Antibody Protein ELISA Kit from MyBioSource header Telephone 1.858.633.0165          
1.855.MyBioSource
Fax 1.858.633.0166    Email sales@mybiosource.com 
tel/fax
menu1 Home Products Ordering Company Help menu7
bottom
   MyBioSource rightarrow Recombinant Protein rightarrow HMGCR  rightarrow LOG IN  rightarrow MY ACCOUNT  rightarrow CART CONTENTS  rightarrow CHECKOUT 
horiz bar
MyBioSource Menu separator
separator
ELISA Kit ELISA Kit
CLIA Kit CLIA Kit
PCR Kit PCR Kit
Monoclonal Antibody Monoclonal Antibody
Polyclonal Antibody Polyclonal Antibody
Secondary Antibody Secondary Antibody
Antigen Antigen
Biochemical Biochemical
cDNA Clone cDNA Clone
siRNA siRNA
Peptide Peptide
Recombinant/Purified Protein Rec./Purified Protein

Custom ELISA Kit Custom ELISA Kit
Custom Protein Custom Protein
Custom Antibody Custom Antibody
Antibody Matched Pairs Antibody Matched Pairs
Antibody & Corresponding Blocking Peptide Pairs Antibody Peptide Pairs
Phospho-Specific Antibodies Phospho Antibodies
Products by Disease Products by Disease
Products by Pathway Products by Pathway
Products by Tissue Products by Tissue

arrow Advanced Search
arrow Submit Technical Q&A
arrow International Distributors
arrow Contact Us
separator
Our Best Sellers moreseparator
separator
 • Fade Mounting Medium Reagent
 • TCR gamma delta Antibody
 • ADAM metallopeptidase domain 17 (ADAM17) Antibody
 • choroideremia (Rab escort protein 1) (CHM) ELISA Kit
 • b-Catenin (pY280) (b-Catenin (pY280)) Antibody
 • Sialidase 1 (NEU1) Recombinant Protein
 • NDRG2 Antibody
 • HLA class II histocompatibility antigen, DRB1-1 beta chain (... Recombinant Protein
 • Mucin 5AC (MUC5AC) Antibody
 • UBC13 Antibody
 • MED18 Antibody
 • Granulocyte Macrophage Colony Stimulating Factor (CSF2) Protein
 • PEBP (phosphatidylethanolamie binding protein) (PEBP1) Antibody
 • BCL-2 Antibody
 downarrow more ...
separator
separator
DatasheetFull DatasheetPrinter Friendly DatasheetPrint This DatasheetAdd to Compare ListHave Questions? Ask UsRequest for a Quotation today

HMGCR recombinant protein :: HMG-CoA Reductase Catalytic Domain Recombinant Protein

Scan QR to view Datasheet Catalog #    MBS845121
Testing Data
Unit / Price
0.1 mg  /  $145 +1 FREE 8GB USB
0.5 mg  /  $375 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

HMG-CoA Reductase Catalytic Domain (HMGCR), Recombinant Protein

★Popular Item★
 Also Known As   

HMG-CoA Reductase Catalytic Domain (GST Tagged), human recombinant

 Product Synonym Names    3-Hydroxy-3-methylglutaryl-CoA reductase; HMGR; HMGCR
 Product Gene Name   

HMGCR recombinant protein

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
Table BarTOPTable Bar
 OMIM    142910
 3D Structure    ModBase 3D Structure for P04035
Section Bar
 Host    E Coli
Section Bar
 Purity/Purification    >=90%
 Form/Format    Lyophilized from proprietary buffer containing BSA
Appearance: Lyophilized
Section Bar
 Solubility/Reconstitution Instructions    Briefly spin down the vial and reconstitute in 50% glycerol in PBS to 0.5-1.0 mg/ml and store at -80 degree C.
 Activity (Specifications/test method)    The specific activity was determined to be > 1.0 Unit/mg by MyBioSource's HMG-CoA reductase Activity/Inhibitor Screening Kit.
 Results    > 1.0 Unit/mg
 Unit Definition    One unit is defined as the amount of enzyme required to convert 1.0 mumole of NADPH to NADP+ per minute at 37 degree C
 Handling    Centrifuge the vial prior to opening.
Section Bar
 Preparation and Storage    At -80 degree C
Shelf Life: 12 months
 Other Notes    Small volumes of HMGCR recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Table BarTOPTable Bar
 

