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HPRT1 recombinant protein

Scan QR to view Datasheet Catalog #    MBS203544
SDS-Page
Unit / Price
0.1 mg  /  $285 +1 FREE 8GB USB
0.5 mg  /  $640 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

HPRT1, Recombinant Protein

★Popular Item★
 Also Known As   

HPRT1, 1-218aa, Human, His tag, E Coli

 Product Synonym Names    Hypoxanthine-guanine phosphoribosyltransferase; HGPRT; HGPRTase; HPRT; Hypoxanthine-guanine phosphoribosyltransferase HPRT 1; HPRT1; Hypoxanthine guanine phosphoribosyltransferase; Hypoxanthine phosphoribosyltransferase 1 (Lesch Nyhan syndrome); Hypoxanthine phosphoribosyltransferase 1.
 Product Gene Name   

HPRT1 recombinant protein

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Sequence    MGSSHHHHHH SSGLVPRGSH MATRSPGVVI SDDEPGYDLD LFCIPNHYAE DLERVFIPHG LIMDRTERLA RDVMKEMGGH HIVALCVLKG GYKFFADLLD YIKALNRNSD RSIPMTVDFI RLKSYCNDQS TGDIKVIGGD DLSTLTGKNV LIVEDIIDTG KTMQTLLSLV RQYNPKMVKV ASLLVKRTPR SVGYKPDFVG FEIPDKFVVG YALDYNEYFR DLNHVCVISE TGKAKYKA
 OMIM    M31642 mRNA
 3D Structure    ModBase 3D Structure for P00492
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 Host    E Coli
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 Purity/Purification    > 95% by SDS-PAGE
 Form/Format    Liquid. In 20mM Tris-HCl Buffer (pH 8.0) containing, 20% glycerol
 Concentration    0.5 mg/ml (determined by Bradford assay) (lot specific)
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 Antigen Species    Human
 Tag Information    His-tag
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 Preparation and Storage    Can be stored at 4 degree C short term (1-2 weeks).
For long term storage, aliquot and store at -20 degree C or -70 degree C.
Avoid repeated freezing and thawing cycles.
 Other Notes    Small volumes of HPRT1 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for HPRT1 recombinant protein

   Hypoxanthine-guanine phosphoribosyltransferase, also known as HPRT1 has a central role in the generation of purine nucleotides through the purine salvage pathway. The enzyme primarily functions to salvage purines from degraded DNA to renewed purine synthesis. In this role, it acts as a catalyst in the reaction between guanine and phosphoribosyl pyrophosphate to form GMP. Recombinant human HPRT1, fused to His-tag at N-terminus, was expressed in E Coli and purified by using conventional chromatography techniques.
 Product Categories/Family for HPRT1 recombinant protein    Enzymes & Proteases
 Applications Tested/Suitable for HPRT1 recombinant protein   

SDS-PAGE

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 SDS-Page of HPRT1 recombinant protein    HPRT1 recombinant protein SDS-Page image
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NCBI/Uniprot data below describe general gene information for HPRT1. It may not necessarily be applicable to this product.
 NCBI GI #    4504483
 NCBI GeneID    3251
 NCBI Accession #    NP_000185 [Other Products]
 NCBI GenBank Nucleotide #    NM_000194.2 [Other Products]
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 UniProt Primary Accession #    P00492 [Other Products]
 UniProt Secondary Accession #    A6NHF0; B2R8M9 [Other Products]
 UniProt Related Accession #    P00492 [Other Products]
 Molecular Weight    26.7 kDa (238aa), confirmed by MALDI-TOF
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 NCBI Official Full Name    hypoxanthine-guanine phosphoribosyltransferase
 NCBI Official Synonym Full Names    hypoxanthine phosphoribosyltransferase 1
 NCBI Official Symbol    HPRT1 [Similar Products]
 NCBI Official Synonym Symbols   
HPRT; HGPRT
[Similar Products]
 NCBI Protein Information    hypoxanthine-guanine phosphoribosyltransferase
 UniProt Protein Name    Hypoxanthine-guanine phosphoribosyltransferase
 Protein Family    Hypoxanthine-guanine phosphoribosyltransferase
 UniProt Gene Name    HPRT1 [Similar Products]
 UniProt Synonym Gene Names    HPRT; HGPRT; HGPRTase [Similar Products]
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 NCBI Summary for HPRT1    The protein encoded by this gene is a transferase, which catalyzes conversion of hypoxanthine to inosine monophosphate and guanine to guanosine monophosphate via transfer of the 5-phosphoribosyl group from 5-phosphoribosyl 1-pyrophosphate. This enzyme plays a central role in the generation of purine nucleotides through the purine salvage pathway. Mutations in this gene result in Lesch-Nyhan syndrome or gout.[provided by RefSeq, Jun 2009]
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 UniProt Comments for HPRT1    Converts guanine to guanosine monophosphate, and hypoxanthine to inosine monophosphate. Transfers the 5-phosphoribosyl group from 5-phosphoribosylpyrophosphate onto the purine. Plays a central role in the generation of purine nucleotides through the purine salvage pathway.
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Product References and Citations for HPRT1 recombinant protein

