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HSP 90 recombinant protein

Scan QR to view Datasheet Catalog #    MBS203032
SDS-Page
Unit / Price
0.1 mg  /  $375 +1 FREE 8GB USB
0.5 mg  /  $925 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

HSP 90, Recombinant Protein

★Popular Item★
 Also Known As   

HSP 90, 1-732aa, Human, His tag, E Coli

 Product Synonym Names    Heat shock protein HSP 90-alpha; HSP 86; Renal carcinoma antigen NY-REN-38; HSPC1; HSPCA; Heat shock protein 90-alpha Renal carcinoma antigen NY REN 38; D6S182; FLJ26984; FLJ31884; Heat shock 90kDa protein 1 alpha; heat shock protein 90kDa alpha (cytosolic); class A member 2; HSP84; HSP86; Hsp89; HSP89A; Hsp90; HSP90A; HSP90AA1; HSP90ALPHA; HSP90N; HSPCAL3; HSPCB; HSPN; LAP2; Lipopolysaccharide associated protein2; LPS associated protein 2; NY REN 38 antigen; hsp90; Heat shock protein HSP 90-alpha
 Product Gene Name   

HSP 90 recombinant protein

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Sequence    MGSSHHHHHH SSGLVPRGSH MPEETQTQDQ PMEEEEVETF AFQAEIAQLM SLIINTFYSN KEIFLRELIS NSSDALDKIR YESLTDPSKL DSGKELHINL IPNKQDRTLT IVDTGIGMTK ADLINNLGTI AKSGTKAFME ALQAGADISM IGQFGVGFYS AYLVAEKVTV ITKHNDDEQY AWESSAGGSF TVRTDTGEPM GRGTKVILHL KEDQTEYLEE RRIKEIVKKH SQFIGYPITL FVEKERDKEV SDDEAEEKED KEEEKEKEEK ESEDKPEIED VGSDEEEEKK DGDKKKKKKI KEKYIDQEEL NKTKPIWTRN PDDITNEEYG EFYKSLTNDW EDHLAVKHFS VEGQLEFRAL LFVPRRAPFD LFENRKKKNN IKLYVRRVFI MDNCEELIPE YLNFIRGVVD SEDLPLNISR EMLQQSKILK VIRKNLVKKC LELFTELAED KENYKKFYEQ FSKNIKLGIH EDSQNRKKLS ELLRYYTSAS GDEMVSLKDY CTRMKENQKH IYYITGETKD QVANSAFVER LRKHGLEVIY MIEPIDEYCV QQLKEFEGKT LVSVTKEGLE LPEDEEEKKK QEEKKTKFEN LCKIMKDILE KKVEKVVVSN RLVTSPCCIV TSTYGWTANM ERIMKAQALR DNSTMGYMAA KKHLEINPDH SIIETLRQKA EADKNDKSVK DLVILLYETA LLSSGFSLED PQTHANRIYR MIKLGLGIDE DDPTADDTSA AVTEEMPPLE GDDDTSRMEE VD
 OMIM    X15183 mRNA
 3D Structure    ModBase 3D Structure for P07900
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 Host    E Coli
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 Purity/Purification    > 90% by SDS-PAGE
 Form/Format    Liquid. 20 mM Tris-HCl, pH 7.4, containing 100 mM NaCl
 Concentration    1 mg/ml (determined by Bradford assay) (lot specific)
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 Antigen Species    Human
 Tag Information    His-tag
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 Preparation and Storage    Can be stored at 4 degree C short term (1-2 weeks).
For long term storage, aliquot and store at -20 degree C or -70 degree C.
Avoid repeated freezing and thawing cycles.
 Other Notes    Small volumes of HSP 90 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for HSP 90 recombinant protein

