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HMGA1 recombinant protein

Scan QR to view Datasheet Catalog #    MBS204657
SDS-PAGE
Unit / Price
0.05 mg  /  $375 +1 FREE 8GB USB
0.25 mg  /  $925 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

HMGA1, Recombinant Protein

 Also Known As   

HMGA1, 1-107aa, Human, His tag, E Coli

 Product Synonym Names    High mobility group protein HMG-I/HMG-Y; HMG-R; HMGA1A; HMGIY
 Product Gene Name   

HMGA1 recombinant protein

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Sequence    MSESSSKSSQ PLASKQEKDG TEKRGRGRPR KQPPVSPGTA LVGSQKEPSE VPTPKRPRGR PKGSKNKGAA KTRKTTTTPG RKPRGRPKKL EKEEEEGISQ ESSEEEQLEH HHHHH
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 Purity/Purification    > 90% by SDS - PAGE
 Form/Format    Liquid. In 20mM Tris-HCl buffer (pH 8.0) containing 50% glycerol, 0.2M NaCl
 Concentration    0.25 mg/ml (determined by BCA assay) (lot specific)
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 Antigen Species    Human
 Tag    His-tag
 Expression System    E Coli
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 Preparation and Storage    Can be stored at 4 degree C short term (1-2 weeks). For long term storage, aliquot and store at -20 degree C or -70 degree C. Avoid repeated freezing and thawing cycles.
 Other Notes    Small volumes of HMGA1 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Product Description specifically for HMGA1 recombinant protein

   High mobility group protein HMG-I/HMG-Y, also known as HMGA1, is a member of the non-histone chromosomal high mobility group protein (HMG) family. HMGA1 consists of a highly conserved AT-hook DNA-binding domain that mediates binding to AT-rich sequences in the minor groove of chromosomal DNA. It functions as architectural chromatin-binding transcription factor altering the conformation of DNA by modulating nuclear protein-DNA complexes. It is involved in many cellular processes including growth regulation, viral induction of beta-IFN gene and regulation of inducible gene transcription. Recombinant human HMGA1 protein, fused to His-tag at C-terminus, was expressed in E.coli and purified by using conventional chromatography techniques.
 Product Categories/Family for HMGA1 recombinant protein    Signal Transduction
 Applications Tested/Suitable for HMGA1 recombinant protein   

SDS-PAGE

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 SDS-PAGE of HMGA1 recombinant protein    HMGA1 recombinant protein SDS-PAGE image
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NCBI/Uniprot data below describe general gene information for HMGA1. It may not necessarily be applicable to this product.
 NCBI GI #    22208967
 NCBI GeneID    3159
 NCBI Accession #    NP_665906 [Other Products]
 NCBI GenBank Nucleotide #    NM_145899.2 [Other Products]
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 UniProt Secondary Accession #    P10910; Q5T6U9; Q9UKB0 [Other Products]
 UniProt Related Accession #    P17096 [Other Products]
 Molecular Weight    12.7 kDa (115aa), confirmed by MALDI-TOF (Molecular weight on SDS-PAGE will appear higher)
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 NCBI Official Full Name    high mobility group protein HMG-I/HMG-Y isoform a
 NCBI Official Synonym Full Names    high mobility group AT-hook 1
 NCBI Official Symbol    HMGA1 [Similar Products]
 NCBI Official Synonym Symbols   
HMG-R; HMGIY; HMGA1A
[Similar Products]
 NCBI Protein Information    high mobility group protein HMG-I/HMG-Y; HMG-I(Y); high mobility group protein A1; high mobility group protein R; high-mobility group (nonhistone chromosomal) protein isoforms I and Y; nonhistone chromosomal high-mobility group protein HMG-I/HMG-Y
 UniProt Protein Name    High mobility group protein HMG-I/HMG-Y
 UniProt Synonym Protein Names   
High mobility group AT-hook protein 1; High mobility group protein A1; High mobility group protein R
 Protein Family    High mobility group protein
 UniProt Gene Name    HMGA1 [Similar Products]
 UniProt Synonym Gene Names    HMGIY; HMG-I(Y); High mobility group protein A1 [Similar Products]
 UniProt Entry Name    HMGA1_HUMAN
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 NCBI Summary for HMGA1    This gene encodes a non-histone protein involved in many cellular processes, including regulation of inducible gene transcription, integration of retroviruses into chromosomes, and the metastatic progression of cancer cells. The encoded protein preferentially binds to the minor groove of A+T-rich regions in double-stranded DNA. It has little secondary structure in solution but assumes distinct conformations when bound to substrates such as DNA or other proteins. The encoded protein is frequently acetylated and is found in the nucleus. At least seven transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
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 UniProt Comments for HMGA1    HMGA1: HMG-I/Y bind preferentially to the minor groove of A+T rich regions in double stranded DNA. It is suggested that these proteins could function in nucleosome phasing and in the 3'-end processing of mRNA transcripts. They are also involved in the transcription regulation of genes containing, or in close proximity to A+T-rich regions. A chromosomal aberration involving HMGA1 is found in pulmonary chondroid hamartoma. Translocation t(6;14)(p21;q23-24) with RAD51B. Belongs to the HMGA family. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: DNA-binding

Chromosomal Location of Human Ortholog: 6p21

Cellular Component: nucleoplasm; transcription factor complex; focal adhesion; nucleus; cytosol

Molecular Function: retinoid X receptor binding; protein binding; peroxisome proliferator activated receptor binding; enzyme binding; DNA-(apurinic or apyrimidinic site) lyase activity; ligand-dependent nuclear receptor transcription coactivator activity; DNA binding; AT DNA binding; retinoic acid receptor binding; 5'-deoxyribose-5-phosphate lyase activity; transcription factor binding