   Hladnik u., et al. (2008) Arch Neurol. 65 (9):1240-3.; Sculley DG., et al. (1992) Hum Genet. 90 (3):195-207191.;
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 Research Articles on HPRT1    1. mutation in the human HPRT1 gene and the Lesch-Nyhan disease
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with HPRT1 recombinant proteinPathways associated with HPRT1 recombinant protein
 Reference Product  PubMed Publications
 APRT recombinant protein  >150 publications with HPRT1 and APRT
 PNP recombinant protein  >50 publications with HPRT1 and PNP
 IMPDH2 recombinant protein  >3 publications with HPRT1 and IMPDH2
 GUK1 recombinant protein  >2 publications with HPRT1 and GUK1
 GMPS recombinant protein  >2 publications with HPRT1 and GMPS
 AMPD3 recombinant protein  >1 publications with HPRT1 and AMPD3
 AMPD2 recombinant protein  >1 publications with HPRT1 and AMPD2
 ADSS recombinant protein  >1 publications with HPRT1 and ADSS
 Products by Pathway  Pathway Diagram
 Drug Metabolism - Other Enzymes Pathway antibodies  Drug Metabolism - Other Enzymes Pathway Diagram
 Drug Metabolism - Other Enzymes Pathway antibodies  Drug Metabolism - Other Enzymes Pathway Diagram
 Endoderm Differentiation Pathway antibodies  Endoderm Differentiation Pathway Diagram
 Mesodermal Commitment Pathway antibodies  Mesodermal Commitment Pathway Diagram
 Metabolic Pathways antibodies  Metabolic Pathways Diagram
 Metabolism Pathway antibodies  Metabolism Pathway Diagram
 Metabolism Of Nucleotides Pathway antibodies  Metabolism Of Nucleotides Pathway Diagram
 Nucleotide Metabolism Pathway antibodies  Nucleotide Metabolism Pathway Diagram
 Purine Metabolism Pathway antibodies  Purine Metabolism Pathway Diagram
 Purine Metabolism Pathway antibodies  Purine Metabolism Pathway Diagram
Diseases associated with HPRT1 recombinant proteinOrgans/Tissues associated with HPRT1 recombinant protein
 Disease Name  Pubmed Publications
 Lesch-Nyhan Syndrome Antibodies  >665 publications with HPRT1 and Lesch-Nyhan Syndrome
 Chromosome Aberrations Antibodies  >403 publications with HPRT1 and Chromosome Aberrations
 Hyperuricemia Antibodies  >172 publications with HPRT1 and Hyperuricemia
 Neoplasms, Experimental Antibodies  >157 publications with HPRT1 and Neoplasms, Experimental
 Cell Transformation, Neoplastic Antibodies  >111 publications with HPRT1 and Cell Transformation, Neoplastic
 Kidney Diseases Antibodies  >108 publications with HPRT1 and Kidney Diseases
 Liver Diseases Antibodies  >74 publications with HPRT1 and Liver Diseases
 Liver Neoplasms Antibodies  >67 publications with HPRT1 and Liver Neoplasms
 Adenocarcinoma Antibodies  >60 publications with HPRT1 and Adenocarcinoma
 Lung Neoplasms Antibodies  >56 publications with HPRT1 and Lung Neoplasms
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >1500 publications with HPRT1 and Blood
 Liver Antibodies  >368 publications with HPRT1 and Liver
 Ovary Antibodies  >296 publications with HPRT1 and Ovary
 Brain Antibodies  >279 publications with HPRT1 and Brain
 Lung Antibodies  >219 publications with HPRT1 and Lung
 Kidney Antibodies  >184 publications with HPRT1 and Kidney
 Skin Antibodies  >161 publications with HPRT1 and Skin
 Bone Antibodies  >147 publications with HPRT1 and Bone
 Spleen Antibodies  >145 publications with HPRT1 and Spleen
 Bone Marrow Antibodies  >129 publications with HPRT1 and Bone Marrow
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