View our list of available Coronavirus (COVID-19, SARS-CoV-2, 2019-nCOV) antibodies, recombinant proteins, ELISA Kits... Options Full Datasheet Printer Friendly Datasheet Prepare for Printing Full Datasheet Printer Friendly Datasheet Prepare for Printing Have Questions? Ask Us! Request A Quote Today! Add To Compare List HRG1 beta active protein Catalog # MBS538048 Unit / Price 0.01 mg / $300 +1 FREE 8GB USB 0.05 mg / $475 +1 FREE 8GB USB 5x0.05 mg / $1,955 +2 FREE 8GB USB Product Name Product Info Accession #s Product Desc Diseases/Tissues/Pathways Applications References Product Name HRG1 beta, Active Protein Full Product Name HRG1 beta protein Product Synonym Names Neuregulin1 protein; HRG beta 1 protein; HRG1 beta; Neu differentiation factor protein; HRG beta-1 protein; HRG beta 1; HRG beta-1; Heregulin 1 protein; NRG1-beta1 protein Product Gene Name HRG1 beta active protein[Similar Products] Research Use Only For Research Use Only. Not for use in diagnostic procedures. TOP Sequence Region of HRG1 protein correspond ing to amino acids SHLVKCAEKE KTFCVNGGEC FMVKDLSNPS RYLCKCPNEF TGDRCQNYVM ASFYKHLGIE FMEAE. Host Human Purity/Purification > 98% pure Form/Format Supplied lyophilized with no additives. Reconstitute in water to a concentration of 0.1 - 1.0 mg/ml. Protein Type Recombinant Biological Significance Neuregulin/Heregulin is a family of structurally related polypeptide growth factors derived from alternatively spliced genes (NRG1, NRG2, NRG3 and NRG4). To date, there are over 14 soluble and transmembrane proteins derived from the NRG1 gene. Proteolytic processing of the extracellular domain of the transmembrane NRG1 isoforms release soluble growth factors. HRG1-beta1 contains an Ig domain and an EGF-like domain that is necessary for direct binding to receptor tyrosine kinases erb3 and erb4. This binding induces erb3 and erb4 heterodimerization with erb2, stimulating intrinsic kinase activity, which leads to tyrosine phosphorylation. Bioactivity The ED50 was determined by the dose-dependent stimulation of the proliferation of human MCF-7 cells is approximately 0.5 ng/ml, corresponding to a specific activity of approximately 2 x 10^6 units/mg. Endotoxin Levels Endotoxin level is less than 0.1 ng per ug (1 EU/ug). Expression System E Coli Preparation and Storage Store at 4 degree C until reconstitution. Following reconstitution aliquot and freeze at -20 degree C for long term storage. Avoid repeated freeze/thaw cycles. Active Protein Note Protein activity can be an ambiguous term. Please refer to the data sheet or inquire with Technical Support to determine the definition of activity for this product. Other Notes Small volumes of HRG1 beta active protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply. TOP Related Product Information for HRG1 beta active protein Purified recombinant Human HRG1 beta protein Product Categories/Family for HRG1 beta active protein Cytokines & Growth Factors Applications Tested/Suitable for HRG1 beta active protein User optimized TOP Precautions All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines. Disclaimer While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information. TOP