   HSP 90 is a human heat shock protein. In response to adverse change in their environment, cell from all organisms increase the expression of a class of proteins referred to as heat shock or stress protein. The Hsp90, a highly conserved stress-induced protein, is abundantly expressed in most tissues under nonstress conditions and is required for eukaryotic cell viability. Hsp90 is primarily a cytoplasmic protein and its function remains unknown. It exists in a dimeric form and has been observed to bind to several other cellular proteins such as retro-virus kinases, steroid receptor, heme-regulated protein kinase, actin and tubulin. Recombinant human Hsp90 alpha, fused to His-tag at N-terminus, was cloned into an E. coli expression vector and was purified to apparent homogeneity by using conventional column chromatography techniques.
 Product Categories/Family for HSP 90 recombinant protein    Heat Shock Proteins
 Applications Tested/Suitable for HSP 90 recombinant protein   

SDS-PAGE

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 SDS-Page of HSP 90 recombinant protein    HSP 90 recombinant protein SDS-Page image
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NCBI/Uniprot data below describe general gene information for HSP 90. It may not necessarily be applicable to this product.
 NCBI GI #    154146191
 NCBI GeneID    3320
 NCBI Accession #    NP_005339 [Other Products]
 NCBI GenBank Nucleotide #    NM_005348.3 [Other Products]
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 UniProt Primary Accession #    P07900 [Other Products]
 UniProt Secondary Accession #    Q2PP14; Q5CAQ6; Q5CAQ7; Q9BVQ5; A8K500; B3KPJ9 [Other Products]
 UniProt Related Accession #    P07900 [Other Products]
 Molecular Weight    86.8kDa (752aa), confirmed by MALDI-TOF.
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 NCBI Official Full Name    heat shock protein HSP 90-alpha isoform 2
 NCBI Official Synonym Full Names    heat shock protein 90 alpha family class A member 1
 NCBI Official Symbol    HSP90AA1 [Similar Products]
 NCBI Official Synonym Symbols   
EL52; HSPN; LAP2; HSP86; HSPC1; HSPCA; Hsp89; Hsp90; LAP-2; HSP89A; HSP90A; HSP90N; Hsp103; HSPCAL1; HSPCAL4; HEL-S-65p
[Similar Products]
 NCBI Protein Information    heat shock protein HSP 90-alpha
 UniProt Protein Name    Heat shock protein HSP 90-alpha
 UniProt Synonym Protein Names   
Heat shock 86 kDa; HSP 86; HSP86; Lipopolysaccharide-associated protein 2; LAP-2; LPS-associated protein 2; Renal carcinoma antigen NY-REN-38
 UniProt Gene Name    HSP90AA1 [Similar Products]
 UniProt Synonym Gene Names    HSP90A; HSPC1; HSPCA; HSP 86; HSP86; LAP-2; LPS-associated protein 2 [Similar Products]
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 NCBI Summary for HSP 90    The protein encoded by this gene is an inducible molecular chaperone that functions as a homodimer. The encoded protein aids in the proper folding of specific target proteins by use of an ATPase activity that is modulated by co-chaperones. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2012]
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 UniProt Comments for HSP 90    Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity which is essential for its chaperone activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function (PubMed:11274138, PubMed:15577939, PubMed:15937123, PubMed:27353360). Engages with a range of client protein classes via its interaction with various co-chaperone proteins or complexes, that act as adapters, simultaneously able to interact with the specific client and the central chaperone itself. Recruitment of ATP and co-chaperone followed by client protein forms a functional chaperone. After the completion of the chaperoning process, properly folded client protein and co-chaperone leave HSP90 in an ADP-bound partially open conformation and finally, ADP is released from HSP90 which acquires an open conformation for the next cycle (PubMed:27295069, PubMed:26991466). Apart from its chaperone activity, it also plays a role in the regulation of the transcription machinery. HSP90 and its co-chaperones modulate transcription at least at three different levels. In the first place, they alter the steady-state levels of certain transcription factors in response to various physiological cues. Second, they modulate the activity of certain epigenetic modifiers, such as histone deacetylases or DNA methyl transferases, and thereby respond to the change in the environment. Third, they participate in the eviction of histones from the promoter region of certain genes and thereby turn on gene expression (PubMed:25973397). Binds bacterial lipopolysaccharide (LPS) and mediates LPS-induced inflammatory response, including TNF secretion by monocytes (PubMed:11276205). Antagonizes STUB1-mediated inhibition of TGF-beta signaling via inhibition of STUB1-mediated SMAD3 ubiquitination and degradation (PubMed:24613385).
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Product References and Citations for HSP 90 recombinant protein

