural killer cells, cytotoxic T-lymphocytes, macrophages and mononuclear cells. Belongs to the MHC class I family.

Protein type: Membrane protein, integral

Chromosomal Location of Human Ortholog: 6p21.3

Cellular Component: early endosome membrane; Golgi membrane; membrane; MHC class I protein complex; phagocytic vesicle membrane; plasma membrane

Molecular Function: antigen binding; peptide antigen binding; protein homodimerization activity; receptor binding

Biological Process: antigen processing and presentation; antigen processing and presentation of exogenous peptide antigen via MHC class I; antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent; antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent; antigen processing and presentation of peptide antigen via MHC class I; cellular defense response; cytokine and chemokine mediated signaling pathway; immune response-inhibiting cell surface receptor signaling pathway; negative regulation of immune response; negative regulation of T cell proliferation; positive regulation of interleukin-12 production; positive regulation of regulatory T cell differentiation; positive regulation of T cell tolerance induction; positive regulation of tolerance induction; regulation of immune response

Disease: Asthma, Susceptibility To
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Product References and Citations for HLA-G recombinant protein

   The mRNA of a human class I gene HLA G/HLA 6.0 exhibits a restricted pattern of expression.Shukla H., Swaroop A., Srivastava R., Weissman S.M.Nucleic Acids Res. 18:2189-2189(1990) A human major histocompatibility complex class I gene that encodes a protein with a shortened cytoplasmic segment.Geraghty D.E., Koller B.H., Orr H.T.Proc. Natl. Acad. Sci. U.S.A. 84:9145-9149(1987) Ishitani A., Geraghty D.E. A 356-Kb sequence of the subtelomeric part of the MHC class I region.Hampe A., Coriton O., Andrieux N., Carn G., Lepourcelet M., Mottier S., Dreano S., Gatius M.T., Hitte C., Soriano N., Galibert F.DNA Seq. 10:263-299(1999) Homo sapiens 2,229,817bp genomic DNA of 6p21.3 HLA class I region.Shiina S., Tamiya G., Oka A., Inoko H.Disulfide bond-mediated dimerization of HLA-G on the cell surface.Boyson J.E., Erskine R., Whitman M.C., Chiu M., Lau J.M., Koopman L.A., Valter M.M., Angelisova P., Horejsi V., Strominger J.L.Proc. Natl. Acad. Sci. U.S.A. 99:16180-16185(2002) Crystal structure of HLA-G a nonclassical MHC class I molecule expressed at the fetal-maternal interface.Clements C.S., Kjer-Nielsen L., Kostenko L., Hoare H.L., Dunstone M.A., Moses E., Freed K., Brooks A.G., Rossjohn J., McCluskey J.Proc. Natl. Acad. Sci. U.S.A. 102:3360-3365(2005) Efficient leukocyte Ig-like receptor signaling and crystal structure of disulfide-linked HLA-G dimer.Shiroishi M., Kuroki K., Ose T., Rasubala L., Shiratori I., Arase H., Tsumoto K., Kumagai I., Kohda D., Maenaka K.J. Biol. Chem. 281:10439-10447(2006)
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 Research Articles on HLA-G    1. HLA-G 3'UTR polymorphisms associated with a greater magnitude of HLA-G production were associated with differentiated thyroid tumours and with variables implicated in poor prognosis.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with HLA-G recombinant proteinPathways associated with HLA-G recombinant protein
 Reference Product  PubMed Publications
 IL10 recombinant protein  >93 publications with HLA-G and IL10
 KLRD1 recombinant protein  >27 publications with HLA-G and KLRD1
 B2M recombinant protein  >5 publications with HLA-G and B2M
 ADM2 recombinant protein  >2 publications with HLA-G and ADM2
 MMP15 recombinant protein  >1 publications with HLA-G and MMP15
 Products by Pathway  Pathway Diagram
 Adaptive Immune System Pathway antibodies  Adaptive Immune System Pathway Diagram
 Allograft Rejection Pathway antibodies  Allograft Rejection Pathway Diagram
 Allograft Rejection Pathway antibodies  Allograft Rejection Pathway Diagram
 Allograft Rejection Pathway antibodies  Allograft Rejection Pathway Diagram
 Antigen Presentation: Folding, Assembly And Peptide Loading Of Class I MHC Pathway antibodies  Antigen Presentation: Folding, Assembly And Peptide Loading Of Class I MHC Pathway Diagram
 Antigen Processing And Presentation Pathway antibodies  Antigen Processing And Presentation Pathway Diagram
 Antigen Processing And Presentation Pathway antibodies  Antigen Processing And Presentation Pathway Diagram
 Antigen Processing-Cross Presentation Pathway antibodies  Antigen Processing-Cross Presentation Pathway Diagram
 Autoimmune Thyroid Disease Pathway antibodies  Autoimmune Thyroid Disease Pathway Diagram
 Autoimmune Thyroid Disease Pathway antibodies  Autoimmune Thyroid Disease Pathway Diagram
Diseases associated with HLA-G recombinant proteinOrgans/Tissues associated with HLA-G recombinant protein
 Disease Name  Pubmed Publications
 Inflammation Antibodies  >89 publications with HLA-G and Inflammation
 Skin Diseases Antibodies  >85 publications with HLA-G and Skin Diseases
 Necrosis Antibodies  >54 publications with HLA-G and Necrosis
 Nervous System Diseases Antibodies  >41 publications with HLA-G and Nervous System Diseases
 Breast Neoplasms Antibodies  >38 publications with HLA-G and Breast Neoplasms
 Asthma Antibodies  >35 publications with HLA-G and Asthma
 Ovarian Neoplasms Antibodies  >23 publications with HLA-G and Ovarian Neoplasms
 Kidney Diseases Antibodies  >18 publications with HLA-G and Kidney Diseases
 Brain Diseases Antibodies  >16 publications with HLA-G and Brain Diseases
 Bone Marrow Diseases Antibodies  >16 publications with HLA-G and Bone Marrow Diseases
 Organ/Tissue Name  Pubmed Publications
 Placenta Antibodies  >495 publications with HLA-G and Placenta
 Lung Antibodies  >43 publications with HLA-G and Lung
 Brain Antibodies  >33 publications with HLA-G and Brain
 Thymus Antibodies  >25 publications with HLA-G and Thymus
 Stomach Antibodies  >11 publications with HLA-G and Stomach
 Intestine Antibodies  >8 publications with HLA-G and Intestine
 Testis Antibodies  >5 publications with HLA-G and Testis
 Pancreas Antibodies  >4 publications with HLA-G and Pancreas
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