Biological Process: DNA unwinding during replication; transcription, DNA-dependent; viral reproduction; response to virus; positive regulation of transcription, DNA-dependent; DNA catabolic process, endonucleolytic; negative regulation of cell proliferation; negative regulation of chromatin silencing; regulation of transcription, DNA-dependent; nucleosome disassembly; base-excision repair; protein complex assembly; negative regulation of transcription, DNA-dependent
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Product References and Citations for HMGA1 recombinant protein

   Chiappetta G., et al. (2004) Clin Cancer Res. 10(22):7637-44.
Massaad Massade L., et al. (2002) Biochemistry. 41:2760-2768.
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 Research Articles on HMGA1    1. The prognostic significance of the HMGA-1 antigen was not confirmed in pituitary adenomas with residual tumor growth.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products related to HMGA1, 1-107aa, Human, His tag, E Coli
 Catalog #  Product Name  Catalog #  Product Name
 MBS2012682  FITC-linked Antibody to High Mobility Group AT Hook Protein 1 (HMGA1)  MBS127730  HMGA1
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 MBS2062530  APC/CY7-Linked Polyclonal Antibody to High Mobility Group AT Hook Protein 1 (HMGA1)  MBS959766  Recombinant Human High mobility group protein HMG-I/HMG-Y (HMGA1)
 MBS8222367  HMGA1 siRNA (Rat)  MBS2005789  Polyclonal Antibody to High Mobility Group AT Hook Protein 1 (HMGA1)
 MBS2007390  Biotin-Linked Antibody to High Mobility Group AT Hook Protein 1 (HMGA1)  MBS2062540  HRP-Linked Polyclonal Antibody to High Mobility Group AT Hook Protein 1 (HMGA1)
Products associated with HMGA1 recombinant proteinPathways associated with HMGA1 recombinant protein
 Reference Product  PubMed Publications
 MYC recombinant protein  >18 publications with HMGA1 and MYC
 MAX recombinant protein  >8 publications with HMGA1 and MAX
 HIPK2 recombinant protein  >7 publications with HMGA1 and HIPK2
 PRMT6 recombinant protein  >4 publications with HMGA1 and PRMT6
 PPARG recombinant protein  >3 publications with HMGA1 and PPARG
 CREBBP recombinant protein  >3 publications with HMGA1 and CREBBP
 CDK1 recombinant protein  >2 publications with HMGA1 and CDK1
 HNRNPA1 recombinant protein  >1 publications with HMGA1 and HNRNPA1
 Products by Pathway  Pathway Diagram
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 APOBEC3G Mediated Resistance To HIV-1 Infection Pathway antibodies  APOBEC3G Mediated Resistance To HIV-1 Infection Pathway Diagram
 Adipogenesis Pathway antibodies  Adipogenesis Pathway Diagram
 Autointegration Results In Viral DNA Circles Pathway antibodies  Autointegration Results In Viral DNA Circles Pathway Diagram
 Cellular Senescence Pathway antibodies  Cellular Senescence Pathway Diagram
 Cellular Responses To Stress Pathway antibodies  Cellular Responses To Stress Pathway Diagram
 DNA Damage/Telomere Stress Induced Senescence Pathway antibodies  DNA Damage/Telomere Stress Induced Senescence Pathway Diagram
 Disease Pathway antibodies  Disease Pathway Diagram
 Early Phase Of HIV Life Cycle Pathway antibodies  Early Phase Of HIV Life Cycle Pathway Diagram
 Formation Of Senescence-Associated Heterochromatin Foci (SAHF) Pathway antibodies  Formation Of Senescence-Associated Heterochromatin Foci (SAHF) Pathway Diagram
Diseases associated with HMGA1 recombinant proteinOrgans/Tissues associated with HMGA1 recombinant protein
 Disease Name  Pubmed Publications
 Carcinoma Antibodies  >97 publications with HMGA1 and Carcinoma
 Cell Transformation, Neoplastic Antibodies  >81 publications with HMGA1 and Cell Transformation, Neoplastic
 Chromosome Aberrations Antibodies  >66 publications with HMGA1 and Chromosome Aberrations
 Uterine Neoplasms Antibodies  >39 publications with HMGA1 and Uterine Neoplasms
 Breast Neoplasms Antibodies  >36 publications with HMGA1 and Breast Neoplasms
 Neoplasms, Experimental Antibodies  >32 publications with HMGA1 and Neoplasms, Experimental
 Immune System Diseases Antibodies  >27 publications with HMGA1 and Immune System Diseases
 Neoplasm Metastasis Antibodies  >25 publications with HMGA1 and Neoplasm Metastasis
 Nervous System Diseases Antibodies  >25 publications with HMGA1 and Nervous System Diseases
 Lung Neoplasms Antibodies  >23 publications with HMGA1 and Lung Neoplasms
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >62 publications with HMGA1 and Blood
 Lung Antibodies  >43 publications with HMGA1 and Lung
 Muscle Antibodies  >38 publications with HMGA1 and Muscle
 Embryonic Tissue Antibodies  >36 publications with HMGA1 and Embryonic Tissue
 Liver Antibodies  >30 publications with HMGA1 and Liver
 Vascular Antibodies  >26 publications with HMGA1 and Vascular
 Brain Antibodies  >20 publications with HMGA1 and Brain
 Prostate Antibodies  >18 publications with HMGA1 and Prostate
 Heart Antibodies  >16 publications with HMGA1 and Heart
 Eye Antibodies  >13 publications with HMGA1 and Eye
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