   Lai, B-T., et al. (1984) Molecular & Cellular Biol. 4: 2802-2810.; Pritchard, K. A., et al. (2001) J. Biol. Chem. 276:17621-17624; Miyamoto, A., et al. (2002) Nature 416:865-869;
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 Research Articles on HSP 90    1. Results identified GRP78 and HSP90a as binding partners of PRDM14 in triple-negative breast cancer cells, and all participate in cancer regulation. The interactions were direct and required the C-terminal region including the zinc finger motifs of PRDM14.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with HSP 90 recombinant proteinPathways associated with HSP 90 recombinant protein
 Reference Product  PubMed Publications
 PTGES3 recombinant protein  >4 publications with HSP 90 and PTGES3
 STIP1 recombinant protein  >3 publications with HSP 90 and STIP1
 HSPA4 recombinant protein  >2 publications with HSP 90 and HSPA4
 CDC37 recombinant protein  >2 publications with HSP 90 and CDC37
 Products by Pathway  Pathway Diagram
 AURKA Activation By TPX2 Pathway antibodies  AURKA Activation By TPX2 Pathway Diagram
 Anchoring Of The Basal Body To The Plasma Membrane Pathway antibodies  Anchoring Of The Basal Body To The Plasma Membrane Pathway Diagram
 Antigen Processing And Presentation Pathway antibodies  Antigen Processing And Presentation Pathway Diagram
 Antigen Processing And Presentation Pathway antibodies  Antigen Processing And Presentation Pathway Diagram
 Aryl Hydrocarbon Receptor Pathway antibodies  Aryl Hydrocarbon Receptor Pathway Diagram
 Aryl Hydrocarbon Receptor Pathway antibodies  Aryl Hydrocarbon Receptor Pathway Diagram
 Attenuation Phase Pathway antibodies  Attenuation Phase Pathway Diagram
 Axon Guidance Pathway antibodies  Axon Guidance Pathway Diagram
 Binding And Uptake Of Ligands By Scavenger Receptors Pathway antibodies  Binding And Uptake Of Ligands By Scavenger Receptors Pathway Diagram
 Cell Cycle Pathway antibodies  Cell Cycle Pathway Diagram
Diseases associated with HSP 90 recombinant proteinOrgans/Tissues associated with HSP 90 recombinant protein
 Disease Name  Pubmed Publications
 Nervous System Diseases Antibodies  >12 publications with HSP 90 and Nervous System Diseases
 Liver Diseases Antibodies  >8 publications with HSP 90 and Liver Diseases
 Inflammation Antibodies  >8 publications with HSP 90 and Inflammation
 Cardiovascular Diseases Antibodies  >8 publications with HSP 90 and Cardiovascular Diseases
 Disease Models, Animal Antibodies  >6 publications with HSP 90 and Disease Models, Animal
 Carcinoma, Hepatocellular Antibodies  >5 publications with HSP 90 and Carcinoma, Hepatocellular
 Necrosis Antibodies  >5 publications with HSP 90 and Necrosis
 Liver Neoplasms Antibodies  >5 publications with HSP 90 and Liver Neoplasms
 Lung Neoplasms Antibodies  >4 publications with HSP 90 and Lung Neoplasms
 Breast Neoplasms Antibodies  >4 publications with HSP 90 and Breast Neoplasms
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >16 publications with HSP 90 and Blood
 Brain Antibodies  >11 publications with HSP 90 and Brain
 Liver Antibodies  >10 publications with HSP 90 and Liver
 Lung Antibodies  >10 publications with HSP 90 and Lung
 Muscle Antibodies  >10 publications with HSP 90 and Muscle
 Testis Antibodies  >7 publications with HSP 90 and Testis
 Vascular Antibodies  >5 publications with HSP 90 and Vascular
 Heart Antibodies  >5 publications with HSP 90 and Heart
 Embryonic Tissue Antibodies  >4 publications with HSP 90 and Embryonic Tissue
 Bone Antibodies  >4 publications with HSP 90 and Bone
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