NP_665906
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
12.7 kDa (115aa), confirmed by MALDI-TOF (Molecular weight on SDS-PAGE will appear higher)
NCBI Official Full Name
high mobility group protein HMG-I/HMG-Y isoform a
NCBI Official Synonym Full Names
high mobility group AT-hook 1
NCBI Protein Information
high mobility group protein HMG-I/HMG-Y
UniProt Protein Name
High mobility group protein HMG-I/HMG-Y
UniProt Synonym Protein Names
High mobility group AT-hook protein 1; High mobility group protein A1; High mobility group protein R
UniProt Synonym Gene Names
NCBI Summary for HMGA1
This gene encodes a chromatin-associated protein involved in the regulation of gene transcription, integration of retroviruses into chromosomes, and the metastatic progression of cancer cells. The encoded protein preferentially binds to the minor groove of AT-rich regions in double-stranded DNA. Multiple transcript variants encoding different isoforms have been found for this gene. Pseudogenes of this gene have been identified on multiple chromosomes. [provided by RefSeq, Jan 2016]
UniProt Comments for HMGA1
HMG-I/Y bind preferentially to the minor groove of A+T rich regions in double-stranded DNA. It is suggested that these proteins could function in nucleosome phasing and in the 3'-end processing of mRNA transcripts. They are also involved in the transcription regulation of genes containing, or in close proximity to A+T-rich regions.
Product References and Citations for HMGA1 recombinant protein
Chiappetta G., et al. (2004) Clin Cancer Res. 10 (22):7637-44.; Massaad Massade L., et al. (2002) Biochemistry. 41:2760-2768.
Research Articles on HMGA1
Precautions
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Disclaimer
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Products associated with HMGA1 recombinant protein
Pathways associated with HMGA1 recombinant protein
Diseases associated with HMGA1 recombinant protein
Organs/Tissues associated with HMGA1 recombinant protein
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