Related Product Information for HMGCR recombinant protein

   Background: HMG-CoA reductase (3-hydroxy-3-methyl-glutaryl-CoA reductase or HMGR) (EC 1.1.1.34) is a transmembrane protein involved in the mevalonate pathway, the metabolic pathway that produces cholesterol from acetyl-CoA. In an NADPH-dependent reaction, HMG-CoA reductase reduces HMG-CoA to generate mevalonate and CoA. Since HMG-CoA reductase catalyzes the rate limiting step in cholesterol synthesis, it is a primary target of a group of cholesterol-lowering drugs known as statins. Inhibition of HMG-CoA reductase induces expression of LDL receptors in the liver, which lowers plasma concentration of cholesterol.
 Product Categories/Family for HMGCR recombinant protein    Proteins and Enzymes; Animal-Free Origin (AOF) Recombinant Proteins & EnzymesProteins and Enzymes; Proteins and Enzymes (A-Z)
 Applications Tested/Suitable for HMGCR recombinant protein   

SDS-PAGE

Section Bar
 Testing Data of HMGCR recombinant protein    HMGCR recombinant protein Testing Data image
Table BarTOPTable Bar
NCBI/Uniprot data below describe general gene information for HMGCR. It may not necessarily be applicable to this product.
 NCBI GI #    4557643
 NCBI GeneID    3156
 NCBI Accession #    NP_000850.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_000859.2 [Other Products]
Section Bar
 UniProt Primary Accession #    P04035 [Other Products]
 UniProt Secondary Accession #    Q8N190; B7Z3Y9 [Other Products]
 UniProt Related Accession #    P04035 [Other Products]
 Molecular Weight    75.9 kDa (426-888 aa, NT GST Tag)
Table BarTOPTable Bar
 NCBI Official Full Name    3-hydroxy-3-methylglutaryl-Coenzyme A reductase isoform 1
 NCBI Official Synonym Full Names    3-hydroxy-3-methylglutaryl-CoA reductase
 NCBI Official Symbol    HMGCR [Similar Products]
 NCBI Official Synonym Symbols   
LDLCQ3
[Similar Products]
 NCBI Protein Information    3-hydroxy-3-methylglutaryl-Coenzyme A reductase
 UniProt Protein Name    3-hydroxy-3-methylglutaryl-coenzyme A reductase
 UniProt Gene Name    HMGCR [Similar Products]
 UniProt Synonym Gene Names    HMG-CoA reductase [Similar Products]
 UniProt Entry Name    HMDH_HUMAN
Section Bar
 NCBI Summary for HMGCR    HMG-CoA reductase is the rate-limiting enzyme for cholesterol synthesis and is regulated via a negative feedback mechanism mediated by sterols and non-sterol metabolites derived from mevalonate, the product of the reaction catalyzed by reductase. Normally in mammalian cells this enzyme is suppressed by cholesterol derived from the internalization and degradation of low density lipoprotein (LDL) via the LDL receptor. Competitive inhibitors of the reductase induce the expression of LDL receptors in the liver, which in turn increases the catabolism of plasma LDL and lowers the plasma concentration of cholesterol, an important determinant of atherosclerosis. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2008]
Section Bar
 UniProt Comments for HMGCR    HMGCR: the rate-limiting enzyme for cholesterol synthesis. Regulated via a negative feedback mechanism mediated by sterols and non-sterol metabolites derived from mevalonate, the product of the reaction catalyzed by this reductase. Normally in mammalian cells this enzyme is suppressed by cholesterol derived from the internalization and degradation of low density lipoprotein (LDL) via the LDL receptor. Competitive inhibitors of the reductase induce the expression of LDL receptors in the liver, which in turn increases the catabolism of plasma LDL and lowers the plasma concentration of cholesterol, an important determinant of atherosclerosis.

Protein type: Membrane protein, multi-pass; Endoplasmic reticulum; EC 1.1.1.34; Secondary Metabolites Metabolism - terpenoid backbone biosynthesis; Membrane protein, integral; Motility/polarity/chemotaxis; Oxidoreductase

Chromosomal Location of Human Ortholog: 5q13.3-q14

Cellular Component: peroxisomal membrane; endoplasmic reticulum membrane; endoplasmic reticulum; integral to membrane

Molecular Function: protein binding; protein homodimerization activity; hydroxymethylglutaryl-CoA reductase (NADPH) activity; hydroxymethylglutaryl-CoA reductase activity; coenzyme binding

Biological Process: coenzyme A metabolic process; myoblast differentiation; negative regulation of MAP kinase activity; ubiquinone metabolic process; response to ethanol; isoprenoid biosynthetic process; negative regulation of vasodilation; positive regulation of smooth muscle cell proliferation; visual learning; positive regulation of skeletal muscle development; cellular lipid metabolic process; cholesterol biosynthetic process; protein tetramerization; response to nutrient; positive regulation of stress-activated MAPK cascade; aging
Table BarTOPTable Bar
 Research Articles on HMGCR    1. The effect of lower LDL-C on the risk of coronary heart disease mediated by polymorphisms in NPC1L1, HMGCR, or both is approximately the same per unit lower LDL-C and log-linearly proportional to the absolute exposure to lower LDL-C.
Table BarTOPTable Bar
 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
Table BarTOPTable Bar
Products associated with HMGCR recombinant proteinPathways associated with HMGCR recombinant protein
 Reference Product  PubMed Publications
 SREBF2 recombinant protein  >29 publications with HMGCR and SREBF2
 HMGCS1 recombinant protein  >20 publications with HMGCR and HMGCS1
 INSIG1 recombinant protein  >5 publications with HMGCR and INSIG1
 MVK recombinant protein  >4 publications with HMGCR and MVK
 PPARA recombinant protein  >2 publications with HMGCR and PPARA
 HMGCS2 recombinant protein  >2 publications with HMGCR and HMGCS2
 UBIAD1 recombinant protein  >1 publications with HMGCR and UBIAD1
 UBC recombinant protein  >1 publications with HMGCR and UBC
 Products by Pathway  Pathway Diagram
 AMPK Signaling Pathway antibodies  AMPK Signaling Pathway Diagram
 AMPK Signaling Pathway antibodies  AMPK Signaling Pathway Diagram
 AMPK Signaling Pathway antibodies  AMPK Signaling Pathway Diagram
 Activation Of Gene Expression By SREBF (SREBP) Pathway antibodies  Activation Of Gene Expression By SREBF (SREBP) Pathway Diagram
 Bile Secretion Pathway antibodies  Bile Secretion Pathway Diagram
 Bile Secretion Pathway antibodies  Bile Secretion Pathway Diagram
 Biosynthesis Of Antibiotics Pathway antibodies  Biosynthesis Of Antibiotics Pathway Diagram
 C5 Isoprenoid Biosynthesis, Mevalonate Pathway antibodies  C5 Isoprenoid Biosynthesis, Mevalonate Pathway Diagram
 C5 Isoprenoid Biosynthesis, Mevalonate Pathway antibodies  C5 Isoprenoid Biosynthesis, Mevalonate Pathway Diagram
 Cholesterol Biosynthesis Pathway antibodies  Cholesterol Biosynthesis Pathway Diagram
Diseases associated with HMGCR recombinant proteinOrgans/Tissues associated with HMGCR recombinant protein
 Disease Name  Pubmed Publications
 Cardiovascular Diseases Antibodies  >67 publications with HMGCR and Cardiovascular Diseases
 Fatty Liver Antibodies  >53 publications with HMGCR and Fatty Liver
 Nervous System Diseases Antibodies  >47 publications with HMGCR and Nervous System Diseases
 Atherosclerosis Antibodies  >47 publications with HMGCR and Atherosclerosis
 Hypercholesterolemia Antibodies  >46 publications with HMGCR and Hypercholesterolemia
 Dyslipidemias Antibodies  >44 publications with HMGCR and Dyslipidemias
 Liver Diseases Antibodies  >39 publications with HMGCR and Liver Diseases
 Hyperlipidemias Antibodies  >36 publications with HMGCR and Hyperlipidemias
 Inflammation Antibodies  >32 publications with HMGCR and Inflammation
 Necrosis Antibodies  >30 publications with HMGCR and Necrosis
 Organ/Tissue Name  Pubmed Publications
 Liver Antibodies  >175 publications with HMGCR and Liver
 Blood Antibodies  >169 publications with HMGCR and Blood
 Muscle Antibodies  >42 publications with HMGCR and Muscle
 Brain Antibodies  >36 publications with HMGCR and Brain
 Heart Antibodies  >35 publications with HMGCR and Heart
 Kidney Antibodies  >25 publications with HMGCR and Kidney
 Vascular Antibodies  >24 publications with HMGCR and Vascular
 Ovary Antibodies  >16 publications with HMGCR and Ovary
 Connective Tissue Antibodies  >12 publications with HMGCR and Connective Tissue
 Intestine Antibodies  >11 publications with HMGCR and Intestine
Table BarTOPTable Bar
horiz bar
 SSL   Follow us on Facebook Follow us onTwitter Follow us on Google Plus Connect us on LinkedIn Subscribe to our RSS Feed for latest products and special promotions